Cited by 277Developmental Biology and Gene RegulationGenomics and Chromatin DynamicsGene Regulatory Network Analysis

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Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues

Goto, Tadaatsu, Macdonald, Paul, Maniatis, Tom·1989·Cell

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Abstract

We have identified the regulatory sequences required for the periodic expression of the Drosophila pair rule gene even skipped (eve). We find that the gradually changing pattern of periodic eve expression during early embryogenesis is directed by two distinct regulatory programs. Initially, eve expression in individual stripes is established by different regulatory elements, each of which responds to nonperiodic spatial cues provided, at least in part, by the gap genes. Later, coordinate expression of eve in all seven stripes is directed by a single regulatory region that responds to periodic cues provided by primary pair rule genes, including eve itself. As a consequence of this two-step regulatory program, eve functions both in the establishment of the periodic pattern of gene expression and in the subsequent specification of parasegmental boundaries.

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Authors: Goto, T., Macdonald, P., & Maniatis, T.
Affiliations: Harvard University (US)
Howard Hughes Medical Institute (US)
ORCID: Macdonald, Paul
Maniatis, Tom
Venue: Cell
Publisher: Elsevier BV
Published: 1989-05
Volume: 57
Issue: 3
Pages: 413-422
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(89)90916-1
OpenAlex: W2054852170
Cited by: 277
References: 49
Citations by year: 2026: 10 · 2025: 9 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 8 · 2016: 8 · 2015: 7 · 2014: 6 · 2013: 4 · 2012: 4
FWCI: 8.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01gm029301-13)
National Institute of General Medical Sciences (1P01GM29301)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords: even-skipped, pair-rule genes, Drosophila embryogenesis, gene regulatory elements, periodic gene expression, gap genes, cis-regulatory sequences, spatial patterning
MeSH terms: Animals, Bacterial Proteins, Cloning, Molecular, Drosophila, Gene Expression Regulation, Genes, Regulator, Promoter Regions, Genetic, Proteins, Transcription Factors, Homeodomain Proteins, Drosophila Proteins

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Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues

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