The p53 proto-oncogene can act as a suppressor of transformation

A new technique for the assay of infectivity of human adenovirus 5 DNA

Graham, F. L., & van der Eb, A. J. (1973) · Virology · doi:10.1016/0042-6822(73)90341-3 · Cited by 9,302

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

Southern, P. J., & Berg, P. R. (1982) · PubMed · Cited by 2,740

T antigen is bound to a host protein in SY40-transformed cells

Lane, D. P., & Crawford, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,456

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

Linzer, D. I. H., & Levine, A. J. (1979) · Cell · doi:10.1016/0092-8674(79)90293-9 · Cited by 1,814

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

DeCaprio, J. A., Ludlow, J. W., Figge, J., Shew, J.-Y., Huang, C.-M., Lee, W.-H., Marsilio, E., Paucha, E., & Livingston, D. M. (1988) · Cell · doi:10.1016/0092-8674(88)90559-4 · Cited by 1,459

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

Lee, W., Bookstein, R., Hong, F., Young, L.-J., Shew, J., & Lee, E. Y.-H. P. (1987) · Science · doi:10.1126/science.3823889 · Cited by 1,417

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

Whyte, P., Buchkovich, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A., & Harlow, E. (1988) · Nature · doi:10.1038/334124a0 · Cited by 1,403

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

Ruley, H. E. (1983) · Nature · doi:10.1038/304602a0 · Cited by 1,248

Targeting Therapies for the p53 Protein in Cancer Treatments

Levine, A. J. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055455 · Cited by 84

Versatile functions of p53 protein in multicellular organisms

Chumakov, P. M. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907130019 · Cited by 85

Undifferentiated spindle cell carcinoma of the gallbladder: A clinicopathologic, immunohistochemical, and flow cytometric study of 11 cases

Nishihara, K., & Tsuneyoshi, M. (1993) · Human Pathology · doi:10.1016/0046-8177(93)90263-g · Cited by 84

Expression of the tumour suppressor gene p53 in oral cancer

Langdon, J., & Partridge, M. (1992) · British Journal of Oral and Maxillofacial Surgery · doi:10.1016/0266-4356(92)90263-i · Cited by 84

Cancer risks from germline p53 mutations.

Frébourg, T., & Friend, S. H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116034 · Cited by 82

p53 and retinoblastoma pathways in bladder cancer

Mitra, A. P., Birkhahn, M., & Côté, R. J. (2007) · World Journal of Urology · doi:10.1007/s00345-007-0197-0 · Cited by 84

Expression of the retinoblastoma-related gene Rb2/p130 correlates with clinical outcome in endometrial cancer.

Susini, T., Baldi, F., Howard, C. M., Baldi, A., Taddei, G. L., Massi, D., Rapi, S., Savino, L., Massi, G., & Giordano, A. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.3.1085 · Cited by 83

Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments

de Fromentel, C. C., Gruel, N., Venot, C., Debüssche, L., Conseiller, E., Dureuil, C., Teillaud, J., Tocqué, B., & Bracco, L. P. (1999) · Oncogene · doi:10.1038/sj.onc.1202338 · Cited by 83

p53 expression in colorectal adenomas.

Kaklamanis, L., Gatter, K. C., Mortensen, N. J. M. C., Baigrie, R. J., Heryet, A. R., Lane, D. P., & Harris, A. L. (1993) · PubMed Central · Cited by 83

Targeting Tumor Suppressor Networks for Cancer Therapeutics

Guo, X. E., Ngo, B., Modrek, A. S., & Lee, W. (2014) · Current Drug Targets · doi:10.2174/1389450114666140106095151 · Cited by 89

Deregulation and Targeting of TP53 Pathway in Multiple Myeloma

Jovanović, K., Escure, G., Demonchy, J., Willaume, A., de Wyngaert, Z. V., Farhat, M.-M., Chauvet, P., Facon, T. T. F., Quesnel, B., & Manier, S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2018.00665 · Cited by 86

Correlation of Ki-67 and p53 With the New World Health Organization/International Society of Urological Pathology Classification System for Urothelial Neoplasia

Cina, S. J., Lancaster‐Weiss, K., Lecksell, K., & Epstein, J. I. (2001) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2001-125-0646-cokapw · Cited by 82

Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapse phase

Hsiao, M., Yu, A. L.-T., Yeargin, J., Ku, D., & Haas, M. (1994) · Blood · doi:10.1182/blood.v83.10.2922.2922 · Cited by 82

The ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40

Lin, J., & Simmons, D. T. (1991) · Journal of Virology · doi:10.1128/jvi.65.12.6447-6453.1991 · Cited by 82

Apoptosis and gastrointestinal pharmacology

Pritchard, D. M., & Watson, A. J. M. (1996) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00102-7 · Cited by 82

Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts

Schuster, R., Gerlich, W. H., & Schaefer, S. (2000) · Oncogene · doi:10.1038/sj.onc.1203417 · Cited by 86

Expression of P53 protein in normal, dysplastic, and malignant gastric mucosa: An immunohistochemical study

Joypaul, B. V., Newman, E. L., Hopwood, D., Grant, A., Qureshi, S. S., Lane, D. P., & Cuschieri, A. (1993) · The Journal of Pathology · doi:10.1002/path.1711700310 · Cited by 82

Regulation of Metabolic Activity by p53

Flöter, J., Kaymak, I., & Schulze, A. (2017) · Metabolites · doi:10.3390/metabo7020021 · Cited by 81

The p53 gene in pediatric therapy-related leukemia and myelodysplasia

Felix, C., Hosler, M. R., Provisor, D., Salhany, K., Sexsmith, E., Slater, D., Cheung, N., Winick, N., Strauss, E., Heyn, R. M., et al. (1996) · Blood · doi:10.1182/blood.v87.10.4376.bloodjournal87104376 · Cited by 79

p53--An Acrobat in Tumorigenesis

Moll, U. M., & Schramm, L. (1998) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411980090010101 · Cited by 81

Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines.

Caamaño, J., Ruggeri, B., Momiki, S., Sickler, A., Zhang, S. Y., & Klein–Szanto, A. J. (1991) · PubMed Central · Cited by 81

Hepatitis B injury, male gender, aflatoxin, and p53 expression each contribute to hepatocarcinogenesis in transgenic mice†

Ghebranious, N., & Sell, S. (1998) · Hepatology · doi:10.1002/hep.510270211 · Cited by 81

p21 Ras as a governor of global gene expression.

Abdellatif, M., MacLellan, W. R., & Schneider, M. D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40695-8 · Cited by 81

c-Myc oncoprotein function

Dang, C. V. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(91)90009-a · Cited by 78

Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci.

Chen, T.-H. T., Brody, J. R., Romantsev, F. E., Yu, J., Kayler, A. E., Voneiff, E., Kuhajda, F. P., & Pasternack, G. R. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.12.2045 · Cited by 80

p53 Oncoprotein Expression and Proliferation Index in Keratoacanthoma and Squamous Cell Carcinoma

KERSCHMANN, R. L. (1994) · Archives of Dermatology · doi:10.1001/archderm.130.2.181 · Cited by 80

Nitrite/ nitrate and cytokine levels in bronchoalvelar lavage fluid of lung cancer patients

Arias‐Díaz, J., Vara, E., Torres-Melero, J., Garcı́a, C., Baki, W., Ramσrez-Armengol, J. A., & Balibrea, J. L. (1994) · Cancer · doi:10.1002/1097-0142(19940901)74:5 · Cited by 73

TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions

Shirole, N. H., Pal, D., Kastenhuber, E. R., Şentürk, Ş., Boroda, J. U., Pisterzi, P., Miller, M., Munoz, G., Anderluh, M., Ladanyi, M., et al. (2016) · eLife · doi:10.7554/elife.17929 · Cited by 80

Anticancer peptides mechanisms, simple and complex

Norouzi, P., Mirmohammadi, M., & Tehrani, M. H. H. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110194 · Cited by 80

Human Tumor Antigens Are Ready to Fly

Henderson, R. A., & Finn, O. J. (1996) · Advances in immunology · doi:10.1016/s0065-2776(08)60431-9 · Cited by 78

Significance of p53 expression as a prognostic factor in oesophageal squamous cell carcinoma

Shimaya, K., Shiozaki, H., Inoue, M., Tahara, H., Monden, T., Shimano, T., & Mori, T. (1993) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01608335 · Cited by 79

The Paradox of p53: What, How, and Why?Preprint

Aylon, Y., & Oren, M. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026328 · Cited by 81

