Cited by 1,987Cancer-related Molecular PathwaysCell death mechanisms and regulationPI3K/AKT/mTOR signaling in cancer

The DOI matches its Crossref record; 60 of the 70 references it cites were found in a registry or an index.

The p53 proto-oncogene can act as a suppressor of transformation

Finlay, Cathy A., Hinds, Philip W., Levine, Arnold J.·1989·Cell

Open this paper in CoChat — free account

Abstract

DNA clones of the wild-type p53 proto-oncogene inhibit the ability of E1A plus ras or mutant p53 plus ras-activated oncogenes to transform primary rat embryo fibroblasts. The rare clones of transformed foci that result from E1A plus ras plus wild-type p53 triple transfections all contain the p53 DNA in their genome, but the great majority fail to express the p53 protein. The three cell lines derived from such foci that express p53 all produce mutant p53 proteins with properties similar or identical to transformation-activated p53 proteins. The p53 mutants selected in this fashion (transformation in vitro) resemble the p53 mutants selected in tumors (in vivo). These results suggest that the p53 proto-oncogene can act negatively to block transformation.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(89)90045-7

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A new technique for the assay of infectivity of human adenovirus 5 DNA
Graham, F. L., & van der Eb, A. J. (1973) · Virology · doi:10.1016/0042-6822(73)90341-3 · Cited by 9,302
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.
Southern, P. J., & Berg, P. R. (1982) · PubMed · Cited by 2,740
T antigen is bound to a host protein in SY40-transformed cells
Lane, D. P., & Crawford, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,456
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
Linzer, D. I. H., & Levine, A. J. (1979) · Cell · doi:10.1016/0092-8674(79)90293-9 · Cited by 1,814
Self-citation
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
DeCaprio, J. A., Ludlow, J. W., Figge, J., Shew, J.-Y., Huang, C.-M., Lee, W.-H., Marsilio, E., Paucha, E., & Livingston, D. M. (1988) · Cell · doi:10.1016/0092-8674(88)90559-4 · Cited by 1,459
Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence
Lee, W., Bookstein, R., Hong, F., Young, L.-J., Shew, J., & Lee, E. Y.-H. P. (1987) · Science · doi:10.1126/science.3823889 · Cited by 1,417
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product
Whyte, P., Buchkovich, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A., & Harlow, E. (1988) · Nature · doi:10.1038/334124a0 · Cited by 1,403
Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
Ruley, H. E. (1983) · Nature · doi:10.1038/304602a0 · Cited by 1,248

Show all 70 references

Sorted by citations

Items 601–700 of 999

Association between the cellular p53 and the adenovirus 5 E1B‐55kd proteins reduces the oncogenicity of Ad‐transformed cells.
van den Heuvel, S., van Laar, T., Kast, W. M., Melief, C. J. M., ZANTEMA, A., & van der Eb, A. J. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07444.x · Cited by 67
Prognosis is correlated with p53 mutation type for soft tissue sarcoma patients.
Taubert, H. W., Meye, A., & Würl, P. (1996) · PubMed · Cited by 67
Ras activation of genes: Mob-1 as a model.
Liang, P., Averboukh, L., Zhu, W., & Pardee, A. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12515 · Cited by 67
p53 and Cell Cycle Proteins Participate in Spinal Motor Neuron Cell Death in ALS~!2010-02-16~!2010-02-19~!2010-04-14~!
