Cited by 518Cellular transport and secretionProtein Structure and DynamicsReceptor Mechanisms and Signaling

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Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

Collawn, James F., Stangel, Martin, Kuhn, Leslie A., Esekogwu, Victor, Jing, Shuqian, Trowbridge, Ian S., Tainer, John A.·1990·Cell

DOI 10.1016/0092-8674(90)90509-d

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Abstract

Using detailed functional studies on 24 human transferrin receptor mutants, we identified YXRF as the internalization sequence. Provided that at least 7 residues separate this tetrapeptide from the transmembrane region, changing the tetrapeptide position within the TR cytoplasmic domain does not reduce internalization activity. Thus, any conformational determinant for internalization must be localized to the YXRF sequence. Twenty-eight tetrapeptide analogs of YXRF, found by an unbiased search of all known three-dimensional protein structures, significantly favored tight turns similar to a type I turn. Of the ten tetrapeptides most closely related to YXRF, eight were surface exposed and had tight-turn conformations, as were four of five tetrapeptides with sequences related to the low density lipoprotein receptor internalization motif, NPXY. The internalization sequences of both receptors contain aromatic residues with intervening hydrogen-bonding residues. Thus, two distinct internalization sequences favor a common structural chemistry and implicate an exposed tight turn as the recognition motif for high efficiency endocytosis.

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DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
The protein data bank: A computer-based archival file for macromolecular structures
Bernstein, F. C., Koetzle, T. F., Williams, G. J. B., Meyer, E. F., Brice, M. D., Rodgers, J. R., Kennard, O., Shimanouchi, T., & Tasumi, M. (1977) · Journal of Molecular Biology · doi:10.1016/s0022-2836(77)80200-3 · Cited by 8,574
Rapid and efficient site-specific mutagenesis without phenotypic selection.
Kunkel, T. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.2.488 · Cited by 7,309
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
A new approach to variable metric algorithms
Fletcher, R. (1970) · The Computer Journal · doi:10.1093/comjnl/13.3.317 · Cited by 4,230
The Anatomy and Taxonomy of Protein Structure
Richardson, J. S. (1981) · Advances in protein chemistry · doi:10.1016/s0065-3233(08)60520-3 · Cited by 3,378
Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy
Henderson, R. A., Baldwin, J. M., Ceska, T. A., Zemlin, F., Beckmann, E., & Downing, K. H. (1990) · Journal of Molecular Biology · doi:10.1016/s0022-2836(05)80271-2 · Cited by 2,982
Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence
Chou, P. Y., & Fasman, G. D. (1979) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470122921.ch2 · Cited by 2,917
Solvent-Accessible Surfaces of Proteins and Nucleic Acids
Connolly, M. L. (1983) · Science · doi:10.1126/science.6879170 · Cited by 2,759
Analytical molecular surface calculation
Connolly, M. L. (1983) · Journal of Applied Crystallography · doi:10.1107/s0021889883010985 · Cited by 2,521

Show all 68 references

Research works printed but not linked: 1

Cauchy, 1847, Méthode générale pour la résolution des systèmes d'équations simultanées, C. R. Hebd. Seances Acad. Sci., 25, 536

