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Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis
Abstract
Inconsistent with the view that hair follicle stem cells reside in the matrix area of the hair bulb, we found that label-retaining cells exist exclusively in the bulge area of the mouse hair follicle. The bulge consists of a subpopulation of outer root sheath cells located in the midportion of the follicle at the arrector pili muscle attachment site. Keratinocytes in the bulge area are relatively undifferentiated ultrastructurally. They are normally slow cycling, but can be stimulated to proliferate transiently by TPA. Located in a well-protected and nourished environment, these cells mark the lower end of the "permanent" portion of the follicle. Our findings, plus a reevaluation of the literature, suggest that follicular stem cells reside in the bulge region, instead of the lower bulb. This new view provides insights into hair cycle control and the possible involvement of hair follicle stem cells in skin carcinogenesis.
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“It has been reported that slow-cycling HF stem cells reside in a bulge region of the outer root sheath located proximal to the SG (Cotsarelis et al., 1990; Lavker et al., 2003).”
From Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids (2018) · cites this paper as Cotsarelis et al., 1990
In the citing paper
“Initiation of a new anagen cycle depends upon activation of a small number of quiescent stem cells that reside in the bulge, a niche at the follicle base15–19.”
From Conditional telomerase induction causes proliferation of hair follicle stem cells (2005) · cites this paper as [15]
Citations
Cites
Cotsarelis, G., Cheng, S.-Z., Dong, G., Sun, T., & Lavker, R. M. (1989) · Cell · doi:10.1016/0092-8674(89)90958-6 · Cited by 1,429
Self-citationSchermer, A., Galvin, S., & Sun, T. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.1.49 · Cited by 1,398
Self-citationThe Structure and Function of Skin
Walters, K., & Roberts, M. S. (2002) · CRC Press eBooks · doi:10.1201/9780824743239-4 · Cited by 1,010
Induction of hair growth by implantation of cultured dermal papilla cells
Jahoda, C. A. B., Horne, K. A., & OLIVER, R. F. (1984) · Nature · doi:10.1038/311560a0 · Cited by 637
Biology of the Skin and Hair Growth
SAMS, W. M. (1966) · Archives of Dermatology · doi:10.1001/archderm.1966.01600250117031 · Cited by 609
Malaparte, C. (1988) · Cited by 601
Lajtha, L. G. (1979) · Differentiation · doi:10.1111/j.1432-0436.1979.tb01007.x · Cited by 562
Chase, H. B. (1954) · Physiological Reviews · doi:10.1152/physrev.1954.34.1.113 · Cited by 544
Stem cells: the generation and maintenance of cellular diversity
Hall, P. A., & Watt, F. M. (1989) · Development · doi:10.1242/dev.106.4.619 · Cited by 506
Ultrastructure of Normal and Abnormal Skin.
(1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-68-6-1382_1 · Cited by 480
Research works printed but not linked: 2
- Steinmuller, 1971, Re-investigation of epidermal transplantation during chemical carcinogenesis, Cancer Res., 31, 2080
- Wright, 1984, Vol. 1
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Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life
Morrison, S. J., & Spradling, A. C. (2008) · Cell · doi:10.1016/j.cell.2008.01.038 · Cited by 2,026
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
Moore, K. A., & Lemischka, I. R. (2006) · Science · doi:10.1126/science.1110542 · Cited by 1,589
Controls of Hair Follicle Cycling
Stenn, K. S., & Paus, R. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.449 · Cited by 1,543
Bi, Y., Ehirchiou, D., Kilts, T. M., Inkson, C. A., Embree, M. C., Sonoyama, W., Li, L., Leet, A. I., Seo, B., Zhang, L., et al. (2007) · Nature Medicine · doi:10.1038/nm1630 · Cited by 1,488
Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E. (2004) · Cell · doi:10.1016/j.cell.2004.08.012 · Cited by 1,428
Paus, R., & Cotsarelis, G. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908123410706 · Cited by 1,438
Self-citationMüller-Röver, S., Foitzik, K., Paus, R., Handjiski, B., van der Veen, C., Eichmüller, S., McKay, I. A., & Stenn, K. S. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01377.x · Cited by 1,375
p63 identifies keratinocyte stem cells
Pellegrini, G., Dellambra, E., Golisano, O., Martinelli, E., Fantozzi, I., Bondanza, S., Ponzin, D., McKeon, F., & Luca, M. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061032098 · Cited by 1,359
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352
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Wilson, A., & Trumpp, A. (2006) · Nature reviews. Immunology · doi:10.1038/nri1779 · Cited by 1,418
Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,317
Self-citationCapturing and profiling adult hair follicle stem cells
Morris, R. J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J. S., Sawicki, J. A., & Cotsarelis, G. (2004) · Nature Biotechnology · doi:10.1038/nbt950 · Cited by 1,283