Ranganathan, S., & Bowser, R. P. (2010) · The Open Pathology Journal · doi:10.2174/1874375701004010011 · Cited by 66
Plasma transforming growth factor-β1 in patients with hepatocellular carcinoma. Comparison with chronic liver diseases
Shirai, Y., Kawata, S., Tamura, S., Ito, N., Tsushima, H., Takaishi, K., Kiso, S., & Matsuzawa, Y. (1994) · Cancer · doi:10.1002/1097-0142(19940501)73:9 · Cited by 214
Regulation of the mdm2 Oncogene by Thyroid Hormone Receptor
Qi, J.-S., Yuan, Y., Desai-Yajnik, V., & Samuels, H. H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.864 · Cited by 65
Abnormalp53 immunoreactivity and prognosis in node-negative breast carcinomas with long-term follow-up
Bòsari, S., Lee, A. K. C., Viale, G., Heatley, G. J., & Coggi, G. (1992) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01660975 · Cited by 66
Architectural Accommodation in the Complex of Four p53 DNA Binding Domain Peptides with the p21/waf1/cip1 DNA Response Element
Nagaich, A. K., Zhurkin, V. B., Sakamoto, H., Gorin, A. A., Clore, G. M., Gronenborn, A. M., Appella, E., & Harrington, R. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.23.14830 · Cited by 66
Expression of SV-40 T antigen in the small intestinal epithelium of transgenic mice results in proliferative changes in the crypt and reentry of villus-associated enterocytes into the cell cycle but has no apparent effect on cellular differentiation programs and does not cause neoplastic transformation
Hauft, S. M., Kim, S., Gh, S., Pease, S., Rees, S., Harris, S. A., Roth, K. A., Hansbrough, J. R., Cohn, S., & Ahnen, D. J. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.4.825 · Cited by 66
Expression of p53 Protein Is an Early Event in Ultraviolet Light-Induced Cutaneous Squamous Cell Carcinogenesis
Nagano, T. (1993) · Archives of Dermatology · doi:10.1001/archderm.129.9.1157 · Cited by 66
p53’s Extended Reach: The Mutant p53 Secretome
Pavlakis, E., & Stiewe, T. (2020) · Biomolecules · doi:10.3390/biom10020307 · Cited by 66
EGFR and p53 Status of Pulmonary Pleomorphic Carcinoma: Implications for EGFR Tyrosine Kinase Inhibitors Therapy of an Aggressive Lung Malignancy
Chang, Y., Wu, C., Shih, J., & Lee, Y.-C. (2011) · Annals of Surgical Oncology · doi:10.1245/s10434-011-1621-7 · Cited by 65
Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness
Olivos, D. J., & Mayo, L. D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17121982 · Cited by 67
Nutlin-3, A p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment
VOON, Y.-L., Wong, P., & Khoo, A. S. B. (2017) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557517666170717125821 · Cited by 66
Post-thymic T cell lymphomas frequently overexpress p53 protein but infrequently exhibit p53 gene mutations.
Matsushima, A. Y., Cesarman, E., Chadburn, A., & Knowles, D. M., II (1994) · PubMed Central · Cited by 65
p53 protein accumulation in European hepatocellular carcinoma is not always dependent on p53 gene mutation
Bourdon, J., D’Errico, A., Paterlini-Bréchot, P., Grigioni, W., May, E., & Debuire, B. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90217-1 · Cited by 65
Correlated abnormalities of transforming growth factor-β1 response and p53 expression in thyroid epithelial cell transformation
Wyllie, F. S., Dawson, T., BOND, J. A., Goretzki, P. E., Game, S. M., Prime, S. S., & Wynford‐Thomas, D. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90255-q · Cited by 65
Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis
Foti, A., Ahuja, H., Allen, S. L., Koduru, P. R. K., Schuster, M., Schulman, P., Bar‐Eli, M., & Cline, M. (1991) · Blood · doi:10.1182/blood.v77.11.2441.2441 · Cited by 65
The history of p53
Soussi, T. (2010) · EMBO Reports · doi:10.1038/embor.2010.159 · Cited by 64
Clinical Significance of mdm2 and p53 Expression in Bladder Cancer
Shiina, H., Igawa, M., Shigeno, K., Yamasaki, Y., Urakami, S., Yoneda, T., Wada, Y., Honda, S., & Nagasaki, M. (1999) · Oncology · doi:10.1159/000011971 · Cited by 64
Perianal Bowen's disease
Beck, D. E., Fazio, V. W., Jagelman, D. G., & Lavery, I. C. (1988) · Diseases of the Colon & Rectum · doi:10.1007/bf02552608 · Cited by 64
Expression of p53 in oral mucosal hyperplasia, dysplasia and squamous cell carcinoma
Kerdpon, D., Rich, A., & Reade, P. (1997) · Oral Diseases · doi:10.1111/j.1601-0825.1997.tb00018.x · Cited by 64
Viral oncoprotein binding to pRB, p107, p130, and p300
Ludlow, J. W., & Skuse, G. R. (1995) · Virus Research · doi:10.1016/0168-1702(94)00094-s · Cited by 64
Detection of apoptosis‐related factors and apoptotic cells in ameloblastomas: analysis by immunohistochemistry and an in situ DNA nick end‐labelling method
Kumamoto, H. (1997) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.1997.tb00242.x · Cited by 64
Expression from the murine p53 promoter is mediated by factor binding to a downstream helix-loop-helix recognition motif.
