Regulation, signaling, and physiological functions of G-Proteins

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

Gilman, A. G. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.003151 · Cited by 6,405 · see citing works

Crystal structure of the β2 adrenergic receptor–Gs protein complex

Rasmussen, S. G. F., DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., et al. (2011) · Nature · doi:10.1038/nature10361 · Cited by 3,009 · see citing works

Seven-transmembrane receptors

Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,712 · see citing works

The structure and function of G-protein-coupled receptors

Rosenbaum, D. M., Rasmussen, S. G. F., & Kobilka, B. K. (2009) · Nature · doi:10.1038/nature08144 · Cited by 2,534 · see citing works

The GTPase superfamily: a conserved switch for diverse cell functions

Bourne, H. R., Sanders, D. A. R., & McCormick, F. P. (1990) · Nature · doi:10.1038/348125a0 · Cited by 2,336 · see citing works

Diversity of G Proteins in Signal Transduction

Simon, M. I., Strathmann, M., & Gautam, N. (1991) · Science · doi:10.1126/science.1902986 · Cited by 2,016 · see citing works

The Guanine Nucleotide-Binding Switch in Three Dimensions

Vetter, I. R., & Wittinghofer, A. (2001) · Science · doi:10.1126/science.1062023 · Cited by 1,875 · see citing works

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

Wu, B., Chien, E. Y. T., Mol, C. D., Fenalti, G., Liu, W., Katritch, V., Abagyan, R. A., Brooun, A., Wells, P. G., Bi, F. C., et al. (2010) · Science · doi:10.1126/science.1194396 · Cited by 1,785 · see citing works

Regulation of Phosphoinositide-Specific Phospholipase C

Rhee, S. G. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.281 · Cited by 1,628 · see citing works

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

Prenzel, N., Zwick, E., Daub, H., Leserer, M., Abraham, R., Wallasch, C., & Ullrich, A. (1999) · Nature · doi:10.1038/47260 · Cited by 1,507 · see citing works

Molecular signatures of G-protein-coupled receptors

Venkatakrishnan, A., Deupí, X., Lebon, G., Tate, C. G., Schertler, G. F. X., & Babu, M. M. (2013) · Nature · doi:10.1038/nature11896 · Cited by 1,502 · see citing works

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

Daub, H., Weiß, F. U., Wallasch, C., & Ullrich, A. (1996) · Nature · doi:10.1038/379557a0 · Cited by 1,476 · see citing works

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

Manglik, A., Kruse, A. C., Kobilka, T. S., Thian, F. S., Mathiesen, J. M., Sunahara, R. K., Pardo, L., Weis, W. I., Kobilka, B. K., & Granier, S. (2012) · Nature · doi:10.1038/nature10954 · Cited by 1,362 · see citing works

Heterotrimeric G protein activation by G-protein-coupled receptors

Oldham, W. M., & Hamm, H. E. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2299 · Cited by 1,184 · see citing works

Mammalian G Proteins and Their Cell Type Specific Functions

Wettschureck, N., & Offermanns, S. (2005) · Physiological Reviews · doi:10.1152/physrev.00003.2005 · Cited by 1,161 · see citing works

G PROTEIN MECHANISMS: Insights from Structural Analysis

Sprang, S. R. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.639 · Cited by 1,066 · see citing works

Crystal structure of opsin in its G-protein-interacting conformation

Scheerer, P., Park, J. H., Hildebrand, P. W., Kim, Y. J., Krauß, N., Choe, H.-W., Hofmann, K. P., & Ernst, O. P. (2008) · Nature · doi:10.1038/nature07330 · Cited by 1,059 · see citing works

Structure-Function of the G Protein–Coupled Receptor Superfamily

Katritch, V., Cherezov, V., & Stevens, R. C. (2012) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-032112-135923 · Cited by 1,051 · see citing works

Crystal structure of the ligand-free G-protein-coupled receptor opsin

Park, J. H., Scheerer, P., Hofmann, K. P., Choe, H., & Ernst, O. P. (2008) · Nature · doi:10.1038/nature07063 · Cited by 903 · see citing works

Structure of the human κ-opioid receptor in complex with JDTic

Wu, H., Wacker, D., Mileni, M., Katritch, V., Han, G. W., Vardy, E., Liu, W., Thompson, A. A., Huang, X., Carroll, F. I., et al. (2012) · Nature · doi:10.1038/nature10939 · Cited by 885 · see citing works

Regulation of Phosphoinositide-specific Phospholipase C Isozymes

Rhee, S. G., & Bae, Y. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15045 · Cited by 876 · see citing works

p115 RhoGEF, a GTPase Activating Protein for Gα 12 and Gα 13

Kozasa, T., Jiang, X., Hart, M. J., Sternweis, P. M., Singer, W. D., Gilman, A. G., Bollag, G., & Sternweis, P. C. (1998) · Science · doi:10.1126/science.280.5372.2109 · Cited by 855 · see citing works

