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Cited by 327Developmental Biology and Gene RegulationCellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

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The drosophila gastrulation gene concertina encodes a Gα-like protein

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Parks, Suki, Wieschaus, Eric·1991·Cell
DOI 10.1016/0092-8674(91)90652-f
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Abstract

Gastrulation is a complex process requiring the coordination of cell shape changes and cell movements. In Drosophila, gastrulation begins immediately upon cellularization of the blastoderm stage embryo with the formation of the ventral furrow and posterior midgut. Cells that form both of these invaginations change their shape via apical constriction. Embryos from mothers homozygous for mutations in the concertina (cta) gene begin furrow formation by forming a zone of tightly apposed cells, constrict some cells, and then fail to constrict enough cells to form an organized groove. The cta gene has been cloned, and sequence analysis suggests that it encodes an alpha subunit of a G protein. G proteins have a role in cell-cell communication as mediators of signals between membrane-bound receptors and intracellular effectors. The phenotype of embryos from homozygous cta mothers suggests that the cta gene plays a role in a signal transduction pathway used during gastrulation.

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Research works printed but not linked: 71

  1. Akam, 1987, The molecular basis for metameric pattern in the Drosophila embryo, Development, 101, 1, 10.1242/dev.101.1.1 · DOI
  2. Anderson, 1985, Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product, Cell, 42, 779, 10.1016/0092-8674(85)90274-0 · DOI · Paper page
  3. Baker, 1967, Cytoplasmic filaments and morphogenetic movement in the amphibian neural tube, Dev. Biol., 15, 432, 10.1016/0012-1606(67)90036-X · DOI
  4. Bender, 1983, Molecular genetics of the bithorax complex in Drosophila melanogaster, Science, 221, 23, 10.1126/science.221.4605.23 · DOI
  5. Benton, 1977, Screening λgt recombinant clones by hybridization to single plaques in situ, Science, 196, 180, 10.1126/science.322279 · DOI
  6. Beriot, 1987, Chemo-attractant-elicited increases in Dictyostelium myosin phosphorylation are due to changes in myosin localization and increases in kinase activity, J. Biol. Chem., 262, 3918, 10.1016/S0021-9258(18)61444-9 · DOI
  7. Bonner, 1976, Ecdysone-stimulated RNA synthesis in imaginal discs of Drosophila melanogaster, Chromosoma, 58, 87, 10.1007/BF00293443 · DOI
  8. Burnside, 1971, Microtubule and microfilaments in early amphibian neurulation, Dev. Biol., 26, 416, 10.1016/0012-1606(71)90073-X · DOI
  9. Carlson, 1986, Fractionation of the β subunit common to guanine nucleotide regulatory proteins with the cytoskeleton, Mol. Pharmacol., 30, 463, 10.1016/S0026-895X(25)10394-5 · DOI
  10. de Sousa, 1989, The Drosophila Goα-like G protein gene produces multiple transcripts and is expressed in the nervous system and ovaries, J. Biol. Chem., 264, 18544, 10.1016/S0021-9258(18)51502-7 · DOI
  11. Devereux, 1984, A comprehensive set of sequence analysis programs for the VAX, Nucl. Acids Res., 12, 387, 10.1093/nar/12.1Part1.387 · DOI
  12. Doyle, 1986, Transcripts encoded by a homeobox gene are restricted to dorsal tissues of Drosophila embryos, Nature, 323, 76, 10.1038/323076a0 · DOI