Ronen, D., Rotter, V., & Reisman, D. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4128 · Cited by 63
Dominant Oncogenes and Tumor Suppressor Genes in the Pathogenesis of Lung Cancer
Viallet, J., & Minna, J. D. (1990) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/2.3.225 · Cited by 64
Mutant p53 Tumor Suppressor Alleles Release ras -Induced Cell Cycle Growth Arrest
Hicks, G. G., Egan, S. E., Greenberg, A. H., & Mowat, M. R. A. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.3.1344 · Cited by 63
Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells
Sayed, M., Pelech, S., Wong, C., Marotta, A., & Salh, B. S. (2001) · Oncogene · doi:10.1038/sj.onc.1204894 · Cited by 62
Correlation of metabolic stability and altered quaternary structure of oncoprotein p53 with cell transformation
Kraiss, S., Spieß, S., Reihsaus, E., & Montenarh, M. (1991) · Experimental Cell Research · doi:10.1016/0014-4827(91)90170-y · Cited by 63
Genetic Alteration of p53 in Some Patients with Adult T‐Cell Leukemia
Nagai, H., Kinoshita, T., Imamura, J., Murakami, Y., Hayashi, K., Mukai, K., Ikeda, S., Tobinai, K., Saito, H., Shimoyama, M., et al. (1991) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1991.tb01815.x · Cited by 64
Inosine-5′-Monophosphate Dehydrogenase Is a Rate-determining Factor for p53-dependent Growth Regulation
Liu, Y., Bohn, S. A., & Sherley, J. L. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.1.15 · Cited by 63
Formation and repair of DNA lesions in thep53 gene: Relation to cancer mutations?
Pfeifer, G. P., & Denissenko, M. F. (1998) · Environmental and Molecular Mutagenesis · doi:10.1002/(sici)1098-2280(1998)31:3 · Cited by 63
Immunohistochemical analysis of p53 and HER-2/neu proteins in human tumors.
Chang, K., Ding, I., Kern, F. G., & Willingham, M. C. (1991) · Journal of Histochemistry & Cytochemistry · doi:10.1177/39.9.1680897 · Cited by 63
RE: Heat Shock Proteins: Their Role in Urological Tumors
Pomara, G., & Cappello, F. (2003) · The Journal of Urology · doi:10.1097/01.ju.0000080564.23671.32 · Cited by 63
Prognostic biomarkers in squamous cell carcinoma of the anus: a systematic review
Lampejo, T., Kavanagh, D. O., Clark, J., Goldin, R. D., Osborn, M., Ziprin, P., & Cleator, S. J. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605984 · Cited by 62
Induction of genetic instability by gain-of-function p53 cancer mutants
Xu, Y. (2008) · Oncogene · doi:10.1038/sj.onc.1211023 · Cited by 63
Expression of Polo-Like Kinase 1 (PLK1) Protein Predicts the Survival of Patients with Gastric Carcinoma
Kanaji, S., Saito, H., Tsujitani, S., Matsumoto, S., Tatebe, S., Kondo, A., Ozaki, M., Ito, H., & Ikeguchi, M. (2006) · Oncology · doi:10.1159/000093003 · Cited by 62
Identification of T- and B-cell epitopes of the E7 protein of human papillomavirus type 16
Comerford, S. A., McCance, D. J., Dougan, G., & Tite, J. P. (1991) · Journal of Virology · doi:10.1128/jvi.65.9.4681-4690.1991 · Cited by 62
Bacillus Calmette-Guérin mycobacteria stimulate human blood dendritic cells
Thurnher, M., Ramoner, R. E., Gastl, G. A., Radmayr, C., Böck, G., Herold, M., Klocker, H., & Bartsch, G. H. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970106)70:1 · Cited by 120
Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells.