The clinical significance of antigen receptor gene rearrangements in lymphoid neoplasia

Sklar, J., & Longtine, J. (1992) · Cancer · doi:10.1002/1097-0142(19920915)70:4+ · Cited by 22

Prognosis, Biology, and Targeting of TP53 Dysregulation in Multiple Myeloma

Flynt, E., Bisht, K. K., Sridharan, V., Ortiz, M., Towfic, F., & Thakurta, A. (2020) · Cells · doi:10.3390/cells9020287 · Cited by 79

AEBP1 is a Novel Oncogene: Mechanisms of Action and Signaling Pathways

Majdalawieh, A. F., Massri, M., & Ro, H.-S. (2020) · Journal of Oncology · doi:10.1155/2020/8097872 · Cited by 78

Giant cell tumor of bone: A clinicopathologic study of prognostic factors

Masui, F., Ushigome, S., & Fujii, K. (1998) · Pathology International · doi:10.1111/j.1440-1827.1998.tb03973.x · Cited by 78

Epidemiology, etiology, and fertility drugs in ovarian epithelial carcinoma: Where are we today?

Wallach, E. E., & Shoham, Z. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56928-3 · Cited by 78

p53 Gene mutations in gastric and esophageal cancers

Imazeki, F., Omata, M., Nose, H., Ohto, M., & Isono, K. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90022-q · Cited by 78

p53 is associated with p34cdc2 in transformed cells.

Milner, J., Cook, A., & Mason, J. M. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07478.x · Cited by 78

Altered-Function p53 Missense Mutations Identified in Breast Cancers Can Have Subtle Effects on Transactivation

Jordan, J. J., Inga, A., Conway, K., Edmiston, S. N., Carey, L., Wu, L., & Resnick, M. A. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0442 · Cited by 77

Decreased expression of DCC mRNA in human colorectal cancers

Itoh, F., Hinoda, Y., Ohe, M., Ohe, Y., Ban, T., Endo, T., Imai, K., & Yachi, A. (1993) · International Journal of Cancer · doi:10.1002/ijc.2910530215 · Cited by 77

Rat p53 gene mutations in primary Zymbal gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen.

Makino, H., Ishizaka, Y., Tsujimoto, A., Nakamura, T., Onda, M., Sugimura, T., & Nagao, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.4850 · Cited by 76

Cytotoxicity and Genotoxicity of Carbon Nanomaterials

Schrand, A. M., Johnson, J. F., Dai, L., Hussain, S. M., Schlager, J. J., Zhu, L. H., Hong, Y., & O̅sawa, E. (2008) · Nanostructure science and technology · doi:10.1007/978-0-387-78608-7_8 · Cited by 76

What have animal models taught us about the p53 pathway?

Lozano, G., & Zambetti, G. P. (2005) · The Journal of Pathology · doi:10.1002/path.1704 · Cited by 78

p53 expression during normal tissue regeneration in response to acute cutaneous injury in swine.

Antoniades, H. N., Galanopoulos, T., Neville-Golden, J., Kiritsy, C. P., & Lynch, S. E. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117217 · Cited by 76

The effectiveness of a mixture of β‐carotene, α‐tocopherol, glutathione, and ascorbic acid for cancer prevention

Shklar, G., Schwartz, J., Trickier, D., & Reid, S. (1993) · Nutrition and Cancer · doi:10.1080/01635589309514281 · Cited by 76

Overview of the Biologic Markers of Breast Cancer

Porter-Jordan, K., & Lippman, M. E. (1994) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30188-6 · Cited by 76

Infiltrating lobular carcinoma of the breast: Clinicopathologic analysis of 975 cases with reference to data on conservative therapy and metastatic patterns

Sastre‐Garau, X., Jouve, M., Asselain, B. J. R., Vincent‐Salomon, A., Beuzeboc, P., Dorval, T., Durand, J. C., Fourquet, A., & Pouillart, P. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960101)77:1 · Cited by 422

Ameloblastic carcinoma ex ameloblastoma: report of a case–possible involvement of CpG island hypermethylation of the p16 gene in malignant transformation

Abiko, Y., Nagayasu, H., Takeshima, M., Yamazaki, M., Nishimura, M., Kusano, K., Kitajo, H., Saitoh, M., Kawakami, T., Chiba, I., et al. (2006) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2006.01.021 · Cited by 75

30 years and a long way into p53 research

Hainaut, P. L., & Wiman, K. G. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70198-6 · Cited by 80

Body mass and breast cancer: Relationship between method of detection and stage of disease

Reeves, M. J., Newcomb, P. A., Remington, P., Marcus, P. M., & Kenzie, W. R. M. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960115)77:2 · Cited by 73

p53 mutations in all stages of thyroid carcinomas

Zou, M., Shi, Y., & Farid, N. R. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.4.1054 · Cited by 75

Human p53 inhibits growth in Schizosaccharomyces pombe.