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Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice
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Allevato, G., Billestrup, N., Goujon, L., Galsgaard, E. D., Norstedt, G., Postel-Vinay, M. C., Kelly, P. A., & Nielsen, J. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17210 · Cited by 84
Related signals for endocytosis and basolateral sorting of the asialoglycoprotein receptor.
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Reconstitution of clathrin-coated pit budding from plasma membranes.
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Association of the transmembrane TGF-alpha precursor with a protein kinase complex.
Shum, L., Reeves, S. A., Kuo, A. C., Fromer, E. S., & Derynck, R. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.4.903 · Cited by 83
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Mutational analysis of insulin receptor function
Tavaré, J. M., & Siddle, K. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(93)90106-y · Cited by 80
The Many Roles of the Class A Macrophage Scavenger Receptor
Platt, N., Haworth, R., Darley, L., & Gordon, S. (2002) · International review of cytology · doi:10.1016/s0074-7696(01)12002-4 · Cited by 81
Insulin receptor internalization: molecular mechanisms and physiopathological implications
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Expression of the influenza A virus M2 protein is restricted to apical surfaces of polarized epithelial cells
Hughey, P. G., Compans, R. W., Zebedee, S. L., & Lamb, R. A. (1992) · Journal of Virology · doi:10.1128/jvi.66.9.5542-5552.1992 · Cited by 80
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A Di-Leucine Sequence and a Cluster of Acidic Amino Acids Are Required for Dynamic Retention in the Endosomal Recycling Compartment of Fibroblasts
Johnson, A. O., Lampson, M. A., & McGraw, T. E. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.2.367 · Cited by 80
Regulation of the avidity of integrin alpha 4 beta 7 by the beta 7 cytoplasmic domain.
Crowe, D. T., Chiu, H., Fong, S., & Weissman, I. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36638-3 · Cited by 80
The Carboxyl Terminus of the Cystic Fibrosis Transmembrane Conductance Regulator Binds to AP-2 Clathrin Adaptors
Weixel, K. M., & Bradbury, N. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3655 · Cited by 79
The amino terminus of GLUT4 functions as an internalization motif but not an intracellular retention signal when substituted for the transferrin receptor cytoplasmic domain
Garippa, R., Judge, T., James, D., & McGraw, T. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.5.705 · Cited by 79
Recruitment of epidermal growth factor and transferrin receptors into coated pits in vitro: differing biochemical requirements.
Lamaze, C., Baba, T., Redelmeier, T. E., & Schmid, S. L. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.7.715 · Cited by 78
Src Regulates Tyr20 Phosphorylation of Transferrin Receptor-1 and Potentiates Breast Cancer Cell Survival
Jian, J., Yang, Q., & Huang, X. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.271585 · Cited by 78
Tryptophan- and Dileucine-based Endocytosis Signals in the Neonatal Fc Receptor
Wu, Z., & Simister, N. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006684200 · Cited by 77
Role of Amino Acid Sequences Flanking Dibasic Cleavage Sites in Precursor Proteolytic Processing. The Importance of the First Residue C-Terminal of the Cleavage Site
Rholam, M., Brakch, N., Germain, D., Thomas, D. Y., Fahy, C., Boussetta, H., Boileau, G., & Cohen, P. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20192.x · Cited by 77
Incorporation of homologous and heterologous proteins into the envelope of Moloney murine leukemia virus
Suomalainen, M., & Garoff, H. (1994) · Journal of Virology · doi:10.1128/jvi.68.8.4879-4889.1994 · Cited by 77
Complex Formation Facilitates Endocytosis of the Varicella-Zoster Virus gE:gI Fc Receptor
Olson, J. K., & Grose, C. F. (1998) · Journal of Virology · doi:10.1128/jvi.72.2.1542-1551.1998 · Cited by 77
Roles for a Cytoplasmic Tyrosine and Tyrosine Kinase Activity in the Interactions of Neu Receptors with Coated Pits
Gilboa, L., Ben-Levy, R., Yarden, Y., & Henis, Y. I. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7061 · Cited by 76
TOSO, the Fcμ Receptor, Is Highly Expressed on Chronic Lymphocytic Leukemia B Cells, Internalizes upon IgM Binding, Shuttles to the Lysosome, and Is Downregulated in Response to TLR Activation
Vire, B., David, A., & Wiestner, A. U. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100532 · Cited by 73
Selective membrane protein trafficking: vectorial flow and filter
Hopkins, C. R. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90423-7 · Cited by 73
Intracellular distribution of the Wilson’s disease gene product (atpase7b) after in vitro and in vivo exogenous expression in hepatocytes from the LEC rat, an animal model of Wilson’s disease
Nagano, K., Nakamura, K., Urakami, K.-I., Umeyama, K., Uchiyama, H., Koiwai, K., Hattori, S., Yamamoto, T., Matsuda, I., & Endo, F. (1998) · Hepatology · doi:10.1002/hep.510270323 · Cited by 71
Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia
Coulon, S., Dussiot, M., Grapton, D., Maciel, T. T., Wang, P. H. M., Callens, C., Tiwari, M. K., Agarwal, S., Fricot, A., Vandekerckhove, J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2462 · Cited by 70
Cholesterol-Binding Viral Proteins in Virus Entry and Morphogenesis
Schroeder, C. (2010) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-8622-8_3 · Cited by 71
The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV.
Lehmann, L., Eberle, W., Krull, S., Prill, V., Schmidt, B., Sander, C., FIGURA, K. V., & Peters, C. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05539.x · Cited by 70
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Geisler, C., Dietrich, J., Nielsen, B. L., Kastrup, J., Lauritsen, J. P. H., Ødum, N., & Christensen, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.21316 · Cited by 69
Monoclonal antibodies against defined epitopes of the human transferrin receptor cytoplasmic tail
White, S., Miller, K., Hopkins, C. R., & Trowbridge, I. S. (1992) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(92)90081-l · Cited by 68
Self-citation
Topical Review
Okamoto, C. T., & Forte, J. G. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0287f.x · Cited by 67
Growth Hormone Receptor Ubiquitination Coincides with Recruitment to Clathrin-coated Membrane Domains
van Kerkhof, P., Sachse, M., Klumperman, J., & Strous, G. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007326200 · Cited by 67
Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation.
Pennica, D., Lam, V. T., Mize, N. K., Weber, R. F., Lewis, M., FENDLY, B. M., Lipari, M. T., & Goeddel, D. V. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36813-9 · Cited by 67
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Mojarad-Jabali, S., Mahdinloo, S., Farshbaf, M., Sarfraz, M., Fatahi, Y., Atyabi, F., & Valizadeh, H. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2083106 · Cited by 69

Authors: Collawn, J. F., Stangel, M., Kuhn, L. A., Esekogwu, V., Jing, S., Trowbridge, I. S., & Tainer, J. A.
Affiliations: Salk Institute for Biological Studies (US)
Scripps Clinic (US)
Scripps Research Institute (US)
ORCID: Collawn, James F.
Stangel, Martin
Kuhn, Leslie A.
Tainer, John A.
Venue: Cell
Publisher: Elsevier BV
Published: 1990-11
Volume: 63
Issue: 5
Pages: 1061-1072
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(90)90509-d
OpenAlex: W2067691363
Cited by: 518
References: 68
Citations by year: 2026: 4 · 2025: 7 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 10 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 8 · 2014: 3 · 2013: 4 · 2012: 7
FWCI: 19.63
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Arthritis Foundation
National Institutes of Health (5r01ca034787-11)
National Cancer Institute (CA 34787)
National Institute of Diabetes and Digestive and Kidney Diseases (DK07022, T32DK007022)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: transferrin receptor, endocytosis, NPXY motif, LDL receptor, aromatic residues, hydrogen bonding, cytoplasmic domain, receptor internalization
MeSH terms: Amino Acid Sequence, Animals, Cell Membrane, Chick Embryo, Chromosome Deletion, Cytoplasm, Endocytosis, Fibroblasts, Humans, Kinetics, Models, Molecular, Molecular Sequence Data, Protein Conformation, Receptors, LDL, Receptors, Transferrin, Sequence Homology, Nucleic Acid, Transfection, Mutagenesis, Site-Directed

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Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

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