Bruening, W., Prowse, A. H., Schultz, D., Holgado-Madruga, M., Wong, A. J., & Godwin, A. K. (1999) · PubMed · Cited by 62
Immunohistochemical analysis of p53 protein overexpression in normal, premalignant, and malignant tissues of the cervix uteri
Holm, R., Skomedal, H., Helland, Å., Kristensen, G. B., Bøsrresen, A., & Nesland, J. M. (1993) · The Journal of Pathology · doi:10.1002/path.1711690105 · Cited by 62
Abnormalities of p53 Protein Expression in Cutaneous Disorders
McNutt, N. S. (1994) · Archives of Dermatology · doi:10.1001/archderm.130.2.225 · Cited by 62
p53 Immunohistochemistry in malignant fibrous histiocytomas and other mesenchymal tumours
Soini, Y., Vähäkangas, K., Nuorva, K., Kamel, D., Lane, D. P., & Pääkkö, P. K. (1992) · The Journal of Pathology · doi:10.1002/path.1711680106 · Cited by 62
Overexpressed poly(ADP-ribose) polymerase delays the release of rat cells from p53-mediated G1 checkpoint
Węsierska‐Gądek, J., & Schmid, G. (2000) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20010101)80:1 · Cited by 62
Expression of p63 and p73 in ameloblastomas
Kumamoto, H., Ohki, K., & Ooya, K. (2005) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2005.00284.x · Cited by 61
The p53 Core Domain Is a Molten Globule at Low pH
Bom, A. P. D. A., de Freitas, M. S., Moreira, F. S., Ferraz, D., Sanches, D., Gomes, A. M. O., Valente, A. P., Cordeiro, Y., & Silva, J. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.075861 · Cited by 61
Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells
Soddu, S., Blandino, G., Citro, G., Scardigli, R., Piaggio, G., Ferber, A., Calabretta, B., & Sacchi, A. (1994) · Blood · doi:10.1182/blood.v83.8.2230.2230 · Cited by 61
p53 Protein Expression in Nevi and Melanomas
Cristofolini, M. (1993) · Archives of Dermatology · doi:10.1001/archderm.129.6.739 · Cited by 61
Comparative analysis ofp53 protein immunoreactivity in prostatic, lung and breast carcinomas
Soini, Y., Pääkkö, P. K., Nuorva, K., Kamel, D., Lane, D. P., & Vähäkangas, K. (1992) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01611179 · Cited by 61
Negative control of the helix-loop-helix family of myogenic regulators in the NFB mutant
Peterson, C. A., Gordon, H., Hall, Z. W., Paterson, B. M., & Blau, H. M. (1990) · Cell · doi:10.1016/0092-8674(90)90014-6 · Cited by 61
The cellular and molecular basis of prostate cancer
Foster, Cornford, Forsyth, Djamgoz, & Ke (1999) · British Journal of Urology · doi:10.1046/j.1464-410x.1999.00954.x · Cited by 60
Distinct Residues of Human p53 Implicated in Binding to DNA, Simian Virus 40 Large T Antigen, 53BP1, and 53BP2
Thukral, S. K., Blain, G. C., Chang, K. K. H., & Fields, S. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8315 · Cited by 60
P53 and Ki‐67 Immunoreactivity in Human Prostate Cancer and Benign Hyperplasia
Thompson, S., Mellon, K., Charlton, R., Marsh, C., Robinson, M., & Neal, D. E. (1992) · British Journal of Urology · doi:10.1111/j.1464-410x.1992.tb15632.x · Cited by 60
Mutation and protein expression of p53 in acquired immunodeficiency syndrome-related lymphomas
Nakamura, H., Said, J. W., Cw, M., & Koeffler, H. (1993) · Blood · doi:10.1182/blood.v82.3.920.920 · Cited by 60
Wild-type p53 is required for apoptosis induced by growth factor deprivation in factor-dependent leukaemic cells
Zhu, Y.-M., Bradbury, D. A., & Russell, N. H. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.85 · Cited by 60
Frequent loss of heterozygosity on chromosome 22 in hepatocellular carcinoma
Takahashi, K., Kudo, J., Ishibashi, H., Hirata, Y., & Niho, Y. (1993) · Hepatology · doi:10.1002/hep.1840170508 · Cited by 60
Familial polyposis: recent advances
Miyaki, M., Tanaka, K., Kikuchi‐Yanoshita, R., Muraoka, M., & Konishi, M. (1995) · Critical Reviews in Oncology/Hematology · doi:10.1016/1040-8428(94)00129-h · Cited by 60
Expression of p53 protein in cutaneous melanoma
