The effect of 6-OHDA lesions of the nucleus accumbens septum on schedule-induced drinking, wheelrunning and corticosterone levels in the rat

Wallace, M.; Singer, G.; Finlay, J.; Gibson, S.

doi:10.1016/0091-3057(83)90262-9

Cited by 96Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolRegulation of Appetite and Obesity

The effect of 6-OHDA lesions of the nucleus accumbens septum on schedule-induced drinking, wheelrunning and corticosterone levels in the rat

Wallace, M., Singer, G., Finlay, J., Gibson, S.·1983·Pharmacology Biochemistry and Behavior

DOI 10.1016/0091-3057(83)90262-9

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Abstract

In a series of four experiments the relationship between 6-OHDA lesions of the nucleus accumbens septum (NAS), schedule-induced behaviors and plasma corticosterone levels was explored. Data from the first experiment show a significant decrease in water intake during a scheduled food delivery test hour for 6-OHDA lesioned groups of rats compared with sham or non-lesioned groups of rats, while during the remaining 23 hours of the day water intake was the same for 6-OHDA lesioned and sham lesioned groups. In a second experiment similar decreases in schedule-induced wheelrunning were observed for 6-OHDA lesioned rats when compared with sham lesioned rats. Data from a third experiment showed significant increases in plasma corticosterone levels of rats in the presence of a scheduled food delivery compared with rats given non-scheduled food. In a fourth experiment it was shown that 6-OHDA lesions of the NAS abolish this increase of corticosterone levels in rats on a food delivery schedule. These data extend the findings of Robbins and Koob [19] and show a more general involvement of the dopaminergic pathways of the NAS in schedule-induced behaviors and in concomitant plasma corticosterone changes.

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Lesions of the meso-limbic dopamine system by 6-OHDA disrupt adjunctive behaviors induced by intermittent delivery of food to hungry rats, including heightened water consumption, wheel-running and plasma glucocorticoid.
“Lesions of the meso-limbic dopamine system by 6-OHDA disrupt adjunctive behaviors induced by intermittent delivery of food to hungry rats, including heightened water consumption (schedule induced-polydipsia), wheel-running and plasma glucocorticoid (Robbins and Koob, 1980; Wallace et al., 1983).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Wallace et al., 1983

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Authors: Wallace, M., Singer, G., Finlay, J., & Gibson, S.
Affiliations: La Trobe University (AU)
ORCID: Singer, G.
Gibson, S.
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 1983-01
Volume: 18
Issue: 1
Pages: 129-136
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/0091-3057(83)90262-9
OpenAlex: W2030874025
Cited by: 96
References: 31
Citations by year: 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 2
FWCI: 1.86
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: 6-hydroxydopamine lesion, schedule-induced drinking, plasma corticosterone, dopaminergic pathways, water intake
MeSH terms: Animals, Corticosterone, Drinking Behavior, Hydroxydopamines, Male, Motor Activity, Nucleus Accumbens, Septal Nuclei, Time Factors, Rats

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The effect of 6-OHDA lesions of the nucleus accumbens septum on schedule-induced drinking, wheelrunning and corticosterone levels in the rat

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