Cited by 3,047Cancer-related Molecular PathwaysDNA Repair MechanismsEffects of Radiation Exposure

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Kastan, Michael B., Zhan, Qimin, El-Deiry, Wafik S., Carrier, France, Jacks, Tyler, Walsh, William V., Plunkett, Beverly S., Vogelstein, Bert, Fornace, Albert J.·1992·Cell

DOI 10.1016/0092-8674(92)90593-2

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Abstract

Cell cycle checkpoints can enhance cell survival and limit mutagenic events following DNA damage. Primary murine fibroblasts became deficient in a G1 checkpoint activated by ionizing radiation (IR) when both wild-type p53 alleles were disrupted. In addition, cells from patients with the radiosensitive, cancer-prone disease ataxia-telangiectasia (AT) lacked the IR-induced increase in p53 protein levels seen in normal cells. Finally, IR induction of the human GADD45 gene, an induction that is also defective in AT cells, was dependent on wild-type p53 function. Wild-type but not mutant p53 bound strongly to a conserved element in the GADD45 gene, and a p53-containing nuclear factor, which bound this element, was detected in extracts from irradiated cells. Thus, we identified three participants (AT gene(s), p53, and GADD45) in a signal transduction pathway that controls cell cycle arrest following DNA damage; abnormalities in this pathway probably contribute to tumor development.

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
Self-citation
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., & Howley, P. M. (1990) · Cell · doi:10.1016/0092-8674(90)90409-8 · Cited by 3,995
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Doll, R., & Peto, R. (1981) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/66.6.1192 · Cited by 3,927 · cited 1×
“Discussion Exposure to DNA-damaging agents probably contributes to the development of a significant percentage of human cancers (Doll and Peto, 1981).”
Background
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
Self-citation
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Peto, R. (1983) · Springer eBooks · doi:10.1007/978-1-4757-1117-2_30 · Cited by 3,504
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113