  13. Ettensohn, 1985, Mechanisms of epithelial invaginations, Quart. Rev. Biol., 60, 289, 10.1086/414426 · DOI
  14. Feinberg, 1983, A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity, Anal. Biochem., 132, 6, 10.1016/0003-2697(83)90418-9 · DOI
  15. Firtel, 1989, G protein linked signal transduction pathways in development: Dictyostelium as an experimental system, Cell, 58, 235, 10.1016/0092-8674(89)90837-4 · DOI
  16. Frischauf, 1983, Lambda replacement vectors carrying polylinker sequences, J. Mol. Biol., 170, 827, 10.1016/S0022-2836(83)80190-9 · DOI
  17. Frohnhofer, 1986, Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid, Nature, 324, 120, 10.1038/324120a0 · DOI
  18. Gilman, 1987, G proteins: transducers of receptor-generated signals, Annu. Rev. Biochem., 56, 615, 10.1146/annurev.bi.56.070187.003151 · DOI
  19. Gribskov, 1986, Sigma factors from E. coli, B. subtilis, phage SPO1, and phage T4 are homologous proteins, Nucl. Acids Res., 14, 6745, 10.1093/nar/14.16.6745 · DOI
  20. Gustafson, 1962, Cellular mechanisms in the morphogenesis of the sea urchin larva. Changes in shape of cell sheets, Exp. Cell Res., 27, 260, 10.1016/0014-4827(62)90229-X · DOI
  21. Hall, 1989, Transduction of the chemotactic signal to the actin cytoskeleton of Dictyostelium discoideum, Dev. Biol., 136, 517, 10.1016/0012-1606(89)90277-7 · DOI
  22. Halliday, 1984, Regional homology in GTP binding proto-oncogene products and elongation factors, J. Cyclic Nucl. Res., 9, 435
  23. Higuchi, 1989, Production of single stranded DNA templates by exonuclease digestion following the polymerase chain reaction, Nucl. Acids Res., 17, 5865, 10.1093/nar/17.14.5865 · DOI
  24. Hiromi, 1985, Control elements of the Drosophila segmentation gene fushi tarazu, Cell, 43, 603, 10.1016/0092-8674(85)90232-6 · DOI
  25. Kalfayan, 1981, α-Tubulin genes of Drosophila, Cell, 24, 97, 10.1016/0092-8674(81)90505-5 · DOI
  26. Kanaho, 1984, Rhodopsin-enhanced GTPase activity of the inhibitory GTP binding protein of adenylate cyclase, J. Biol. Chem., 259, 7378, 10.1016/S0021-9258(17)42799-2 · DOI
  27. Kreitman, 1989, A strategy for producing single-stranded DNA in the polymerase chain reaction: a direct method for genomic sequencing, Gene Anal. Tech., 6, 84, 10.1016/0735-0651(89)90021-6 · DOI
  28. Leptin, 1990, Cell shape changes during gastrulation in Drosophila, Development, 110, 73, 10.1242/dev.110.1.73 · DOI
  29. Liu, 1988, Evidence that cyclic GMP regulates myosin interaction with the cytoskeleton during chemotaxis of Dictyostelium, J. Cell Sci., 90, 123, 10.1242/jcs.90.1.123 · DOI
  30. Lochrie, 1988, G protein multiplicity in eucaryotic signal transduction systems, Biochemistry, 27, 4957, 10.1021/bi00414a001 · DOI
  31. MacDonald, 1986, A molecular gradient in early Drosophila embryos and its role in specifying body pattern, Nature, 324, 537, 10.1038/324537a0 · DOI
  32. Mattera, 1988, Individual splice variants of the α subunit of the G protein Gs activate both adenylate cyclase and Ca+2 channels, Science, 243, 804, 10.1126/science.2536957 · DOI
  33. Nachimias, 1989, Chemoattractant elicited translocation of myosin in motile Dictyostelium, Cell Motil. Cytoskel., 13, 158, 10.1002/cm.970130304 · DOI
  34. Nardi, 1976, The differential adhesion model gradient of a non-diffusible cell surface parameter, J. Embryol. Exp. Morohol., 36, 489
  35. Nüsslein-Volhard, 1979, Maternal effect mutations that alter the spatial coordinates of the embryo of Drosophila melanogaster, Symp. Soc. Dev. Biol., 37, 185