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

Coleman, D. E., Berghuis, A. M., Lee, E., Linder, M., Gilman, A. G., & Sprang (1994) · Science · doi:10.1126/science.8073283 · Cited by 827 · see citing works

The 2.2 Å crystal structure of transducin-α complexed with GTPγS

Noel, J. P., Hamm, H. E., & Sigler, P. B. (1993) · Nature · doi:10.1038/366654a0 · Cited by 803 · see citing works

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

Tesmer, J. J. G., Berman, D. M., Gilman, A. G., & Sprang, S. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80204-4 · Cited by 779 · see citing works

What Is the Role of β-Adrenergic Signaling in Heart Failure?

Lohse, M. J., Engelhardt, S. H., & Thomas Eschenhagen, A. (2003) · Circulation Research · doi:10.1161/01.res.0000102042.83024.ca · Cited by 766 · see citing works

The PAR-aPKC system: lessons in polarity

Suzuki, A., & Ohno, S. (2006) · Journal of Cell Science · doi:10.1242/jcs.02898 · Cited by 695 · see citing works

Oligomerization of G-protein-coupled transmitter receptors

Bouvier, M. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067575 · Cited by 668 · see citing works

G‐protein‐coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G‐protein recognition

Wess, J. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.5.9141501 · Cited by 596 · see citing works

Foot and mouth: podosomes, invadopodia and circular dorsal ruffles

Buccione, R., Orth, J. D., & McNiven, M. A. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1436 · Cited by 594 · see citing works

Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function

Angers, S., Salahpour, A., & Bouvier, M. (2002) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.091701.082314 · Cited by 587 · see citing works

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

Watson, N., Linder, M. E., Druey, K. M., Kehrl, J. H., & Blumer, K. (1996) · Nature · doi:10.1038/383172a0 · Cited by 546 · see citing works

Spindle orientation during asymmetric cell division

Siller, K. H., & Doe, C. Q. (2009) · Nature Cell Biology · doi:10.1038/ncb0409-365 · Cited by 474 · see citing works

Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

Salom, D., Lodowski, D. T., Stenkamp, R. E., Trong, I. L., Golczak, M., Jastrzebska, B., Harris, T., Ballesteros, J. A., & Palczewski, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608022103 · Cited by 442 · see citing works

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

Hobson, J. P., Rosenfeldt, H. M., Barak, L. S., Olivera, A., Poulton, S., Caron, M. G., Milstien, S., & Spiegel, S. (2001) · Science · doi:10.1126/science.1057559 · Cited by 426 · see citing works

Variable and tissue-specific hormone resistance in heterotrimeric G s protein α-subunit (G s α) knockout mice is due to tissue-specific imprinting of the G s α gene

Yu, S., Yu, D., Lee, E., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8715 · Cited by 409 · see citing works

Analysis of partner of inscuteable, a Novel Player of Drosophila Asymmetric Divisions, Reveals Two Distinct Steps in Inscuteable Apical Localization

Yu, F., Morin, X., Cai, Y., Yang, X., & Chia, W. N. (2000) · Cell · doi:10.1016/s0092-8674(00)80676-5 · Cited by 370 · see citing works

Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα 13 Deficiency

Offermanns, S., Mancino, V., Revel, J., & Simon, M. I. (1997) · Science · doi:10.1126/science.275.5299.533 · Cited by 336 · see citing works

Dopamine D2 receptors form higher order oligomers at physiological expression levels

Guo, W. X., Urizar, E., Králíková, M., Mobarec, J. C., Shi, L., Filizola, M., & Javitch, J. A. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.153 · Cited by 334 · see citing works

Activation of the human c‐kit product by ligand‐induced dimerization mediates circular actin reorganization and chemotaxis.

Blume‐Jensen, P., Claesson, L., Siegbahn, A. G., Zsebo, K. M., Westermark, B., & Heldin, C. H. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04989.x · Cited by 329 · see citing works

The drosophila gastrulation gene concertina encodes a Gα-like protein

Parks, S., & Wieschaus, E. (1991) · Cell · doi:10.1016/0092-8674(91)90652-f · Cited by 327 · see citing works

Heterotrimeric G Proteins Direct Two Modes of Asymmetric Cell Division in the Drosophila Nervous System

Schaefer, M., Petronczki, M. P., Dorner, D., Forte, M. A., & Knoblich, J. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00521-9 · Cited by 323 · see citing works

Differential Roles of WAVE1 and WAVE2 in Dorsal and Peripheral Ruffle Formation for Fibroblast Cell Migration

Suetsugu, S., Yamazaki, D., Kurisu, S., & Takenawa, T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00297-1 · Cited by 314 · see citing works

Mammalian Ric-8A (Synembryn) Is a Heterotrimeric Gα Protein Guanine Nucleotide Exchange Factor

Tall, G. G., Krumins, A. M., & Gilman, A. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211862200 · Cited by 313 · see citing works

A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells.

