Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product
Abstract
Within the group of maternal effect genes necessary for the establishment of the dorsal-ventral pattern of the Drosophila embryo, the Toll gene mutates to give a singular variety of embryonic phenotypes. Lack of function alleles produce dorsalized embryos as a recessive maternal effect. Dominant gain of function alleles result in ventralized embryos. Other recessive alleles cause partial dorsalization or lateralization of the embryonic pattern. Gene dosage studies indicate that the dominant ventralized phenotype results from an altered activity of the Toll product. Complementation studies show specific trans interactions between copies of the Toll product. Double mutant phenotypes suggest that the products of several other dorsal-group genes regulate the activity of Toll.
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Different levels of activated Toll direct graded Dorsal-dependent gene expression outputs.
“Different levels of activated Toll direct graded Dorsal-dependent gene expression outputs.”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Anderson et al. 1985
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- Authors
- Anderson, K. V., Jürgens, G., & Nüsslein-Volhard, C.
- Affiliations
- Friedrich Miescher Laboratory (DE)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1985-10
- Volume
- 42
- Issue
- 3
- Pages
- 779-789
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2133616332
- Cited by
- 691
- References
- 0
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 19 · 2023: 21 · 2022: 25 · 2021: 24 · 2020: 21 · 2019: 13 · 2018: 30 · 2017: 24 · 2016: 21 · 2015: 17 · 2014: 34 · 2013: 29 · 2012: 30
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- dorsal-ventral polarity, Drosophila embryo, maternal effect genes, dorsalization, ventralization, gene dosage, embryonic patterning
- MeSH terms
- Alleles, Animals, Drosophila melanogaster, Embryo, Nonmammalian, Female, Genes, Dominant, Genes, Recessive, Heterozygote, Male, Mitosis, Mutation, Phenotype
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