Cited by 2,276Hair Growth and DisordersSkin and Cellular Biology ResearchCancer and Skin Lesions

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Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis

Cotsarelis, George, Sun, Tung-Tien, Lavker, Robert M.·1990·Cell

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Abstract

Inconsistent with the view that hair follicle stem cells reside in the matrix area of the hair bulb, we found that label-retaining cells exist exclusively in the bulge area of the mouse hair follicle. The bulge consists of a subpopulation of outer root sheath cells located in the midportion of the follicle at the arrector pili muscle attachment site. Keratinocytes in the bulge area are relatively undifferentiated ultrastructurally. They are normally slow cycling, but can be stimulated to proliferate transiently by TPA. Located in a well-protected and nourished environment, these cells mark the lower end of the "permanent" portion of the follicle. Our findings, plus a reevaluation of the literature, suggest that follicular stem cells reside in the bulge region, instead of the lower bulb. This new view provides insights into hair cycle control and the possible involvement of hair follicle stem cells in skin carcinogenesis.

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Authors: Cotsarelis, G., Sun, T.-T., & Lavker, R. M.
Affiliations: University of Pennsylvania (US)
New York University (US)
ORCID: Cotsarelis, George
Sun, Tung-Tien
Lavker, Robert M.
Venue: Cell
Publisher: Elsevier BV
Published: 1990-06
Volume: 61
Issue: 7
Pages: 1329-1337
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(90)90696-c
OpenAlex: W1980332250
Cited by: 2,276
References: 84
Citations by year: 2026: 22 · 2025: 23 · 2024: 39 · 2023: 35 · 2022: 48 · 2021: 57 · 2020: 68 · 2019: 65 · 2018: 59 · 2017: 69 · 2016: 60 · 2015: 75 · 2014: 91 · 2013: 102 · 2012: 120
FWCI: 56.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ar034511-08, 5p01ar039674-05)
National Eye Institute (EY 06769)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 39674, AR34511)
Topics: Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
Keywords: label-retaining cells, hair follicle bulge, hair follicle stem cells, pilosebaceous unit, outer root sheath, arrector pili muscle, hair cycle, skin carcinogenesis, keratinocyte proliferation
MeSH terms: Animals, Animals, Newborn, Cell Cycle, Cell Division, Cells, Cultured, Hair, Mice, Inbred Strains, Microscopy, Electron, Skin Neoplasms, Tetradecanoylphorbol Acetate, Thymidine, Mice

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Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis

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