Schliwa, M., Nakamura, T., Porter, K. R., et al. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.3.1045 · Cited by 298 · see citing works

Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation

Guo, W. X., Shi, L., Filizola, M., Weinstein, H., & Javitch, J. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508950102 · Cited by 291 · see citing works

Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos

Colombo, K., Grill, S. W., Kimple, R. J., Willard, F. S., Siderovski, D. P., & Gönczy, P. (2003) · Science · doi:10.1126/science.1084146 · Cited by 285 · see citing works

Receptor-independent Activators of Heterotrimeric G-protein Signaling Pathways

Takesono, A., Cismowski, M. J., Ribas, C., Bernard, M., Chung, P., Hazard, S., Duzic, E., & Lanier, S. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33202 · Cited by 274 · see citing works

Distinct roles for Gα and Gβγ in regulating spindle position and orientation in Caenorhabditis elegans embryos

Gotta, M., & Ahringer, J. (2001) · Nature Cell Biology · doi:10.1038/35060092 · Cited by 264 · see citing works

G13 is an essential mediator of platelet activation in hemostasis and thrombosis

Moers, A., Nieswandt, B., Maßberg, S., Wettschureck, N., Grüner, S., Konrad, I., Schulte, V., Aktas, B., Gratacap, M., Simon, M. I., et al. (2003) · Nature Medicine · doi:10.1038/nm943 · Cited by 264 · see citing works

Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state

Huang, J., Chen, S., Zhang, J. J., & Huang, X. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2504 · Cited by 261 · see citing works

G Protein Subunit Gα 13 Binds to Integrin α IIb β 3 and Mediates Integrin “Outside-In” Signaling

Gong, H., Shen, B., Flevaris, P., Chow, C. R., Lam, S. C.-T., Voyno-Yasenetskaya, T., Kozasa, T., & Du, X. (2010) · Science · doi:10.1126/science.1174779 · Cited by 256 · see citing works

Structural determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits

Kimple, R. J., Kimple, M. E., Betts, L., Sondek, J., & Siderovski, D. P. (2002) · Nature · doi:10.1038/416878a · Cited by 243 · see citing works

The Expanding Roles of Gβγ Subunits in G Protein–Coupled Receptor Signaling and Drug Action

Khan, S. M., Sleno, R., Gora, S., Zylbergold, P., Laverdure, J., Labbé, J.-C., Miller, G. J., & Hébert, T. E. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005603 · Cited by 239 · see citing works

Asymmetrically Distributed C. elegans Homologs of AGS3/PINS Control Spindle Position in the Early Embryo

Gotta, M., Yan, D., Peterson, Y. K., Lanier, S. M., & Ahringer, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00371-3 · Cited by 239 · see citing works

Localization of p21-Activated Kinase 1 (PAK1) to Pinocytic Vesicles and Cortical Actin Structures in Stimulated Cells

Dharmawardhane, S., Sanders, L. C., Martin, S. S., et al. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.6.1265 · Cited by 232 · see citing works

A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C. elegansPreprint

Srinivasan, D. G., Fisk, R. M., Xu, H., & van den Heuvel, S. (2003) · Genes & Development · doi:10.1101/gad.1081203 · Cited by 231 · see citing works

A Dynamin–Cortactin–Arp2/3 Complex Mediates Actin Reorganization in Growth Factor-stimulated Cells

Krueger, E. W., Orth, J. D., Cao, H., & McNiven, M. A. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-08-0466 · Cited by 216 · see citing works

Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF

Suzuki, N., Nakamura, S., Mano, H., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0234057100 · Cited by 215 · see citing works

Insulin action impaired by deficiency of the G-protein subunit Giα2

Moxham, C. M., & Malbon, C. C. (1996) · Nature · doi:10.1038/379840a0 · Cited by 214 · see citing works

The Guanine Nucleotide Exchange Factor p63RhoGEF, a Specific Link between Gq/11-coupled Receptor Signaling and RhoA

Lutz, S., Blomquist, A., Yang, Y., Rümenapp, U., Jakobs, K. H., Schmidt, M., & Wieland, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411322200 · Cited by 206 · see citing works

Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling

Cismowski, M. J., Takesono, A., Ma, C., et al. (1999) · Nature Biotechnology · doi:10.1038/12867 · Cited by 202 · see citing works

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein α-subunits

Soundararajan, M., Willard, F. S., Kimple, A. J., Turnbull, A. P., Ball, L., Schoch, G., Gileadi, C., Fedorov, O., Dowler, E. F., Higman, V. A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801508105 · Cited by 201 · see citing works

G-protein diseases furnish a model for the turn-on switch

Iiri, T., Farfel, Z., & Bourne, H. R. (1998) · Nature · doi:10.1038/27831 · Cited by 195 · see citing works

