Cited by 361Genomics and Chromatin DynamicsRNA Research and SplicingNuclear Structure and Function

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Progression of the cell cycle through mitosis leads to abortion of nascent transcripts

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Shermoen, Antony W., O'Farrell, Patrick H.·1991·Cell

DOI 10.1016/0092-8674(91)90182-xPMC PMC2755073

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Abstract

Nascent transcripts of the Drosophila Ubx gene were detected by in situ hybridization. Following onset of expression, the progress of RNA polymerase (1.4 kb/min) across the gene was visualized as the successive appearance of hybridization signals from different positions within the transcription unit. Nascent transcripts disappeared at mitosis. Hybridization signals reappeared in the next cell cycle first with a 5' probe, and later, following a delay consistent with the transcription rate, with a 3' probe. Nascent transcripts were observed continuously in expressing cells of a mutant embryo in which cells are blocked in interphase. We conclude that progression through mitosis causes abortion of nascent transcripts and suggest that periodic abortion of transcription contributes to regulation of expression of large genes.

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Authors: Shermoen, A. W., & O'Farrell, P. H.
Affiliations: University of California, San Francisco (US)
Venue: Cell
Publisher: Elsevier BV
Published: 1991-10-18
Volume: 67
Issue: 2
Pages: 303-310
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(91)90182-x
PMC: PMC2755073
OpenAlex: W1984688123
Cited by: 360
References: 32
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 11 · 2022: 13 · 2021: 10 · 2020: 15 · 2019: 14 · 2018: 9 · 2017: 8 · 2016: 12 · 2015: 9 · 2014: 14 · 2013: 17 · 2012: 8
FWCI: 7.01
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: McKnight Foundation
National Institutes of Health (5p01hl043821-07)
National Heart, Lung, and Blood Institute (P0 1 HL 43821)
National Institute of General Medical Sciences (R01 GM37193, R01GM037193)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: nascent RNA, mitosis, cell cycle, RNA polymerase, Drosophila, transcriptional regulation, gene expression regulation
MeSH terms: Alkaline Phosphatase, Animals, Cell Nucleus, Digoxigenin, Drosophila melanogaster, Gene Expression Regulation, Genes, Homeobox, Mitosis, Mutation, Nucleic Acid Hybridization, Transcription, Genetic, DNA Probes

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Progression of the cell cycle through mitosis leads to abortion of nascent transcripts

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