The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid
Open accessAbstract
Exposure of murine embryos to teratogenic doses of retinoic acid (RA) induced homeotic transformations of vertebrae. Posterior transformations occurred along the complete body axis after RA administration on day 7 of gestation and were accompanied by anterior shifts of Hox gene expression domains in embryos. Anterior transformations of vertebrae in the caudal half of the vertebral column were induced on day 8.5. We suggest that the identity of a vertebral segment is specified by a combination of functionally active Hox genes, a "Hox code." In this concept the sequential activation of Hox genes defines sequentially more posterior axial levels, while mesodermal cells leave the primitive streak. Exogenous RA interferes with the normal establishment of Hox codes and thus with axial specification.
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Cited by
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Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila
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“5 rat), produces anterior transformations starting at vertebrae 15 (thoracic vertebra 8, T8) whereas excess RA at even later times, yields both rostral posteriorizing and caudal anteriorizations [223,224].”
BackgroundDevelopmental regulation of the Hox genes during axial morphogenesis in the mouse
Deschamps, J., & van Nes, J. (2005) · Development · doi:10.1242/dev.01897 · Cited by 375
Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development
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Retinoic acid synthesis and functions in early embryonic development
Kin Ting Kam, R., Deng, Y., Chen, Y., & Zhao, H. (2012) · Cell & Bioscience · doi:10.1186/2045-3701-2-11 · Cited by 283
Hox genes specify vertebral types in the presomitic mesoderm
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PARALOGOUS HOX GENES: Function and Regulation
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Chapter 9 Hox Genes and Vertebrate Axial Pattern
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Chapter 8 Hox Genes and Segmentation of the Vertebrate Hindbrain
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Gsh ‐ 1 : A novel murine homeobox gene expressed in the central nervous system
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Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle
Bäumer, N., Marquardt, T., Stoykova, A., Ashery-Padan, R., Chowdhury, K., & Gruss, P. (2002) · Development · doi:10.1242/dev.129.19.4535 · Cited by 78
Self-citationPruett, N. D., Hajdu, Z., Zhang, J., Visconti, R. P., Kern, M. J., Wellik, D. M., Majesky, M. W., & Awgulewitsch, A. (2012) · Biology Open · doi:10.1242/bio.2012039 · Cited by 26
Metadata
- Authors
- Kessel, M., & Gruss, P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1991-10
- Volume
- 67
- Issue
- 1
- Pages
- 89-104
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2013126973
- Cited by
- 1,009
- References
- 1
- FWCI
- 23.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
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