RIC-8 Is Required for GPR-1/2-Dependent Gα Function during Asymmetric Division of C. elegans Embryos

Afshar, K., Willard, F. S., Colombo, K., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.026 · Cited by 191 · see citing works

Getting Membrane Flow and the Cytoskeleton to Cooperate in Moving Cells

Bretscher, M. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81380-x · Cited by 190 · see citing works

The G protein Gα12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain

Jiang, Y., Ma, W., Wan, Y., et al. (1998) · Nature · doi:10.1038/27454 · Cited by 186 · see citing works

Distribution of Protein Folds in the Three Superkingdoms of Life

Wolf, Y. I., Brenner, S. E., Bash, P. A., & Koonin, E. V. (1999) · Genome Research · doi:10.1101/gr.9.1.17 · Cited by 183 · see citing works

GIV is a nonreceptor GEF for Gαi with a unique motif that regulates Akt signaling

Garcia‐Marcos, M., Ghosh, P., & Farquhar, M. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900294106 · Cited by 174 · see citing works

Ric-8A and Giα Recruit LGN, NuMA, and Dynein to the Cell Cortex To Help Orient the Mitotic Spindle

Woodard, G. E., Huang, N., Cho, H., Miki, T., Tall, G. G., & Kehrl, J. H. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00394-10 · Cited by 170 · see citing works

Dimerization in GPCR mobility and signaling

Lohse, M. J. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.10.007 · Cited by 169 · see citing works

Crystal structure of a common GPCR-binding interface for G protein and arrestin

Szczepek, M., Beyrière, F., Hofmann, K. P., Elgeti, M., Kazmin, R., Rose, A., Bartl, F. J., von Stetten, D., Heck, M., Sommer, M. E., et al. (2014) · Nature Communications · doi:10.1038/ncomms5801 · Cited by 165 · see citing works

Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor

Mellström, K., Heldin, C., & Westermark, B. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90468-5 · Cited by 161 · see citing works

G Proteins Are Required for Spatial Orientation of Early Cell Cleavages in C. elegans Embryos

Zwaal, R. R., Ahringer, J., van Luenen, H. G. A. M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80135-x · Cited by 153 · see citing works

Tethering of the Platelet-derived Growth Factor β Receptor to G-protein-coupled Receptors

Alderton, F., Rakhit, S., Kong, K. C., Palmer, T. M., Sambi, B. S., Pyne, S., & Pyne, N. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102771200 · Cited by 152 · see citing works

G12/G13-mediated signalling in mammalian physiology and disease

Worzfeld, T., Wettschureck, N., & Offermanns, S. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.08.002 · Cited by 152 · see citing works

Paternal versus maternal transmission of a stimulatory G-protein α subunit knockout produces opposite effects on energy metabolism

Yu, S., Gavrilova, O., Chen, H., Lee, R., Liu, J., Pacák, K., Parlow, A. F., Quon, M. J., Reitman, M. L., & Weinstein, L. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8437 · Cited by 151 · see citing works

Activation of Heterotrimeric G-protein Signaling by a Ras-related Protein

Cismowski, M. J., Ma, C., Ribas, C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000322200 · Cited by 150 · see citing works

Circular ruffle formation and closure lead to macropinocytosis in hepatocyte growth factor/scatter factor-treated cells.

Dowrick, P. G., Kenworthy, P., McCann, B. M., & Warn, R. M. (1993) · PubMed · Cited by 147 · see citing works

Selective Interaction of AGS3 with G-proteins and the Influence of AGS3 on the Activation State of G-proteins

Bernard, M. L., Peterson, Y. K., Chung, P., Jourdan, J., & Lanier, S. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005291200 · Cited by 145 · see citing works

The effect of platelet-derived growth factor on morphology and motility of human glial cells

Mellstr�m, K., H�glund, A.-S., Nist�r, M., Heldin, C., Westermark, B., & Lindberg, U. (1983) · Journal of Muscle Research and Cell Motility · doi:10.1007/bf00712117 · Cited by 144 · see citing works

Signaling by the G Class of G Proteins

Dhanasekaran, N., & Dermott, J. M. (1996) · Cellular Signalling · doi:10.1016/0898-6568(96)00048-4 · Cited by 143 · see citing works

Drosophila Ric-8 regulates Gαi cortical localization to promote Gαi-dependent planar orientation of the mitotic spindle during asymmetric cell division

David, N. B., Martin, C. A., Manil-Ségalen, M., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1319 · Cited by 143 · see citing works

Most central nervous system D2 dopamine receptors are coupled to their effectors by Go

Jiang, M., Spicher, K., Boulay, G., Wang, Y., & Birnbaumer, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051632598 · Cited by 135 · see citing works

RIC-8 (Synembryn)

Miller, K. G., Emerson, M. D., McManus, J. R., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)00037-4 · Cited by 134 · see citing works

