The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Mitochondrial Machineries for Protein Import and Assembly
Open accessAbstract
Mitochondria are essential organelles with numerous functions in cellular metabolism and homeostasis. Most of the >1,000 different mitochondrial proteins are synthesized as precursors in the cytosol and are imported into mitochondria by five transport pathways. The protein import machineries of the mitochondrial membranes and aqueous compartments reveal a remarkable variability of mechanisms for protein recognition, translocation, and sorting. The protein translocases do not operate as separate entities but are connected to each other and to machineries with functions in energetics, membrane organization, and quality control. Here, we discuss the versatility and dynamic organization of the mitochondrial protein import machineries. Elucidating the molecular mechanisms of mitochondrial protein translocation is crucial for understanding the integration of protein translocases into a large network that controls organelle biogenesis, function, and dynamics.
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Cites
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Cited by
Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: Recent advances.
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Mitochondrial proteins: from biogenesis to functional networks
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Self-citationMaintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging
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Metadata
- Authors
- Wiedemann, N., & Pfanner, N.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2017-06-20
- Volume
- 86
- Issue
- 1
- Pages
- 685-714
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2552202209
- Cited by
- 890
- References
- 9
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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