RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
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Ga12/13 subunits directly activate a class of RhoGEFs including p115-RhoGEF, PDZ-RhoGEF, LARG and Lbc-RhoGEF that contain Ga-binding RH domains.
“Ga 12/13 subunits directly activate a class of RhoGEFs including p115-RhoGEF, PDZ-RhoGEF, LARG and Lbc-RhoGEF 11,12 that contain Ga-binding RH domains.”
From Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1 (2014) · cites this paper as [11]
Cites
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392 · see citing works
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Activation of Platelet Function Through G Protein–Coupled Receptors
Offermanns, S. (2006) · Circulation Research · doi:10.1161/01.res.0000251742.71301.16 · Cited by 725 · see citing works
AGE restriction in diabetes mellitus: a paradigm shift
Vlassara, H., & Striker, G. E. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.74 · Cited by 277 · see citing works
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273 · see citing works
Desale, S. E., Chidambaram, H., & Chinnathambi, S. (2021) · Molecular Biomedicine · doi:10.1186/s43556-021-00036-1 · Cited by 99 · see citing works
Meiri, D., Marshall, C. B., Mokady, D., LaRose, J., Mullin, M., Gingras, A.-C., Ikura, M., & Rottapel, R. (2014) · Nature Communications · doi:10.1038/ncomms5857 · Cited by 70 · see citing works
- Authors
- Fukuhara, S., Chikumi, H., & Gutkind, J. S.
- Affiliations
- National Institutes of Health (US)
- Venue
- Oncogene
- Published
- 2001-03-26
- Volume
- 20
- Issue
- 13
- Pages
- 1661-1668
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2325421187
- Cited by
- 219
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 8 · 2013: 8 · 2012: 8
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- RhoGEF, RhoA, RhoB, RhoC, RhoD, RhoE, Rho GTPases, G protein-coupled receptors, Rho GTPase signaling
- MeSH terms
- Cell Transformation, Neoplastic, Models, Biological, Signal Transduction, Guanine Nucleotide Exchange Factors, RGS Proteins, rho GTP-Binding Proteins, Heterotrimeric GTP-Binding Proteins, Rho Guanine Nucleotide Exchange Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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