Effects of nicotinic and muscarinic compounds on biting attack in the cat
Abstract
Predatory-like biting attack on a rat, as well as hissing, growling, and other threat behaviors, could be induced in normally non-aggressive cats by systemic administration of the muscarinic agonist, arecoline (7-12 mg/kg). In contrast to arecoline, nicotine was found to suppress aggressive behaviors. Systemic administration of nicotine (0.5 mg/kg) prior to arecoline injection resulted in a significant reduction in elicited attack and threat behaviors. Furthermore, nicotine (0.075-0.500 mg/kg) was found to produce a dose-dependent suppression of natural predatory behavior as well. This nicotine-produced suppression of attack did not appear to be due to the induction of general malaise, since attack suppression could be seen in the absence of general behavioral inhibition, and doses of nicotine resulting in complete suppression of attack had little effect on food intake. Results indicate that muscarinic and nicotinic compounds can exert antagonistic control over some types of aggressive behaviors.
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Cats specifically reduced biting, an aggressive behavior, while pawing and cuffing, non-aggressive behaviors, remained stable or increased.
“Cats specifically reduced biting, an aggressive behavior, while pawing and cuffing, non-aggressive behaviors, remained stable or increased, supporting the idea that nicotine had specific effects on behaviors related to aggression.”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Berntson et al., 1976
In cats, nicotine reduced aggression in a dose-dependent manner in a rat-biting assay, and doses highly effective at reducing aggression did not cause changes in food intake.
“In cats, nicotine reduced aggression in a dose-dependent manner in a rat-biting assay, and doses that were highly effective at reducing aggression did not cause changes in food intake, suggesting a specific effect on aggression (Berntson et al., 1976).”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Berntson et al., 1976
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- Authors
- Berntson, G. G., Beattie, M. S., & Michael Walker, J.
- Affiliations
- The Ohio State University (US)
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1976-09
- Volume
- 5
- Issue
- 3
- Pages
- 235-239
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2043420340
- Cited by
- 36
- References
- 31
- Citations by year
- 2022: 1 · 2021: 2 · 2019: 1 · 2015: 3
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine, arecoline, muscarinic agonists, nicotinic agonists, predatory behavior, threatening behavior, aggression, cats, rats
- MeSH terms
- Aggression, Animals, Arecoline, Atropine, Cats, Female, Hexamethonium Compounds, Humans, Male, Nicotine, Time Factors
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