Bischoff, J. R., Casso, D. J., & Beach, D. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.4.1405 · Cited by 75

Deletion of 17p and amplification of the int-2 gene in esophageal carcinomas.

Wagata, T., Ishizaki, K., Imamura, M., Shimada, Y., Ikenaga, M., & Tobe, T. (1991) · PubMed · Cited by 75

Unique p53 and epidermal growth factor receptor gene mutation status in 46 pulmonary lymphoepithelioma‐like carcinomas

Chang, Y., Wu, C., Shih, J., & Lee, Y.-C. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01768.x · Cited by 74

Hepatitis B virus infection and primary hepatocellular carcinoma

Feitelson, M. A. (1992) · Clinical Microbiology Reviews · doi:10.1128/cmr.5.3.275 · Cited by 74

The p53 Stabilizing Compound CP-31398 Induces Apoptosis by Activating the Intrinsic Bax/Mitochondrial/Caspase-9 Pathway

Luu, Y., Bush, J., Cheung, K. J., & Li, G. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5526 · Cited by 74

Mutations in p53 do not account for heritable breast cancer: a study in five affected families

Prosser, J., Elder, P. A., Condie, A., MacFadyen, I., Steel, C. M., & Evans, H. J. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.44 · Cited by 74

p53 mutations do not predict response to paclitaxel/radiation for nonsmall cell lung carcinoma

Safran, H. P., King, T. C., Choy, H., Gollerkeri, A. M., Kwakwa, H. A., Lopez, F., Cole, B. F., Myers, J., Tarpey, J. T., & Rosmarin, A. G. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960915)78:6 · Cited by 68

Cellular and Molecular Pathology of Prostate Cancer Precursors

Foster, C. S., Bostwick, D. G., Bonkhoff, H., Damber, J., van der Kwast, T., Montironi, R., & Sakr, W. A. (2000) · Scandinavian Journal of Urology and Nephrology · doi:10.1080/003655900750169284 · Cited by 74

Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter

Ressler, S. J., Morris, G. F., & Marriott, S. J. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.1181-1190.1997 · Cited by 74

Immunohistochemical and molecular analysis of p53, RB, and PTEN in malignant peripheral nerve sheath tumors

Mawrin, C., Kirches, E., Boltze, C., Dietzmann, K., Roessner, A., & Schneider‐Stock, R. (2001) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-001-0550-4 · Cited by 73

Loss of heterozygosity and mutation analysis of the p16 (9p21) and p53 (17p13) genes in squamous cell carcinoma of the head and neck.

González, M. V., Pello, M. F., López‐Larrea, C., Suarez, C. M., Menéndez, M., & Coto, E. (1995) · PubMed · Cited by 73

Search for accumulation of p53 protein and detection of human papillomavirus genomes in sebaceous gland carcinoma of the eyelid

Hayashi, N., Ueno, H., Furihata, M., & OHTSUKI, Y. (1994) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00191436 · Cited by 73

p53 Mutants Have Selective Dominant-Negative Effects on Apoptosis but Not Growth Arrest in Human Cancer Cell Lines

Aurelio, O. N., Kong, X., Gupta, S., & Stanbridge, E. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.770-778.2000 · Cited by 75

The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells

Quartin, R. S., Cole, C. N., Pipas, J. M., & Levine, A. J. (1994) · Journal of Virology · doi:10.1128/jvi.68.3.1334-1341.1994 · Cited by 73

Temperature-dependent switching between “wild-type” and “mutant” forms of p53-Val135

Milner, J., & Medcalf, E. (1990) · Journal of Molecular Biology · doi:10.1016/0022-2836(90)90371-r · Cited by 73

Overexpression of p53 gene in head-and-neck cancer, linked with heavy smoking and drinking