  36. Nüsslein-Volhard, 1987, Determination of anteroposterior polarity in Drosophila, Science, 238, 1675, 10.1126/science.3686007 · DOI
  37. Odell, 1981, The mechanical basis of morphogenesis. I. Epithelial folding and invagination, Dev. Biol., 85, 446, 10.1016/0012-1606(81)90276-1 · DOI
  38. Parks, 1986, Replication and expression of an X linked cluster of Drosophila chorion genes, Dev. Biol., 117, 294, 10.1016/0012-1606(86)90372-6 · DOI
  39. Pearson, 1988, Improved tools for biological sequence comparison, 85, 2444
  40. Perrimon, 1989, Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on the X chromosome, Genetics, 121, 333, 10.1093/genetics/121.2.333 · DOI
  41. Provost, 1988, A Drosophila melanogaster G protein α subunit gene is expressed primarily in embryos and pupae, J. Biol. Chem., 263, 12070, 10.1016/S0021-9258(18)37894-3 · DOI
  42. Reed, 1989, Golf: an olfactory neuron specific G protein involved in odorant signal transduction, Science, 244, 790, 10.1126/science.2499043 · DOI
  43. Roth, 1989, A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo, Cell, 59, 1189, 10.1016/0092-8674(89)90774-5 · DOI
  44. Schatz, 1986, Genetically essential and nonessential α tubulin genes specify functionally interchangeable proteins, Mol. Cell. Biol., 6, 3722
  45. Schmidt, 1989, Neuronal expression of a newly identified Drosophila melanogaster G protein αo subunit, Cell Regul., 1, 125, 10.1091/mbc.1.1.125 · DOI
  46. Schoenwolf, 1984, Quantitative analyses of changes in cell shapes during bending of the avian neural plate, Dev. Biol., 105, 257, 10.1016/0012-1606(84)90284-7 · DOI
  47. Schoenwolf, 1990, Mechanisms of neurulation: traditional viewpoint and recent advances, Development, 109, 243, 10.1242/dev.109.2.243 · DOI
  48. Schüpbach, 1986, Maternal-effect mutations altering the anterior-posterior pattern of the Drosophila embryo, Roux's Arch. Dev. Biol., 195, 302, 10.1007/BF00376063 · DOI
  49. Schüpbach, 1989, Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations, Genetics, 121, 101, 10.1093/genetics/121.1.101 · DOI
  50. Simpson, 1983, Maternal-zygotic gene interactions during formation of the dorsoventral pattern in Drosophila embryos, Genetics, 105, 615, 10.1093/genetics/105.3.615 · DOI · Paper page
  51. Southern, 1975, Detection of specific sequences among DNA framents separated by gel electrophoresis, J. Mol. Biol., 98, 504, 10.1016/S0022-2836(75)80083-0 · DOI
  52. Staden, 1980, Automation of the computer handling of gel reading data produced by the shotgun method of DNA sequencing, Nucl. Acids Res., 8, 3673, 10.1093/nar/8.16.3673 · DOI
  53. Stryer, 1986, Cyclic GMP cascade of vision, Annu. Rev. Neurosci., 9, 87, 10.1146/annurev.ne.09.030186.000511 · DOI
  54. Stryer, 1986, G proteins: a family of signal transducers, Annu. Rev. Cell Biol., 2, 391, 10.1146/annurev.cb.02.110186.002135 · DOI
  55. Suter, 1989, Bicaudal-D, a Drosophila gene involved in developmental asymmetry: localized transcript accumulation in ovaries and sequence similarity to myosin heavy chain tail domains, Genes Dev., 3, 1957, 10.1101/gad.3.12a.1957 · DOI
  56. Tatchell, 1984, Requirement of either of a pair of ras re;ated genes of Saccharomyces cerevisiae for spore viability, Nature, 309, 523, 10.1038/309523a0 · DOI
  57. Tautz, 1989, A non-radioactive in situ hybridization method for the localization of specific RNAs in the Drosophila embryos reveals translational control of the segmentation gene hunchback, Chromosoma, 98, 81, 10.1007/BF00291041 · DOI
