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A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells
Open accessAbstract
Hematopoietic stem cells (HSCs) isolated from mouse fetal liver, like adult HSCs, are Thy-1lo Lin- Sca-1+. Donor-derived V gamma 3+ T cells were detected in fetal thymic lobes repopulated in vitro with fetal liver HSCs, but not in those with adult bone marrow HSCs. Single clonogenic fetal HSCs gave rise to thymic progeny that include V gamma 3+, other gamma delta+, and alpha beta+ T cells. No V gamma 3+ T cells were detected in adult thymus injected intrathymically with either fetal or adult HSCs. These results support the hypothesis that only fetal HSCs have the capacity to differentiate into V gamma 3+ T cells in the fetal thymic microenvironment and that the developmental potential of HSCs may change during ontogeny.
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“It has long been recognized that the earliest fetal thymocytes are different from later waves of developing thymocytes in terms of their abilities to generate particular classes of TCRγδ cells (134) and in terms of their extremely fast differentiation kinetics, both in vivo and in fetal thymic organ culture or stromal coculture systems (104, 133, 135).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [134]
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Metadata
- Authors
- Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y.-H., & Weissman, I. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- Kyoto University (JP)
- Stanford Medicine (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1990-09
- Volume
- 62
- Issue
- 5
- Pages
- 863-874
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2008661167
- Cited by
- 583
- References
- 51
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 7 · 2020: 17 · 2019: 10 · 2018: 5 · 2017: 9 · 2016: 10 · 2015: 10 · 2014: 9 · 2013: 11 · 2012: 15
- FWCI
- 21.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r35ca042551-13)
- National Cancer Institute (CA 42551)
- National Institute of Allergy and Infectious Diseases (AI 09072)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- hematopoietic stem cells, fetal liver, γδ T cells, alpha beta T cells, fetal thymus, thymic microenvironment, ontogeny, developmental potential, Sca-1, CD90, clonogenic activity
- MeSH terms
- Animals, Antibodies, Monoclonal, Antigens, Differentiation, T-Lymphocyte, Base Sequence, Bone Marrow, Cell Differentiation, Cell Division, Colony-Forming Units Assay, Fetus, Flow Cytometry, Hematopoietic Stem Cells, Liver, Mice, Inbred C57BL, Molecular Sequence Data, Organ Culture Techniques, Phenotype, Poly A, Receptors, Antigen, T-Cell, RNA, Messenger, Spleen, T-Lymphocytes, Oligonucleotide Probes, Polymerase Chain Reaction, CD8 Antigens, CD3 Complex, Mice
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