Psychomotor stimulants, social deprivation and play in juvenile rats
Abstract
Treatment with d-amphetamine (0.125-1 mg/Kg) or methylphenidate (0.5-4 mg/kg caused dose-dependent decreases in play fighting in juvenile rats which were independent of sex and strain. Although brief social isolation profoundly increased play fighting, qualitatively similar drug effects on play were observed in socially housed and isolated animals. By contrast, at the highest doses tested both amphetamine and methylphenidate increased social investigation, but only if the rats were socially isolated. Stimulation of catecholamine systems is evidently incompatible with the expression of playful behavior.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The specific reduction in social play after methylphenidate treatment is consistent with previous findings.
“This specific reduction in social play after methylphenidate treatment is consistent with previous findings (Beatty et al. 1982; Vanderschuren et al. 2008)”
From Neurexin1α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia (2025) · cites this paper as Beatty et al. 1982
Cited by
Sorted by citations
The psychobiology of play: Theoretical and methodological perspectives
Panksepp, J., Siviy, S., & Normansell, L. (1984) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(84)90005-8 · Cited by 468 · see citing works
The pleasures of play: pharmacological insights into social reward mechanisms
Trezza, V., Baarendse, P. J. J., & Vanderschuren, L. J. M. J. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.06.008 · Cited by 372 · see citing works
The neurobiology of social play and its rewarding value in rats
Vanderschuren, L. J. M. J., Achterberg, E. J. M., & Trezza, V. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.025 · Cited by 329 · see citing works
Social Behavior and Social Motivation in Adolescent Rats
Varlinskaya, E. I., Spear, L. P., & Spear, N. E. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00285-6 · Cited by 194 · see citing works
Varlinskaya, E. I., & Spear, L. P. (2004) · Alcoholism: Clinical and Experimental Research · doi:10.1097/01.alc.0000108655.51087.df · Cited by 176 · see citing works
Thiel, K. J., Okun, A. C., & Neisewander, J. L. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.02.013 · Cited by 164 · see citing works
Peña, C. J., Neugut, Y. D., Calarco, C. A., & Champagne, F. A. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12479 · Cited by 120 · see citing works
Early exposure to a low dose of bisphenol A affects socio-sexual behavior of juvenile female rats
Porrini, S., Belloni, V., Seta, D. D., Farabollini, F., Giannelli, G., & Dessì-Fulgheri, F. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.11.014 · Cited by 114 · see citing works
Ku, K. M., Weir, R. K., Silverman, J. L., Berman, R. F., & Bauman, M. D. (2016) · PLOS ONE · doi:10.1371/journal.pone.0158150 · Cited by 74 · see citing works
Achterberg, E. J. M., van Kerkhof, L. W. M., Damsteegt, R., Trezza, V., & Vanderschuren, L. J. M. J. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2945-14.2015 · Cited by 58 · see citing works
The neurobiology of social play behaviour: Past, present and future
Achterberg, E. J. M., & Vanderschuren, L. J. M. J. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105319 · Cited by 56 · see citing works
Argue, K. J., VanRyzin, J. W., Falvo, D. J., Whitaker, A. R., Yu, S. J., & McCarthy, M. M. (2017) · eneuro · doi:10.1523/eneuro.0344-16.2017 · Cited by 47 · see citing works
Opioid addiction: who are your real friends?
Eitan, S., Emery, M. A., Bates, M. L. S., & Horrax, C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.017 · Cited by 42 · see citing works
Neurexin1α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia
Achterberg, E. J. M., Biemans, B., & Vanderschuren, L. J. M. J. (2025) · Psychopharmacology · doi:10.1007/s00213-024-06559-z · Cited by 9 · see citing works
“This specific reduction in social play after methylphenidate treatment is consistent with previous findings (Beatty et al. 1982; Vanderschuren et al. 2008), and we have demonstrated that methylphenidate inhibits social play behaviour through indirect stimulation of alpha-2 adrenoceptors…”
- Authors
- Beatty, W. W., Dodge, A. M., Dodge, L. J., White, K., & Panksepp, A.
- Affiliations
- North Dakota State University (US)
- Bowling Green State University (US)
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1982-03
- Volume
- 16
- Issue
- 3
- Pages
- 417-422
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2040321695
- Cited by
- 126
- References
- 0
- Citations by year
- 2024: 5 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 1
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- psychostimulants, amphetamine, methylphenidate, play fighting, social isolation, social deprivation, young rats, social investigation, catecholaminergic system, play behavior
- MeSH terms
- Aggression, Central Nervous System Stimulants, Animals, Dextroamphetamine, Dose-Response Relationship, Drug, Humans, Male, Methylphenidate, Play and Playthings, Social Behavior, Social Isolation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
