The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues
Abstract
We have identified the regulatory sequences required for the periodic expression of the Drosophila pair rule gene even skipped (eve). We find that the gradually changing pattern of periodic eve expression during early embryogenesis is directed by two distinct regulatory programs. Initially, eve expression in individual stripes is established by different regulatory elements, each of which responds to nonperiodic spatial cues provided, at least in part, by the gap genes. Later, coordinate expression of eve in all seven stripes is directed by a single regulatory region that responds to periodic cues provided by primary pair rule genes, including eve itself. As a consequence of this two-step regulatory program, eve functions both in the establishment of the periodic pattern of gene expression and in the subsequent specification of parasegmental boundaries.
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“The stripe 2 enhancer controls eve expression in early embryogenesis via binding of tissue-specific TFs [121–123].”
From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [122]
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Cites
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Research works printed but not linked: 1
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Thanos, D., & Maniatis, T. (1995) · Cell · doi:10.1016/0092-8674(95)90136-1 · Cited by 1,014
Self-citationTools for neuroanatomy and neurogenetics in Drosophila
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Metadata
- Authors
- Goto, T., Macdonald, P., & Maniatis, T.
- Affiliations
- Harvard University (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1989-05
- Volume
- 57
- Issue
- 3
- Pages
- 413-422
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2054852170
- Cited by
- 277
- References
- 49
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 8 · 2016: 8 · 2015: 7 · 2014: 6 · 2013: 4 · 2012: 4
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01gm029301-13)
- National Institute of General Medical Sciences (1P01GM29301)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- even-skipped, pair-rule genes, Drosophila embryogenesis, gene regulatory elements, periodic gene expression, gap genes, cis-regulatory sequences, spatial patterning
- MeSH terms
- Animals, Bacterial Proteins, Cloning, Molecular, Drosophila, Gene Expression Regulation, Genes, Regulator, Promoter Regions, Genetic, Proteins, Transcription Factors, Homeodomain Proteins, Drosophila Proteins
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