Identification and Characterization of GIV, a Novel Gαi/s -interacting Protein Found on COPI, Endoplasmic Reticulum-Golgi Transport Vesicles

Le-Niculescu, H., Niesman, I. R., Fischer, T., DeVries, L., & Farquhar, M. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501833200 · Cited by 134 · see citing works

Gα13 Stimulates Cell Migration through Cortactin-interacting Protein Hax-1

Radhika, V., Onésime, D., Ha, J. H., & Dhanasekaran, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408836200 · Cited by 134 · see citing works

Ligand sensitivity in dimeric associations of the serotonin 5HT2c receptor

Mancia, F., Assur, Z., Herman, A. G., et al. (2008) · EMBO Reports · doi:10.1038/embor.2008.27 · Cited by 132 · see citing works

Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins

Hampoelz, B., Hoeller, O., Bowman, S., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1318 · Cited by 130 · see citing works

Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins

Wang, H., Ng, K. H., Qian, H., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1317 · Cited by 129 · see citing works

A Role for RIC-8 (Synembryn) and GOA-1 (Goα) in Regulating a Subset of Centrosome Movements During Early Embryogenesis in Caenorhabditis elegans

Miller, K. G., & Rand, J. B. (2000) · Genetics · doi:10.1093/genetics/156.4.1649 · Cited by 128 · see citing works

The role of dimerisation in the cellular trafficking of G-protein-coupled receptors

Milligan, G. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.09.010 · Cited by 127 · see citing works

Sphingosine 1-Phosphate and Platelet-derived Growth Factor (PDGF) Act via PDGFβ Receptor-Sphingosine 1-Phosphate Receptor Complexes in Airway Smooth Muscle Cells

Waters, C., Sambi, B. S., Kong, K. C., Thompson, D., Pitson, S. M., Pyne, S., & Pyne, N. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208560200 · Cited by 126 · see citing works

Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release

Meigs, T. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.021350998 · Cited by 126 · see citing works

Ric-8 Proteins Are Molecular Chaperones That Direct Nascent G Protein α Subunit Membrane Association

Gabay, M., Pinter, M., Wright, F. A., Chan, P., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., & Tall, G. G. (2011) · Science Signaling · doi:10.1126/scisignal.2002223 · Cited by 123 · see citing works

Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans

Couwenbergs, C., Labbé, J., Goulding, M. Q., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200707085 · Cited by 120 · see citing works

Interaction of Gα 12 with Gα 13 and Gα q signaling pathways

Gu, J. L., Müller, S., Mancino, V., Offermanns, S., & Simon, M. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102291599 · Cited by 119 · see citing works

Receptor tyrosine kinase–G-protein-coupled receptor signalling platforms: out of the shadow?

Pyne, N. J., & Pyne, S. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.04.002 · Cited by 112 · see citing works

Ric-8B, an Olfactory Putative GTP Exchange Factor, Amplifies Signal Transduction through the Olfactory-Specific G-Protein Gαolf

Dannecker, L. E. C. V., Mercadante, A. F., & Malnic, B. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4595-04.2005 · Cited by 111 · see citing works

GPCRs and cancer

Lappano, R., & Maggiolini, M. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.183 · Cited by 110 · see citing works

RGS-7 Completes a Receptor-Independent Heterotrimeric G Protein Cycle to Asymmetrically Regulate Mitotic Spindle Positioning in C. elegans

Hess, H. A., Röper, J.-C., Grill, S. W., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.025 · Cited by 110 · see citing works

Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with Gαi2

Mochizuki, N., Cho, G., Wen, B. G., et al. (1996) · Gene · doi:10.1016/s0378-1119(96)00456-8 · Cited by 107 · see citing works

The study of G‐protein coupled receptor oligomerization with computational modeling and bioinformatics

Filizola, M., & Weinstein, H. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04730.x · Cited by 106 · see citing works

AGS3 Inhibits GDP Dissociation from Gα Subunits of the Gi Family and Rhodopsin-dependent Activation of Transducin

Natochin, M., Lester, B., Peterson, Y. K., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006478200 · Cited by 106 · see citing works

Control of Embryonic Spindle Positioning and Gα Activity by C. elegans RIC-8

Couwenbergs, C., Spilker, A. C., & Gotta, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.059 · Cited by 105 · see citing works

Functional role of protease activated receptors in vascular biology

Alberelli, M. A., & Candia, E. D. (2014) · Vascular Pharmacology · doi:10.1016/j.vph.2014.06.001 · Cited by 103 · see citing works

An obligatory requirement for the heterotrimeric G protein G i3 in the antiautophagic action of insulin in the liver

Gohla, A., Klement, K., Piekorz, R. P., Pexa, K., Dahl, S. V., Spicher, K., Dreval', V. I., Häussinger, D., Birnbaumer, L., & Nürnberg, B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611434104 · Cited by 103 · see citing works