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Werner, S., Krieg, T. M., & Smola, H. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700786 · Cited by 1,305
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Blanpain, C., & Fuchs, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2636 · Cited by 1,270
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
Li, L., & Clevers, H. (2010) · Science · doi:10.1126/science.1180794 · Cited by 1,247
STEM CELL NICHE: Structure and Function
Li, L., & Xie, T. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131525 · Cited by 1,268
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Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148
Jones, P. H., & Watt, F. M. (1993) · Cell · doi:10.1016/0092-8674(93)90251-k · Cited by 1,100
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089
Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
Taylor, G., Lehrer, M. S., Jensen, P. J., Sun, T.-T., & Lavker, R. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00050-7 · Cited by 1,070
Self-citationKnop, E., Knop, N., Millar, T., Obata, H., & Sullivan, D. A. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6997c · Cited by 1,093
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S. E., & Cotsarelis, G. (2007) · Nature · doi:10.1038/nature05766 · Cited by 1,064
Self-citationMorphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
Oshima, H., Rochat, A., Kedzia, C., Kobayashi, K., & Barrandon, Y. (2001) · Cell · doi:10.1016/s0092-8674(01)00208-2 · Cited by 1,043
The Hair Follicle as a Dynamic Miniorgan
Schneider, M. R., Schmidt-Ullrich, R., & Paus, R. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.005 · Cited by 1,119
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Costin, G.-E., & Hearing, V. J. (2007) · The FASEB Journal · doi:10.1096/fj.06-6649rev · Cited by 976
Molecular Mechanisms Regulating Hair Follicle Development
Millar, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01670.x · Cited by 967
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Jaks, V., Barker, N., Kasper, M., van Es, J. H., Snippert, H. J., Clevers, H., & Toftgård, R. (2008) · Nature Genetics · doi:10.1038/ng.239 · Cited by 966
The secret life of the hair follicle
Hardy, M. H. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90350-d · Cited by 931
Scratching the surface of skin development
Fuchs, E. (2007) · Nature · doi:10.1038/nature05659 · Cited by 930
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
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Beck, B., & Blanpain, C. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3597 · Cited by 915
Dominant role of the niche in melanocyte stem-cell fate determination
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Greco, V., Chen, T., Rendl, M., Schober, M., Pasolli, H. A., Stokes, N., dela Cruz-Racelis, J., & Fuchs, E. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.12.009 · Cited by 800
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Jones, P. H., Harper, S. J., & Watt, F. M. (1995) · Cell · doi:10.1016/0092-8674(95)90453-0 · Cited by 783
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Steinhart, Z., & Angers, S. (2018) · Development · doi:10.1242/dev.146589 · Cited by 821
Fuchs, E. V., & Segre, J. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81691-8 · Cited by 762
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St‐Jacques, B., Dassule, H. R., Karavanova, I. D., Botchkarev, V. A., Li, J., Danielian, P. S., McMahon, J. A., Lewis, P. M., Paus, R., & McMahon, A. P. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70443-9 · Cited by 764
Kretzschmar, K., & Watt, F. M. (2012) · Cell · doi:10.1016/j.cell.2012.01.002 · Cited by 756
Pellegrini, G., Golisano, O., Paterna, P., Lambìase, A., Bonini, S., Rama, P., & Luca, M. D. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.4.769 · Cited by 720
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation
Wilson, A., Murphy, M. J., Oskarsson, T., Kaloulis, K., Bettess, M. D., Oser, G. M., Pasche, A.-C., Knabenhans, C., MacDonald, H. R., & Trumpp, A. (2004) · Genes & Development · doi:10.1101/gad.313104 · Cited by 823
Lugert, S., Basak, O., Knuckles, P., Haussler, U., Fabel, K., Götz, M., Haas, C. A., Kempermann, G., Taylor, V., & Giachino, C. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.017 · Cited by 704
Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
Snippert, H. J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J. H., Barker, N., van de Wetering, M., van den Born, M., Begthel, H., Vries, R. G., et al. (2010) · Science · doi:10.1126/science.1184733 · Cited by 751
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Ali, N., Zirak, B., Rodriguez, R. S., Pauli, M. L., Truong, H.-A., Lai, K., Ahn, R., Corbin, K., Lowe, M. M., Scharschmidt, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.002 · Cited by 680
Self-citationWound Healing and Skin RegenerationPreprint