Field, J. K., Spandidos, D. A., & Stell, P. M. (1992) · The Lancet · doi:10.1016/0140-6736(92)91122-o · Cited by 73

UV-Induced Cutaneous Photobiology

Beissert, S., & Granstein, R. D. (1996) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239609108723 · Cited by 72

Rare occurrence of P53 gene mutations in multiple myeloma

Preudhomme, C., Facon, T. T. F., Zandecki, M., Vanrumbeke, M., Laı̈, J. L., Nataf, E., Loucheux‐Lefebvre, M. H., Kerckaert, J. P., & Fenaux, P. (1992) · British Journal of Haematology · doi:10.1111/j.1365-2141.1992.tb08253.x · Cited by 73

SirT3 and p53 Deacetylation in Aging and Cancer

Chen, J., Wang, A., & Chen, Q. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25669 · Cited by 73

Respiratory Syncytial Virus Decreases p53 Protein to Prolong Survival of Airway Epithelial Cells

Groskreutz, D. J., Monick, M. M., Yarovinsky, T. O., Powers, L. S., Quelle, D. E., Varga, S. M., Look, D. C., & Hunninghake, G. W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.2741 · Cited by 71

Correlation between p53 over expression and response to bacillus Calmette-Guerin therapy in a high risk select population of patients with T1G3 bladder cancer.

Lebrét, T., Becette, V., Barbagelatta, M., Hervé, J.-M., Gaudez, F., Barré, P., Lugagne, P., & Botto, H. (1998) · PubMed · Cited by 72

p53 immunoreactivity in human malignant melanoma and dysplastic naevi

McGregor, J. M., Yu, C. C. ‐., DUBLIN, E. A., Barnes, D. M., Levison, D. A., & MACDONALD, D. M. (1993) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1993.tb00253.x · Cited by 72

The molecular biology of breast cancer

van de Vijver, M. J., & Nusse, R. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(91)90005-6 · Cited by 73

The Genetics of Wilms' Tumor

Haber, D. A., & Housman, D. E. (1992) · Advances in cancer research · doi:10.1016/s0065-230x(08)60302-4 · Cited by 72

Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization

LaRose, A., Dyson, N. J., Sullivan, M., Harlow, E., & Bastin, M. (1991) · Journal of Virology · doi:10.1128/jvi.65.5.2308-2313.1991 · Cited by 71

Phosphorylation sites in the amino-terminal region of mouse p53.

Wang, Y., & Eckhart, W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4231 · Cited by 72

Caloric restriction: is mammalian life extension linked to p53?

Tucci, P. (2012) · Aging · doi:10.18632/aging.100481 · Cited by 70

Prognostic Significance of TP53 Tumor Suppressor Gene Expression and Mutations in Human Osteosarcoma

Pakos, E. E., Kyzas, P., & Ioannidis, J. P. A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0246 · Cited by 71

p53 Expression and DNA ploidy of cartilage lesions

Coughlan, B., Feliz, A., Ishida, T., Czerniak, B. A., & Dorfman, H. D. (1995) · Human Pathology · doi:10.1016/0046-8177(95)90166-3 · Cited by 71

TP53 mutations in familial breast cancer: Functional aspects

Gasco, M., Yuluğ, I. G., & Crook, T. (2003) · Human Mutation · doi:10.1002/humu.10173 · Cited by 71

Endogenous p53 Protein Generated from Wild-Type Alternatively Spliced p53 RNA in Mouse Epidermal Cells

Kulesz-Martin, M. F., Lisafeld, B., Huang, H., Kisiel, N. D., & Lee, L. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1698 · Cited by 71

p53: From Fundamental Biology to Clinical Applications in Cancer

Capuozzo, M., Santorsola, M., Bocchetti, M., Perri, F., Cascella, M., Granata, V., Celotto, V., Gualillo, O., Cossu, A. M., Nasti, G., et al. (2022) · Biology · doi:10.3390/biology11091325 · Cited by 74

Inhibition of p53 DNA Binding Function by the MDM2 Protein Acidic Domain

Cross, B. L., Chen, L., Cheng, Q., Li, B., Yuan, Z.-M., & Chen, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.228981 · Cited by 72

p53 gene status and expression of p53, MDM2, and p14ARF proteins in ameloblastomas