Akslen, L. A., & Mørkve, O. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910520104 · Cited by 60
Clinical utility of anti-p53auto-antibody: Systematic review and focus on colorectal cancer
Suppiah, A. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i29.4651 · Cited by 62
Common genetic variants in the TP53 pathway and their impact on cancer
Barnoud, T., Parris, J. L. D., & Murphy, M. E. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz052 · Cited by 62
Accelerated neuronal differentiation induced by p53 suppression
Ferreira, A., & Kosik, K. S. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.6.1509 · Cited by 59
Increased UV‐induced SCEs but normal repair of DNA damage in p53‐deficient mouse cells
Ishizaki, K., Ejima, Y., Matsunaga, T., Hara, R., Sakamoto, A. N., Ikenaga, M., Ikawa, Y., & Aizawa, S. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910580218 · Cited by 59
Distribution of p53 and K-ras mutations in human lung cancer tissues
Gao, H. (1997) · Carcinogenesis · doi:10.1093/carcin/18.3.473 · Cited by 59
DNA damage, oncogenesis and the p53 tumour-suppressor gene
Lee, J. M., Abrahamson, J., & Bernstein, A. (1994) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(94)90267-4 · Cited by 59
Detection of loss of heterozygosity in the p53 gene in renal cell carcinoma and bladder cancer using the polymerase chain reaction
Oka, K., Ishikawa, J., Bruner, J. M., Takahashi, R., & Saya, H. (1991) · Molecular Carcinogenesis · doi:10.1002/mc.2940040104 · Cited by 59
Expression of p53 in human esophageal carcinoma: An immunohistochemical study with correlation to proliferating cell nuclear antigen expression
Sasano, H., Miyazaki, S., Goukon, Y., Nishihira, T., Sawai, T., & Nagura, H. (1992) · Human Pathology · doi:10.1016/0046-8177(92)90291-a · Cited by 59
Basic Science Review: Nitric Oxide—Releasing Prosthetic Materials
Varu, V. N., Tsihlis, N. D., & Kibbe, M. R. (2008) · Vascular and Endovascular Surgery · doi:10.1177/1538574408322752 · Cited by 59
The Tumor Suppressor p53 Is Bound to RNA by a Stable Covalent Linkage
Samad, A., & Carroll, R. B. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.3.1598 · Cited by 58
Is the p53 Gene Mutation of Prognostic Value in Hepatocellular Carcinoma After Resection?
Jeng, K. (2000) · Archives of Surgery · doi:10.1001/archsurg.135.11.1329 · Cited by 58
p53 protein expression in central nervous system neoplasms.
Barbareschi, M., Iuzzolino, P., Pennella, A., Allegranza, A., Arrigoni, G., Palma, P. D., & Doglioni, C. (1992) · Journal of Clinical Pathology · doi:10.1136/jcp.45.7.583 · Cited by 58
Molecular Genetic Changes in Human Breast Cancer
van de Vijver, M. J. (1993) · Advances in cancer research · doi:10.1016/s0065-230x(08)60954-9 · Cited by 58
Order Matters: The Order of Somatic Mutations Influences Cancer EvolutionPreprint
Kent, D. G., & Green, A. R. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a027060 · Cited by 61
Prion-like p53 Amyloids in Cancer
Navalkar, A., Ghosh, S., Pandey, S., Paul, A., Datta, D., & Maji, S. K. (2019) · Biochemistry · doi:10.1021/acs.biochem.9b00796 · Cited by 56
p53siRNA therapy reduces cell proliferation, migration and induces apoptosis in triple negative breast cancer cells
Braicu, C., Pileczki, V., Irimie, A., & Berindan‐Neagoe, I. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1688-5 · Cited by 57
The mouse equivalent of the human p53ser249 mutation p53ser246 enhances aflatoxin hepatocarcinogenesis in hepatitis B surface antigen transgenic and p53 heterozygous null mice
Ghebranious, N., & Sell, S. (1998) · Hepatology · doi:10.1002/hep.510270411 · Cited by 58
Current understanding of the biology of advanced bladder cancer
Al‐Sukhun, S., & Hussain, M. (2003) · Cancer · doi:10.1002/cncr.11289 · Cited by 57
Gain-of-function p53 mutations enhance alteration of the T-cell receptor following X-irradiation, independently of the cell cycle and cell survival.
