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Cited by 890

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Mitochondrial Machineries for Protein Import and Assembly

Open access
Wiedemann, Nils, Pfanner, Nikolaus·2017·Annual Review of Biochemistry

Abstract

Mitochondria are essential organelles with numerous functions in cellular metabolism and homeostasis. Most of the >1,000 different mitochondrial proteins are synthesized as precursors in the cytosol and are imported into mitochondria by five transport pathways. The protein import machineries of the mitochondrial membranes and aqueous compartments reveal a remarkable variability of mechanisms for protein recognition, translocation, and sorting. The protein translocases do not operate as separate entities but are connected to each other and to machineries with functions in energetics, membrane organization, and quality control. Here, we discuss the versatility and dynamic organization of the mitochondrial protein import machineries. Elucidating the molecular mechanisms of mitochondrial protein translocation is crucial for understanding the integration of protein translocases into a large network that controls organelle biogenesis, function, and dynamics.

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Crossref · 10.1146/annurev-biochem-060815-014352

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Metadata

Authors
Wiedemann, N., & Pfanner, N.
Venue
Annual Review of Biochemistry
Published
2017-06-20
Volume
86
Issue
1
Pages
685-714
ISSN
  • 0066-4154 (ISSN-L)
  • 1545-4509
OpenAlex
W2552202209
Cited by
890
References
9
FWCI
5.99
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Mitochondrial Machineries for Protein Import and Assembly. https://app.cochat.ai/papers/10.1146/annurev-biochem-060815-014352
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Wiedemann, N., & Pfanner, N. (2017). Mitochondrial Machineries for Protein Import and Assembly. Annual Review of Biochemistry. https://doi.org/10.1146/annurev-biochem-060815-014352

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.