Kumamoto, H., Izutsu, T., Ohki, K., Takahashi, N., & Ooya, K. (2004) · Journal of Oral Pathology and Medicine · doi:10.1111/j.0904-2512.2004.00044.x · Cited by 70

Frequent K‐ras mutations and absence of p53 mutations in mucin‐producing tumors of the pancreas

Hoshi, T., Imai, M., & Ogawa, K. (1994) · Journal of Surgical Oncology · doi:10.1002/jso.2930550205 · Cited by 70

Constitutive Expression of the Cyclin-dependent Kinase Inhibitor p21 Is Transcriptionally Regulated by the Tumor Suppressor Protein p53

Tang, H.-Y. J., Zhao, K., Pizzolato, J. F., Fonarev, M., Langer, J., & Manfredi, J. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.29156 · Cited by 70

Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity

Sedman, S. A., Hubbert, N. L., Vass, W. C., Lowy, D. R., & Schiller, J. T. (1992) · Journal of Virology · doi:10.1128/jvi.66.7.4201-4208.1992 · Cited by 70

p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression.

Ruiz‐Lozano, P., Hixon, M. L., Wagner, M. W., Flores, A. I., Ikawa, S., Baldwin, A. S., Chien, K. R., & Gualberto, A. (1999) · PubMed · Cited by 69

Small Molecule Antagonists of the MDM2 Oncoprotein as Anticancer Agents

Buolamwini, J. K., Addo, J. K., Kamath, S., Patil, S. A., Mason, M., & Ores, M. (2005) · Current Cancer Drug Targets · doi:10.2174/1568009053332672 · Cited by 69

Virus-Host Interactions and the Pathogenesis of Murine and Human Oncogenic Retroviruses

Tsichlis, P. N., & Lazo, P. A. (1991) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-76524-7_5 · Cited by 69

Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer

Caponio, V. C. A., Troiano, G., Adipietro, I., Zhurakivska, K., Arena, C., Mangieri, D., Mascitti, M., Cirillo, N., & Muzio, L. L. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0984-6 · Cited by 68

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis

Carr, M. I., & Jones, S. N. (2016) · Translational Cancer Research · doi:10.21037/tcr.2016.11.75 · Cited by 71

Inhibition of p53 Protein Phosphorylation by 9‐Hydroxyellipticine: A Possible Anticancer Mechanism

Ohashi, M., Sugikawa, E., & Nakanishi, N. (1995) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1995.tb03091.x · Cited by 68

Analysis of mutant P53 protein in osteosarcomas and other malignant and benign lesions of bone

Ueda, Y., Dockhorn‐Dworniczak, B., Blasius, S., Mellin, W., Wuisman, P. I. J. M., B�cker, W., & Roessner, A. (1993) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01229533 · Cited by 68

Alteration of p53 gene in ovarian carcinoma: clinicopathological correlation and prognostic significance

Niwa, K., Itoh, M., MURASE, T., Morishita, S., Itoh, N., Mori, H., & Tamaya, T. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.472 · Cited by 68

Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.

Shaulian, E., Zauberman, A., Milner, J., Davies, E. A., & Oren, M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05940.x · Cited by 69

Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cells is mediated by lower p53 levels.

Ronen, D., Schwartz, D., Teitz, Y., Goldfinger, N., & Rotter, V. (1996) · PubMed · Cited by 68

Role of Dietary Antioxidants in p53‐Mediated Cancer Chemoprevention and Tumor Suppression

Merlin, J. P. J., Rupasinghe, H. P. V., Dellaire, G., & Murphy, K. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9924328 · Cited by 69

The properties of p53 proteins selected for the loss of suppression of transformation.

Olson, D., & Levine, A. J. (1994) · PubMed · Cited by 23

Wild-type p53 can inhibit oncogene-mediated focus formation.

Eliyahu, D., Michalovitz, D., Eliyahu, S., Pinhasi-Kimhi, O., & Oren, M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8763 · Cited by 687

The p53 tumor suppressor gene and gene product.

Levine, A. J. (1989) · PubMed · Cited by 57

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

Raycroft, L., Wu, H., & Lozano, G. (1990) · Science · doi:10.1126/science.2144364 · Cited by 620

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

Hinds, P. W., Finlay, C. A., & Levine, A. J. (1989) · Journal of Virology · doi:10.1128/jvi.63.2.739-746.1989 · Cited by 595