Takeo, M., Lee, W., & Ito, M. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a023267 · Cited by 715
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Li, L., & Neaves, W. B. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3986 · Cited by 686
Multistage carcinogenesis in mouse skin
DiGiovanni, J. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90051-z · Cited by 646
Intestinal stem cells protect their genome by selective segregation of template DNA strands
Potten, C. S., Owen, G., & Booth, D. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.11.2381 · Cited by 633
Dynamics between Stem Cells, Niche, and Progeny in the Hair Follicle
Hsu, Y., Pasolli, H. A., & Fuchs, E. V. (2011) · Cell · doi:10.1016/j.cell.2010.11.049 · Cited by 641
Characterization and isolation of stem cell-enriched human hair follicle bulge cells
Ohyama, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26043 · Cited by 623
Epithelial Stem Cells: Turning over New Leaves
Blanpain, C., Horsley, V., & Fuchs, E. V. (2007) · Cell · doi:10.1016/j.cell.2007.01.014 · Cited by 607
FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R. (1994) · Cell · doi:10.1016/0092-8674(94)90276-3 · Cited by 589
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells
Foudi, A., Hochedlinger, K., Van Buren, D., Schindler, J. W., Jaenisch, R., Carey, V., & Hock, H. (2009) · Nature Biotechnology · doi:10.1038/nbt.1517 · Cited by 586
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Kurtova, A. V., Xiao, J., Mo, Q., Pazhanisamy, S. K., Krasnow, R. E., Lerner, S. P., Chen, F., Roh, T. T., Lay, E. J., Ho, P. L., et al. (2014) · Nature · doi:10.1038/nature14034 · Cited by 589
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Kolarsick, P. A. J., Kolarsick, M. A., & Goodwin, C. (2011) · Journal of the Dermatology Nurses' Association · doi:10.1097/jdn.0b013e3182274a98 · Cited by 578
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Blanpain, C., & Fuchs, E. (2014) · Science · doi:10.1126/science.1242281 · Cited by 589
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Mascré, G., Dekoninck, S., Drogat, B., Youssef, K. K., Brohée, S., Sotiropoulou, P. A., Simons, B. D., & Blanpain, C. (2012) · Nature · doi:10.1038/nature11393 · Cited by 586
Morris, R. J., Bortner, C. D., Cotsarelis, G., Reece, J. M., Trempus, C. S., Faircloth, R. S., & Tennant, R. W. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12088.x · Cited by 567
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Growth and Regeneration of Adult β Cells Does Not Involve Specialized Progenitors
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Cotsarelis, G. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700376 · Cited by 554
Self-citationHuman Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia
Egawa, N., Egawa, K., Griffin, H. M., & Doorbar, J. (2015) · Viruses · doi:10.3390/v7072802 · Cited by 585
Lyle, S. R., Christofidou‐Solomidou, M., Liu, Y., Elder, D. E., Albelda, S., & Cotsarelis, G. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.21.3179 · Cited by 538
Self-citationLocation of stem cells of human hair follicles by clonal analysis
Rochat, A., Kobayashi, K., & Barrandon, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90383-2 · Cited by 532
Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis
Jensen, K. B., Collins, C. A., Nascimento, E. M., Tan, D. W., Frye, M., Itami, S., & Watt, F. M. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.04.014 · Cited by 523
Stem cells of the skin epithelium
Alonso, L. C., & Fuchs, E. V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734203100 · Cited by 531
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Welm, B. E., Tepera, S. B., Bowman, T. V., Graubert, T. A., Rosen, J. M., & Goodell, M. A. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0625 · Cited by 521
Harada, H., Kettunen, P. J., Jung, H.-S., Mustonen, T., Wang, Y., & Thesleff, I. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.105 · Cited by 520
Hair follicle stem cells are specified and function in early skin morphogenesis
Nowak, J. A., Polak, L., Pasolli, H. A., & Fuchs, E. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.05.009 · Cited by 554
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Oatley, J. M., & Brinster, R. L. (2012) · Physiological Reviews · doi:10.1152/physrev.00025.2011 · Cited by 531
Fehrer, C., Brunauer, R., Laschober, G. T., Unterluggauer, H., Reitinger, S., Kloss, F. R., Gülly, C., Gassner, R. J., & Lepperdinger, G. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00336.x · Cited by 498
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Chiang, C. C., Swan, R. Z., Grachtchouk, M. A., Bolinger, M., Litingtung, Y., Robertson, E. K., Cooper, M. K., Gaffield, W., Westphal, H., Beachy, P. A., et al. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9103 · Cited by 497
Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues
Simons, B. D., & Clevers, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.033 · Cited by 489
Reddy, S., Andl, T., Bagasra, A., Lu, M. M., Epstein, D. J., Morrisey, E. E., & Millar, S. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00452-x · Cited by 489
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Pelengaris, S., Littlewood, T. D., Khan, M., Elia, G., & Evan, G. I. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80350-0 · Cited by 469
van der Veen, C., Handjiski, B., Paus, R., Müller-Röver, S., Maurer, M., Eichmüller, S., Ling, G., Hofmann, U., Foitzik, K., & Mecklenburg, L. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00740.x · Cited by 553
Brownell, I., Guevara, E., Bai, C. B., Loomis, C. A., & Joyner, A. L. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.02.021 · Cited by 451
Sano, S., Itami, S., Takeda, K., Tarutani, M., Yamaguchi, Y., Miura, H., Yoshikawa, K., Akira, S., & Takeda, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4657 · Cited by 519
Role of Hormones in Pilosebaceous Unit Development
Deplewski, D., & Rosenfield, R. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.4.0404 · Cited by 443
Michel, M., Torok, N. J., Godbout, M.-J., Lussier, M., Gaudreau, P., Royal, A., & Germain, L. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.5.1017 · Cited by 441
Schallreuter, K. U., Moore, J., Wood, J. M., Beazley, W. D., Gaze, D. C., Tobin, D. J., Marshall, H. S., Panske, A., Panzig, E., & Hibberts, N. A. (1999) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/sj.jidsp.5640189 · Cited by 440
Joost, S., Zeisel, A., Jacob, T., Sun, X., La Manno, G., Lönnerberg, P., Linnarsson, S., & Kasper, M. (2016) · Cell Systems · doi:10.1016/j.cels.2016.08.010 · Cited by 429
Skin stem cells: rising to the surface
Fuchs, E. V. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708185 · Cited by 450
Vidal, V., Chaboissier, M., Lützkendorf, S., Cotsarelis, G., Mill, P., Hui, C., Ortonne, N., Ortonne, J. P., & Schedl, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.06.064 · Cited by 427
Self-citationConditional telomerase induction causes proliferation of hair follicle stem cells
Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., Wang, E., Artandi, M. K., Oro, A. E., & Artandi, S. E. (2005) · Nature · doi:10.1038/nature03836 · Cited by 425
Braun, K. M., Niemann, C., Jensen, U. B., Sundberg, J. P., Silva-Vargas, V., & Watt, F. M. (2003) · Development · doi:10.1242/dev.00703 · Cited by 425
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Rendl, M., Polak, L., & Fuchs, E. V. (2008) · Genes & Development · doi:10.1101/gad.1614408 · Cited by 430
Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Matsumura, H., Mohri, Y., Binh, N. T., Morinaga, H., Fukuda, M., Ito, M., Kurata, S., Hoeijmakers, J., & Nishimura, E. K. (2016) · Science · doi:10.1126/science.aad4395 · Cited by 416
Biology of basal cell carcinoma (Part I)
Miller, S. J. (1991) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(91)70001-i · Cited by 417
Distinct Stem Cell Populations Regenerate the Follicle and Interfollicular Epidermis
Levy, V., Lindon, C., Harfe, B. D., & Morgan, B. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.11.003 · Cited by 419
Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU
Kiel, M. J., He, S., Ashkenazi, R., Gentry, S. N., Teta, M., Kushner, J. A., Jackson, T. L., & Morrison, S. J. (2007) · Nature · doi:10.1038/nature06115 · Cited by 417
Strategies of epithelial repair: Modulation of stem cell and transit amplifying cell proliferation
Lehrer, M. S., Sun, T., & Lavker, R. M. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.19.2867 · Cited by 415
Self-citationCurrent View: Intestinal Stem Cells and Signaling
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Metadata
- Authors
- Cotsarelis, G., Sun, T.-T., & Lavker, R. M.
- Affiliations
- University of Pennsylvania (US)
- New York University (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1990-06
- Volume
- 61
- Issue
- 7
- Pages
- 1329-1337
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1980332250
- Cited by
- 2,276
- References
- 84
- Citations by year
- 2026: 22 · 2025: 23 · 2024: 39 · 2023: 35 · 2022: 48 · 2021: 57 · 2020: 68 · 2019: 65 · 2018: 59 · 2017: 69 · 2016: 60 · 2015: 75 · 2014: 91 · 2013: 102 · 2012: 120
- FWCI
- 56.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ar034511-08, 5p01ar039674-05)
- National Eye Institute (EY 06769)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 39674, AR34511)
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
- Keywords
- label-retaining cells, hair follicle bulge, hair follicle stem cells, pilosebaceous unit, outer root sheath, arrector pili muscle, hair cycle, skin carcinogenesis, keratinocyte proliferation
- MeSH terms
- Animals, Animals, Newborn, Cell Cycle, Cell Division, Cells, Cultured, Hair, Mice, Inbred Strains, Microscopy, Electron, Skin Neoplasms, Tetradecanoylphorbol Acetate, Thymidine, Mice
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