Oligomeric forms of G protein-coupled receptors (GPCRs)

Palczewski, K. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.002 · Cited by 102 · see citing works

Structural Basis of Effector Regulation and Signal Termination in Heterotrimeric Gα Proteins

Sprang, S. R., Chen, Z., & Du, X. (2007) · Advances in protein chemistry · doi:10.1016/s0065-3233(07)74001-9 · Cited by 100 · see citing works

When 7 transmembrane receptors are not G protein-coupled receptors

Rajagopal, K. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26950 · Cited by 100 · see citing works

Essential role for Gα 13 in endothelial cells during embryonic development

Ruppel, K. M., Willison, D., Kataoka, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503326102 · Cited by 96 · see citing works

Trio’s Rho-specific GEF domain is the missing Gαq effector in C. elegansPreprint

Williams, S. L., Lutz, S., Charlie, N. K., Vettel, C., Ailion, M., Coco, C., Tesmer, J. J. G., Jørgensen, E. M., Wieland, T., & Miller, K. G. (2007) · Genes & Development · doi:10.1101/gad.1592007 · Cited by 95 · see citing works

Activation of G-protein Gα subunits by receptors through Gα–Gβ and Gα–Gγ interactions

Cherfils, J., & Chabre, M. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)00006-3 · Cited by 94 · see citing works

Mechanism of agonist and antagonist binding to .alpha.2 adrenergic receptors: evidence for a precoupled receptor-guanine nucleotide protein complex

Neubig, R. R., Gantzos, R. D., & Thomsen, W. J. (1988) · Biochemistry · doi:10.1021/bi00407a019 · Cited by 94 · see citing works

Human Phosphatidylethanolamine-binding Protein Facilitates Heterotrimeric G Protein-dependent Signaling

Kroslak, T., Koch, T., Kahl, E., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106991200 · Cited by 92 · see citing works

The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction

Waters, C. M., Pyne, S., & Pyne, N. J. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2003.12.020 · Cited by 90 · see citing works

Resistance to inhibitors of cholinesterase 8A catalyzes release of Gαi-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Gαi-GDP complexes

Tall, G. G., & Gilman, A. G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508306102 · Cited by 88 · see citing works

Cortical localization of the Gα protein GPA-16 requires RIC-8 function duringC. elegansasymmetric cell division

Afshar, K., Willard, F. S., Colombo, K., et al. (2005) · Development · doi:10.1242/dev.02039 · Cited by 81 · see citing works

Conformational Activation of Radixin by G13 Protein α Subunit

Vaiškunaite, R., Adarichev, V. A., Furthmayr, H., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001863200 · Cited by 81 · see citing works

Csk, a Critical Link of G Protein Signals to Actin Cytoskeletal Reorganization

Lowry, W. E., Huang, J., Ma, Y. C., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00175-2 · Cited by 80 · see citing works

GIV/Girdin Transmits Signals from Multiple Receptors by Triggering Trimeric G Protein Activation

Garcia‐Marcos, M., Ghosh, P., & Farquhar, M. G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.613414 · Cited by 79 · see citing works

The G Protein Gα13 Is Required for Growth Factor-Induced Cell Migration

Shan, D., Chen, L., Wang, D., Tan, Y.-C., Gu, J. L., & Huang, X. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.014 · Cited by 78 · see citing works

Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits

Chan, P., Thomas, C. J., Sprang, S. R., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220943110 · Cited by 76 · see citing works

Interactions of the α-subunits of heterotrimeric G-proteins with GPCRs, effectors and RGS proteins: A critical review and analysis of interacting surfaces, conformational shifts, structural diversity and electrostatic potentials

Baltoumas, F. A., Theodoropoulou, M. C., & Hamodrakas, S. J. (2013) · Journal of Structural Biology · doi:10.1016/j.jsb.2013.03.004 · Cited by 76 · see citing works

GIV is a Non‐Receptor GEF for Gαi with a Unique Motif that Regulates Akt Signaling

Garcia‐Marcos, M., Ghosh, P., Ear, J., et al. (2009) · The FASEB Journal · doi:10.1096/fasebj.23.1_supplement.879.1 · Cited by 72 · see citing works

Interaction of Gα12 and Gα13 with the cytoplasmic domain of cadherin provides a mechanism for β-catenin release

Meigs, T. E., Fields, T. A., McKee, D. D., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.519 · Cited by 70 · see citing works

Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-mice.