Iwamoto, K. S., Mizuno, T., Ito, T., Tsuyama, N., Kyoizumi, S., & Seyama, T. (1996) · PubMed · Cited by 57
A mutant p53 protein is required for maintenance of the transformed phenotype in cells transformed with p53 plus ras cDNAs.
Zambetti, G. P., Olson, D., Labow, M., & Levine, A. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.3952 · Cited by 57
Self-citation
Multiple sequential molecular abnormalities in the evolution of human gliomas
Venter, D. J., & Thomas, D. G. T. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.168 · Cited by 57
Significance of angiogenesis in cancer therapy
McNamara, D. A., Harmey, J. H., Walsh, T. N., Redmond, H. P., & Bouchier‐Hayes, D. J. (1998) · British journal of surgery · doi:10.1046/j.1365-2168.1998.00816.x · Cited by 57
Mutant p53 expression in solar keratosis: an immunohistochemical study
Sim, C. S., Slater, S., & McKee, P. H. (1992) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.1992.tb01366.x · Cited by 57
A comprehensive study of p53 protein
Patil, M. R., & Bihari, A. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30331 · Cited by 57
p53 Mutations and Other Prognostic Factors of Renal Cell Carcinoma
Girgin, C., Tarhan, H., Hekimgil, M., SEZER, A., & Gürel, G. (2001) · Urologia Internationalis · doi:10.1159/000056575 · Cited by 56
Two hits revisited again
Tomlinson, I. P. M., Roylance, R. R., & Houlston, R. S. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.2.81 · Cited by 56
Analysis of the p53 and MDM‐2 gene in acute myeloid leukemia
Seliger, B., Papadileris, S., Vogel, D. W., Heß, G., Brendel, C. A., Störkel, S., örtel, J., Kolbe, K., Huber, C. H., Huhn, D., et al. (1996) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1996.tb01369.x · Cited by 56
P53 gene mutations in acute myelogenous leukaemia
Hu, G., Zhang, W., & Deisseroth, A. (1992) · British Journal of Haematology · doi:10.1111/j.1365-2141.1992.tb02979.x · Cited by 56
The spectrum of TP53 mutations in bladder carcinoma
Williamson, M. P., Elder, P. A., & Knowles, M. A. (1994) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870090206 · Cited by 56
Retinoblastoma and p53 gene product expression in breast carcinoma: Immunohistochemical analysis and clinicopathologic correlation
Trudel, M., Mulligan, L. M., Cavenee, W. K., Margolese, R. G., Côté, J., & Gariépy, G. (1992) · Human Pathology · doi:10.1016/0046-8177(92)90059-c · Cited by 56
E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53
Jung, J. H., Bae, S., Lee, J. Y., Woo, S. R., Cha, H. J., Yoon, Y., Suh, K.-S., Lee, S.-J., Park, I.-C., Jin, Y.-W., et al. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.57 · Cited by 52
Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein.