  58. Thambi, 1989, Immunological and molecular characterization of Goα-like proteins in the Drosophila central nervous system, J. Biol. Chem., 264, 18552, 10.1016/S0021-9258(18)51503-9 · DOI
  59. Thisse, 1988, Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos, EMBO J., 7, 2175, 10.1002/j.1460-2075.1988.tb03056.x · DOI
  60. Tobin, 1980, Multiple actin-related sequences in the Drosophila melanogaster genome, Cell, 19, 121, 10.1016/0092-8674(80)90393-1 · DOI
  61. Turner, 1977, Scanning electron microscopy of Drosophila melanogaster embryogenesis. II. Gastrulation and segmentation, Dev. Biol., 57, 403, 10.1016/0012-1606(77)90225-1 · DOI
  62. VanDongen, 1988, Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go, Science, 242, 1433, 10.1126/science.3144040 · DOI
  63. Wakimoto, 1990, The effects of chromosome rearrangements on the expression of heterochromatic genes in chromosome 2L of Drosophila melanogaster, Genetics, 125, 141, 10.1093/genetics/125.1.141 · DOI
  64. Whiteway, 1989, The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein, Cell, 56, 467, 10.1016/0092-8674(89)90249-3 · DOI
  65. Wieschaus, 1988, Requirements for X-linked zygotic gene activity during cellularization of early Drosophila embryos, Development, 104, 483, 10.1242/dev.104.3.483 · DOI
  66. Wieschaus, 1984, Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. III. Zygotic loci on the X chromosome and fourth chromosome, Roux's Arch. Dev. Biol., 193, 296, 10.1007/BF00848158 · DOI
  67. Yatani, 1988, The G protein gatedatrial K+ channel is stimulated by three distinct Giα-subunits, Nature, 336, 680, 10.1038/336680a0 · DOI
  68. Yoon, 1989, Molecular characterization of Drosophila gene encoding Go α subunit homolog, J. Biol. Chem., 264, 18536, 10.1016/S0021-9258(18)51501-5 · DOI
  69. Zwaan, 1973, Changes in cell and organ shape during early development of the ocular lens, Am. Zool., 13, 1039, 10.1093/icb/13.4.1039 · DOI
  70. Zwaan, 1971, Cell population kinetics in the chicken lens primordium during and shortly after its contact with the optic cup, Dev. Biol., 25, 96, 10.1016/0012-1606(71)90021-2 · DOI
  71. Zusman, 1985, Requirements for zygotic gene activity during gastrulation in Drosophila melanogaster, Dev. Biol., 111, 359, 10.1016/0012-1606(85)90490-7 · DOI

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Metadata

Authors
Parks, S., & Wieschaus, E.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Princeton University (US)
ORCID
Wieschaus, Eric
Venue
Cell
Publisher
Elsevier BV
Published
1991-01
Volume
64
Issue
2
Pages
447-458
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/0092-8674(91)90652-f
OpenAlex
W1969714257
Cited by
327
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 10 · 2023: 10 · 2022: 9 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 4 · 2017: 12 · 2016: 10 · 2015: 4 · 2014: 10 · 2013: 11 · 2012: 5
FWCI
5.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (5R37 HD 15587)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
G protein alpha subunit, Drosophila gastrulation, ventral furrow formation, apical constriction, signal transduction, intercellular communication, gene cloning
MeSH terms
Amino Acid Sequence, Animals, Base Sequence, DNA, Drosophila, Embryo, Nonmammalian, Female, Gastrula, Gene Expression Regulation, Microscopy, Electron, Scanning, Molecular Sequence Data, Mutation, Sequence Homology, Nucleic Acid, GTP-Binding Proteins

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