Rudolph, U., Spicher, K., & Birnbaumer, L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3209 · Cited by 68 · see citing works

Ric-8A Catalyzes Guanine Nucleotide Exchange on Gαi1 Bound to the GPR/GoLoco Exchange Inhibitor AGS3

Thomas, C. J., Tall, G. G., Adhikari, A., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802422200 · Cited by 66 · see citing works

Ric-8B Is a GTP-dependent G Protein αs Guanine Nucleotide Exchange Factor

Chan, P., Gabay, M., Wright, F. A., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.163675 · Cited by 64 · see citing works

The Juxtamembrane, Cytosolic Region of the Epidermal Growth Factor Receptor Is Involved in Association with α-Subunit of Gs

Sun, H., Chen, Z., Poppleton, H., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5413 · Cited by 60 · see citing works

Increased Insulin Sensitivity in Gsα Knockout Mice

Yu, S., Castle, A. L., Chen, M., Lee, R., Takeda, K., & Weinstein, L. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010313200 · Cited by 55 · see citing works

The quest to understand heterotrimeric G protein signaling

Tesmer, J. J. G. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb0610-650 · Cited by 53 · see citing works

GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression

Ghosh, P., Garcia‐Marcos, M., & Farquhar, M. G. (2011) · Cell Adhesion & Migration · doi:10.4161/cam.5.3.15909 · Cited by 53 · see citing works

The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegansPreprint

Steven, R. M., Zhang, L., Culotti, J. G., & Pawson, T. J. (2005) · Genes & Development · doi:10.1101/gad.1319905 · Cited by 53 · see citing works

Transmembrane signaling by GPCRs: Insight from rhodopsin and opsin structures

Choe, H., Park, J. H., Kim, Y. J., & Ernst, O. P. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.07.018 · Cited by 51 · see citing works

Heterotrimeric G Protein Signaling Outside the Realm of Seven Transmembrane Domain Receptors

Marty, C., & Ye, R. D. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.063453 · Cited by 51 · see citing works

Establishment and characterization of adenoviral E1A immortalized cell lines derived from the rat suprachiasmatic nucleus

Earnest, D. J., Liang, F.-Q., DiGiorgio, S., Gallagher, M., Harvey, B. K., Earnest, B. J., & Seigel, G. M. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199904)39:1 · Cited by 49 · see citing works

Characterization of a G-protein Activator in the Neuroblastoma-Glioma Cell Hybrid NG108-15

Sato, M., Ribas, C., Hildebrandt, J. D., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.30052 · Cited by 49 · see citing works

Regulator of G Protein Signaling Proteins as Drug Targets: Current State and Future Possibilities

Sjögren, B. (2011) · Advances in pharmacology · doi:10.1016/b978-0-12-385952-5.00002-6 · Cited by 48 · see citing works

PDGF and neomycin induce similar changes in the actin cytoskeleton in human fibroblasts

Hedberg, K. M., Bengtsson, T., Safiejko‐Mroczka, B., et al. (1993) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970240207 · Cited by 46 · see citing works

Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time

Aznar, N., Kalogriopoulos, N. A., Midde, K., & Ghosh, P. (2016) · BioEssays · doi:10.1002/bies.201500133 · Cited by 46 · see citing works

Prognostic Impact of Modulators of G proteins in Circulating Tumor Cells from Patients with Metastatic Colorectal Cancer

Barbazán, J., Dunkel, Y., Li, H., Nitsche, U., Janssen, K., Messer, K. S., & Ghosh, P. (2016) · Scientific Reports · doi:10.1038/srep22112 · Cited by 43 · see citing works

Signaling mechanisms of GPCR ligands.

Strange, P. G. (2008) · PubMed · Cited by 36 · see citing works

Platelet‐derived growth factor (PDGF)‐induced chemotaxis does not require the G protein‐coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells

Kluk, M., Colmont, C. S., Wu, M.-T., et al. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03742-0 · Cited by 34 · see citing works

G Proteins G12 and G13 Control the Dynamic Turnover of Growth Factor-induced Dorsal Ruffles

Wang, D., Tan, Y.-C., Kreitzer, G. E., Nakai, Y., Shan, D., Zheng, Y., & Huang, X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604588200 · Cited by 33 · see citing works

Cytoskeletal changes associated with cell motility.

Warn, R. M., Brown, D., Dowrick, P. G., et al. (1993) · PubMed · Cited by 33 · see citing works

Resistance to Inhibitors of Cholinesterase-8A (Ric-8A) Is Critical for Growth Factor Receptor-induced Actin Cytoskeletal Reorganization

Wang, L., Guo, D., Xing, B., Zhang, J. J., Shu, H., Guo, L., & Huang, X.-Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.253427 · Cited by 32 · see citing works

Heterozygous mice with Ric-8 mutation exhibit impaired spatial memory and decreased anxiety

Tõnissoo, T., Kõks, S., Meier, R., et al. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.08.025 · Cited by 26 · see citing works

Purification and Functional Analysis of Ric-8A: A Guanine Nucleotide Exchange Factor for G-Protein α Subunits

Tall, G. G., & Gilman, A. G. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)90023-7 · Cited by 23 · see citing works

The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1

Eps, N. V., Thomas, C. J., Hubbell, W. L., & Sprang, S. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423878112 · Cited by 22 · see citing works