Marcellus, R. C., Teodoro, J. G., Charbonneau, R., Shore, G. C., & Branton, P. E. (1996) · PubMed · Cited by 55
Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia
Demir, S., Boldrin, E., Sun, Q., Hampp, S., Tausch, E., Eckert, C., Ebinger, M., Handgretinger, R., Kronnie, G. T., Wiesmüller, L., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.199364 · Cited by 59
Human Cytomegalovirus IE1-72 Protein Interacts with p53 and Inhibits p53-Dependent Transactivation by a Mechanism Different from That of IE2-86 Protein
Hwang, E., Zhang, Z., Cai, H., Huang, D. Y. C., Huong, S., Cha, C.-Y., & Huang, E. (2009) · Journal of Virology · doi:10.1128/jvi.00304-09 · Cited by 55
Long-term survivors of glioblastoma multiforme: clinical and molecular characteristics
Morita, M., Rosenblum, M. K., Bilsky, M. H., Fraser, R. A. R., & Rosenfeld, M. R. (1996) · Journal of Neuro-Oncology · doi:10.1007/bf00165483 · Cited by 55
Mutant p53 oncogene expression in keratoacanthoma and squamous cell carcinoma
Stephenson, T. J., Royds, J. A., Silcocks, P. B. S., & BLEEHEN, S. S. (1992) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1992.tb14866.x · Cited by 55
Analysis of p53 gene mutations in low- and high-grade astrocytomas by polymerase chain reaction-assisted single-strand conformation polymorphism and immunohistochemistry
Koga, H., Zhang, S., Kumanishi, T., Washiyama, K., Ichikawa, T., Tanaka, R., & Mukawa, J. (1994) · Acta Neuropathologica · doi:10.1007/bf00296737 · Cited by 55
Wild‐type murine p53 represses transcription from the murine c‐myc promoter in a human glial cell line
Moberg, K. H., Tyndall, W. A., & Hall, D. J. (1992) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240490213 · Cited by 55
Overexpression of wild-type p53 alters growth and differentiation of normal human keratinocytes but not human papillomavirus-expressing cell lines.
Woodworth, C. D., Wang, H., Simpson, S., Álvarez-Salas, L. M., & Notario, V. (1993) · PubMed · Cited by 56
The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death
Chari, N. S., Pinaire, N. L., Thorpe, L., Medeiros, L. J., Routbort, M. J., & McDonnell, T. J. (2009) · APOPTOSIS · doi:10.1007/s10495-009-0327-9 · Cited by 54
Analysis of p73 gene in meningiomas with deletion at 1p
Lomas, J., Bello, M. J., Arjona, D., González‐Gómez, P., Alonso, M. E., de Campos, J. M., Vaquero, J., Ruiz-Barnes, P., Sarasa, J. L., Casartelli, C., et al. (2001) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(01)00430-7 · Cited by 54
p53 protein accumulation and genomic instability in head and neck multistep tumorigenesis.
Shin, D. M., Charuruks, N., Lippman, S. M., Lee, J. J., Ro, J. Y., Hong, W. K., & Hittelman, W. N. (2001) · PubMed · Cited by 54

Authors: Finlay, C. A., Hinds, P. W., & Levine, A. J.
Affiliations: Princeton University (US)
ORCID: Hinds, Philip W.
Levine, Arnold J.
Venue: Cell
Publisher: Elsevier BV
Published: 1989-06
Volume: 57
Issue: 7
Pages: 1083-1093
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(89)90045-7
OpenAlex: W2163565167
Cited by: 1,987
References: 70
Citations by year: 2026: 14 · 2025: 12 · 2024: 25 · 2023: 27 · 2022: 20 · 2021: 34 · 2020: 37 · 2019: 31 · 2018: 29 · 2017: 29 · 2016: 28 · 2015: 12 · 2014: 28 · 2013: 26 · 2012: 38
FWCI: 79.38
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P01CA041086, P01-CA41086-03)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: tumor suppressor, oncogenic transformation, adenovirus E1A, oncogenic Ras, mutant p53, p53 expression, rat embryo fibroblasts, transformed foci, tumor suppressor function
MeSH terms: Animals, Antigens, Polyomavirus Transforming, Cell Line, Cell Transformation, Neoplastic, Cells, Cultured, Gene Expression Regulation, Neoplasm Proteins, Oncogene Proteins, Viral, Phosphoproteins, Proto-Oncogene Proteins, Genes, ras, Transfection, Tumor Suppressor Protein p53, Adenovirus Early Proteins, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The p53 proto-oncogene can act as a suppressor of transformation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks