The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Mitochondrial protein import: Identification of processing peptidase and of PEP, a processing enhancing protein
Open accessAbstract
Transport of nuclear-encoded precursor proteins into mitochondria includes proteolytic cleavage of amino-terminal targeting sequences in the mitochondrial matrix. We have isolated the processing activity from Neurospora crassa. The final preparation (enriched ca. 10,000-fold over cell extracts) consists of two proteins, the matrix processing peptidase (MPP, 57 kd) and a processing enhancing protein (PEP, 52 kd). The two components were isolated as monomers. PEP is about 15-fold more abundant in mitochondria than MPP. It is partly associated with the inner membrane, while MPP is soluble in the matrix. MPP alone has a low processing activity whereas PEP alone has no apparent activity. Upon recombining both, full processing activity is restored. Our data indicate that MPP contains the catalytic site and that PEP has an enhancing function. The mitochondrial processing enzyme appears to represent a new type of "signal peptidase," different from the bacterial leader peptidase and the signal peptidase of the endoplasmic reticulum.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Burnette, W. N. (1981) · Analytical Biochemistry · doi:10.1016/0003-2697(81)90281-5 · Cited by 8,429
Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing
Henikoff, S. (1984) · Gene · doi:10.1016/0378-1119(84)90153-7 · Cited by 4,145
An Efficient mRNA‐Dependent Translation System from Reticulocyte Lysates
PELHAM, H. R. B., & JACKSON, R. J. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb10656.x · Cited by 3,926
Assay of proteins in the presence of interfering materials
Bensadoun, A., & Weinstein, D. (1976) · Analytical Biochemistry · doi:10.1016/s0003-2697(76)80064-4 · Cited by 3,179
Empirical Predictions of Protein Conformation
Chou, P. Y., & Fasman, G. D. (1978) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.47.070178.001343 · Cited by 3,124
Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA
CHEN, E. Y., & SEEBURG, P. H. (1985) · DNA · doi:10.1089/dna.1985.4.165 · Cited by 2,436
Fujiki, Y., Hubbard, A. L., Fowler, S., & Lazarow, P. B. (1982) · The Journal of cell biology · doi:10.1083/jcb.93.1.97 · Cited by 1,751
Current Topics in Bioenergetics
(1991) · Elsevier eBooks · doi:10.1016/b978-0-12-152516-3.x5001-3 · Cited by 1,185
Cited by
Predicting Subcellular Localization of Proteins Based on their N-terminal Amino Acid Sequence
Emanuelsson, O., Nielsen, H., Brunak, S., & von Heijne, G. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3903 · Cited by 4,263
Mitochondrial Machineries for Protein Import and Assembly
Wiedemann, N., & Pfanner, N. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014352 · Cited by 890
The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains
Walker, J. E. (1992) · Quarterly Reviews of Biophysics · doi:10.1017/s003358350000425x · Cited by 781
Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis
Ostermann, J., Horwich, A. L., Neupert, W., & Hartl, F.-U. (1989) · Nature · doi:10.1038/341125a0 · Cited by 677
Self-citationEmerging mechanisms for heavy metal transport in plants
Williams, L. E., Pittman, J. K., & Hall, J. L. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00133-4 · Cited by 629
Metadata
- Authors
- Hawlitschek, G., Schneider, H., Schmidt, B., Tropschug, M., Hartl, F.-U., & Neupert, W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1988-06
- Volume
- 53
- Issue
- 5
- Pages
- 795-806
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2067310224
- Cited by
- 395
- References
- 47
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mitochondrial protein import: Identification of processing peptidase and of PEP, a processing enhancing protein. https://app.cochat.ai/papers/10.1016/0092-8674(88)90096-7
- The paper
- Hawlitschek, G., Schneider, H., Schmidt, B., Tropschug, M., Hartl, F.-U., & Neupert, W. (1988). Mitochondrial protein import: Identification of processing peptidase and of PEP, a processing enhancing protein. Cell. https://doi.org/10.1016/0092-8674(88)90096-7
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