Snapshot of a signalling complex

Schwartz, T. W., & Sakmar, T. P. (2011) · Nature · doi:10.1038/477540a · Cited by 15 · see citing works

Evidence Mounts for Receptor-Independent Activation of Heterotrimeric G Proteins Normally in Vivo: Positioning of the Mitotic Spindle in C. Elegans

Manning, D. R. (2003) · Science s STKE · doi:10.1126/stke.2003.196.pe35 · Cited by 14 · see citing works

Atypical Protein Kinase Cλ Is Critical for Growth Factor Receptor-induced Dorsal Ruffle Turnover and Cell Migration

Xing, B., Wang, L., Guo, D., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.489427 · Cited by 11 · see citing works

Pivotal Role of Extended Linker 2 in the Activation of Gα by G Protein-coupled Receptor

Huang, J., Sun, Y., Zhang, J. J., & Huang, X.-Y. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.608661 · Cited by 10 · see citing works

Signaling of Gα12 Family of G Proteins Through a Tyrosine Kinase and a Ras-GAP

Cvejic, S. (2000) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(00)00054-2 · Cited by 9 · see citing works

How GPCRs hit the switch

Ramachandran, S., & Cerione, R. A. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb0906-756 · Cited by 7 · see citing works

The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factor

Huang, W., Morales, J. L., Gazivoda, V. P., et al. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.02.011 · Cited by 7 · see citing works

Intrinsically disordered proteins play diverse roles in cell signaling

Bondos, S. E., Dunker, A. K., & Uversky, V. N. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00821-7 · Cited by 222 · see citing works

Single-cell transcriptomic evidence for dense intracortical neuropeptide networks

Smith, S. J., Sümbül, U., Graybuck, L. T., Collman, F., Seshamani, S., Gala, R., Gliko, O., Elabbady, L., Miller, J. A., Bakken, T. E., et al. (2019) · eLife · doi:10.7554/elife.47889 · Cited by 156 · see citing works

Multi-functionality of proteins involved in GPCR and G protein signaling: making sense of structure–function continuum with intrinsic disorder-based proteoforms

Fonin, A. V., Darling, A. L., Kuznetsova, I. M., Turoverov, K. K., & Uversky, V. N. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03276-1 · Cited by 91 · see citing works

The GPR17 receptor-A promising goal for therapy and a potential marker of the neurodegenerative process in multiple sclerosis

Dziedzic, A., Miller, E., Saluk-Bijak, J., & Bijak, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051852 · Cited by 38 · see citing works

Signatures of Selection in Nelore Cattle Revealed by Whole-Genome Sequencing Data

Maiorano, A. M., Cardoso, D. F., Carvalheiro, R., Júnior, G. A. F., de Albuquerque, L. G., & de Oliveira, H. N. (2022) · Genomics · doi:10.1016/j.ygeno.2022.110304 · Cited by 33 · see citing works

New light on cortical neuropeptides and synaptic network plasticity

Smith, S. J., Hawrylycz, M., Rossier, J., & Sümbül, U. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.04.002 · Cited by 26 · see citing works

Cholinergic and Adenosinergic Modulation of Synaptic Release

Yang, D., Ding, C., Qi, G., & Feldmeyer, D. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2020.06.006 · Cited by 24 · see citing works

Gq-Induced Apoptosis is Mediated by AKT Inhibition That Leads to PKC-Induced JNK Activation

Nadel, G., Yao, Z., Ben-Ami, I., Naor, Z., & Seger, R. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493963 · Cited by 20 · see citing works

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

Watson, N., Linder, M. E., Druey, K. M., Kehrl, J. H., & Blumer, K. (1996) · Nature · doi:10.1038/383172a0 · Cited by 546 · see citing works

GTPase-Activating Proteins for Heterotrimeric G Proteins: Regulators of G Protein Signaling (RGS) and RGS-Like Proteins

Ross, E. M., & Wilkie, T. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.795 · Cited by 1,157 · see citing works

Regulators of G-protein signalling: a novel protein family involved in timely deactivation and desensitization of signalling via heterotrimeric G proteins

Wieland, T., & Chen, C.-K. (1999) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002109900031 · Cited by 68 · see citing works

Established and Emerging Fluorescence-Based Assays for G-Protein Function: Heterotrimeric G-Protein Alpha Subunits and Regulator of G-Protein Signaling (RGS) Proteins

Kimple, R. J., Jones, M. B., Shutes, A., Yerxa, B. R., Siderovski, D. P., & Willard, F. S. (2003) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/138620703106298491 · Cited by 31 · see citing works

Measurement of GTP-Binding and GTPase Activity of Heterotrimeric Gα Proteins

Choudhury, S. R., Westfall, C. S., Hackenberg, D., et al. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-532-3_2 · Cited by 24 · see citing works