Show all 64 references

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Miller, S. J., Rangwala, F. A., Williams, J. P., Ackerman, P., Kong, S., Jegga, A. G., Kaiser, S., Aronow, B. J., Frahm, S., Kluwe, L., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3330 · Cited by 207
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Setton, J. S., Zinda, M. J., Riaz, N., Durocher, D., Zimmermann, M., Koehler, M. T., Reis-Filho, J. S., & Powell, S. N. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1503 · Cited by 214
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Kapoor, M., & Lozano, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2834 · Cited by 209
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Schüler, M., Herrmann, R., Grève, J. D., Stewart, A. K., Gatzemeier, U., Stewart, D. J., Laufman, L. R., Gralla, R. J., Kuball, J. H. E., Buhl, R., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.6.1750 · Cited by 210
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Landers, J. E., Cassel, S., & George, D. L. (1997) · PubMed · Cited by 210
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Heyer, B. S., MacAuley, A., Behrendtsen, O., & Werb, Z. (2000) · Genes & Development · doi:10.1101/gad.14.16.2072 · Cited by 208
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Lee, H., & Kimelman, D. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00166-1 · Cited by 209
ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity.
Angèle, S., Romestaing, P., Moullan, N., Vuillaume, M., Chapot, B., Friesen, M. D., Jongmans, W., Cox, D. G., Pisani, P., Gérard, J. P., et al. (2003) · PubMed · Cited by 208
Reprimo, a New Candidate Mediator of the p53-mediated Cell Cycle Arrest at the G2 Phase
Ohki, R., Nemoto, J., Murasawa, H., Oda, E., Inazawa, J., Tanaka, N., & Taniguchi, T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000235200 · Cited by 201
The Ionizing Radiation-Induced Replication Protein A Phosphorylation Response Differs between Ataxia Telangiectasia and Normal Human Cells
Liu, V. F., & Weaver, D. T. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7222 · Cited by 207
Tumor suppressor genes
Hinds, P. W., & Weinberg, R. A. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90102-3 · Cited by 210
GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activity
Jin, S., Tong, T., Fan, W., Fan, F., Antinore, M. J., Zhu, X., Mazzacurati, L., Li, X., Petrik, K. L., Rajasekaran, B., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1206034 · Cited by 205
Self-citation
From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging
Vaziri, H., & Benchimol, S. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(95)02025-x · Cited by 209
Perturbation of Cell Cycle Progression and Cellular Gene Expression as a Function of Herpes Simplex Virus ICP0
Hobbs, W. E., & DeLuca, N. A. (1999) · Journal of Virology · doi:10.1128/jvi.73.10.8245-8255.1999 · Cited by 206
Stimulation of p53-mediated Transcriptional Activation by the p53-binding Proteins, 53BP1 and 53BP2
Iwabuchi, K., Li, B., Massa, H. F., Trask, B. J., Date, T., & Fields, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.26061 · Cited by 206
Comparative Binding of p53 to its Promoter and DNA Recognition Elements
Weinberg, R. L., Veprintsev, D. B., Bycroft, M., & Fersht, A. R. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.03.014 · Cited by 211
Regulation of V(D)J Recombination Activator Protein RAG-2 by Phosphorylation
Lin, W.-C., & Desiderio, S. V. (1993) · Science · doi:10.1126/science.8493533 · Cited by 204
Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage
Zhan, Q. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.06.055 · Cited by 204
Self-citation
Enhancement of DNA repair in human skin cells by thymidine dinucleotides: Evidence for a p53-mediated mammalian SOS response
Eller, M. S., Maeda, T., Magnoni, C., Atwal, D., & Gilchrest, B. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12627 · Cited by 204
Pathophysiology of perinatal brain damage
Berger, R. E., & Garnier, Y. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00009-0 · Cited by 201
p53 Signaling and Cell Cycle Checkpoints
Stewart, Z. A., & Pietenpol, J. A. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000199t · Cited by 204
The GADD45 Inhibition of Cdc2 Kinase Correlates with GADD45-mediated Growth Suppression
Jin, S., Antinore, M. J., Lung, F. T., Dong, X. Z., Zhao, H., Fan, F., Colchagie, A. B., Blanck, P., Roller, P. P., Fornace, A. J., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000284200 · Cited by 202
Self-citation
p53-dependent pathways of apoptosis
Benchimol, S. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400918 · Cited by 204
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
Olsson, A., Manzl, C., Strasser, A., & Villunger, A. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402196 · Cited by 204
Tyrosine phosphorylation of Mdm2 by c‐Abl: implications for p53 regulation
Goldberg, Z., Sionov, R. V., Berger, M., Zwang, Y., Perets, R., Etten, R. A. V., Oren, M., Taya, Y., & Haupt, Y. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf384 · Cited by 200
High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation
Li, X., & Coffino, P. (1996) · Journal of Virology · doi:10.1128/jvi.70.7.4509-4516.1996 · Cited by 200
Differential Transactivation by the p53 Transcription Factor Is Highly Dependent on p53 Level and Promoter Target Sequence
Inga, A., Storici, F., Darden, T. A., & Resnick, M. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8612-8625.2002 · Cited by 195
Cancer Risk and the ATM Gene: a Continuing Debate
Khanna, K. K. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.10.795 · Cited by 200
Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents.
Tishler, R. B., Calderwood, S. K., Coleman, C. N., & Price, B. D. (1993) · PubMed · Cited by 200
Transcriptional repression mediated by the p53 tumour suppressor
Ho, J., & Benchimol, S. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401191 · Cited by 203
p53 C-Terminal Phosphorylation by CHK1 and CHK2 Participates in the Regulation of DNA-Damage-induced C-Terminal Acetylation
Ou, Y.-H., Chung, P.-H., Sun, T.-P., & Shieh, S.-Y. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0689 · Cited by 211
Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination
Nakamura, S., Roth, J. A., & Mukhopadhyay, T. K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.24.9391-9398.2000 · Cited by 198
ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth
Fan, F., Jin, S., Amundson, S. A., Tong, T., Fan, W., Zhao, H., Zhu, X., Mazzacurati, L., Li, X., Petrik, K. L., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205896 · Cited by 198
Self-citation
Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways
Barlow, C., Brown, K. D., Deng, C., Tagle, D. A., & Wynshaw-Boris, A. J. (1997) · Nature Genetics · doi:10.1038/ng1297-453 · Cited by 198
Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells
Fuchs, D., Heinold, A., Opelz, G., Daniel, V., & Naujokat, C. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.10.042 · Cited by 200
Role of Gadd45 in apoptosis
Sheikh, M. S., Hollander, M. C., & Fornace, A. J. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00291-9 · Cited by 196
Self-citation
RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae.
Siede, W., Friedberg, A. S., & Friedberg, E. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7985 · Cited by 195
Activated p53 suppresses the histone methyltransferase EZH2 gene
Tang, X., Milyavsky, M., Shats, I., Erez, N., Goldfinger, N., & Rotter, V. (2004) · Oncogene · doi:10.1038/sj.onc.1207706 · Cited by 193
Activation of c- myc Gene Expression by Tumor-Derived p53 Mutants Requires a Discrete C-Terminal Domain
Frazier, M. W., He, X., Wang, J., Gu, Z., Cleveland, J. L., & Zambetti, G. P. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3735 · Cited by 194
Molecular Biology of Fanconi Anemia: Implications for Diagnosis and Therapy
D’Andrea, A. D., & Grompe, M. (1997) · Blood · doi:10.1182/blood.v90.5.1725 · Cited by 194
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Borel, F., Lohez, O. D., Lacroix, F., & Margolis, R. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152205299 · Cited by 196
Structure, Function, and Aggregation of the Zinc-Free Form of the p53 DNA Binding Domain
Butler, J. S., & Loh, S. N. (2003) · Biochemistry · doi:10.1021/bi026635n · Cited by 190
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Schiller, J. H., Adak, S., Feins, R. H., Keller, S. M., Fry, W. A., Livingston, R. B., Hammond, M. E., Wolf, B. C., Sabatini, L. M., Jett, J. R., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.2.448 · Cited by 192
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Nikolova, T., Czyż, J., Rolletschek, A., Błyszczuk, P., Fuchs, J., Jovtchev, G., Schulderer, J., Kuster, N., & Wobus, A. M. (2005) · The FASEB Journal · doi:10.1096/fj.04-3549fje · Cited by 192
Expression of retinoic acid receptor beta mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells.
Seewaldt, V. L., Johnson, B. S., Parker, M. B., Collins, S., & Swisshelm, K. L. (1995) · PubMed · Cited by 192
Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer
Artandi, S. E., & Attardi, L. D. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.211 · Cited by 194
Nonhomologous end joining and V(D)J recombination require an additional factor
Dai, Y., Kysela, B. P., Hanakahi, L. A., Manolis, K. G., Riballo, E., Stümm, M., Harville, T., West, S. C., Oettinger, M. A., & Jeggo, P. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437964100 · Cited by 199
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Gately, D. P., Hittle, J. C., Chan, G. K. T., & Yen, T. J. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.9.2361 · Cited by 191
Radiosensitivity in Ataxia-telangiectasia: Anomalies in Radiation-induced Cell Cycle Delay
Beamish, H., & Lavin, M. F. (1994) · International Journal of Radiation Biology · doi:10.1080/09553009414550211 · Cited by 192
Modulation of p53-Mediated Transcriptional Repression and Apoptosis by the Adenovirus E1B 19K Protein
Sabbatini, P., Chiou, S., Rao, L., & White, E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.1060 · Cited by 191
Localization of a Portion of Extranuclear ATM to Peroxisomes
Watters, D. J., Kedar, P. S., Spring, K. J., Björkman, J., Chen, P., Gatei, M. H., Birrell, G. W., Garrone, B., Srinivasa, P., Crane, D. I., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34277 · Cited by 190
DNA Damage Responses: Mechanisms and Roles in Human Disease
Kastan, M. B. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0020 · Cited by 198
Self-citation
CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate
Stolařová, L., Kleiblová, P., Janatová, M., Soukupová, J., Zemánková, P., Macůrek, L., & Kleibl, Z. (2020) · Cells · doi:10.3390/cells9122675 · Cited by 197
Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.
Xu, B., O’Donnell‐Luria, A., Kim, S., & Kastan, M. B. (2002) · PubMed · Cited by 189
Self-citation
The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy
Bristow, R. G., Benchimol, S., & Hill, R. P. (1996) · Radiotherapy and Oncology · doi:10.1016/0167-8140(96)01806-3 · Cited by 191
Activation of the cryptic DNA binding function of mutant forms of p53
Hupp, T. R., Meek, D. W., Midgley, C., & Lane, D. P. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.14.3167 · Cited by 190
The C-terminal lysines fine-tune p53 stress responses in a mouse model, but are not required for stability control or transactivation
Krummel, K. A., Lee, C. J., Toledo, F., & Wahl, G. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503068102 · Cited by 187
Lessons learned from BRCA1 and BRCA2
Zheng, L., Li, S., Boyer, T., & Lee, W. (2000) · Oncogene · doi:10.1038/sj.onc.1203968 · Cited by 187
Mice Lacking the p53-Effector Gene Gadd45a Develop a Lupus-Like Syndrome
Salvador, J. M., Hollander, M. C., Nguyen, A. T., Kopp, J. B., Barisoni, L. M. C., Moore, J. K., Ashwell, J. D., & Fornace, A. J. (2002) · Immunity · doi:10.1016/s1074-7613(02)00302-3 · Cited by 188
Self-citation
The Saccharomyces cerevisiae Ku Autoantigen Homologue Affects Radiosensitivity Only in the Absence of Homologous Recombination
Siede, W., Friedl, A. A., Dianova, I. I., Eckardt‐Schupp, F., & Friedberg, E. C. (1996) · Genetics · doi:10.1093/genetics/142.1.91 · Cited by 188
Induction of Stress Genes by Low Doses of Gamma Rays
Amundson, S. A., Do, K. T., & Fornace, A. J. (1999) · Radiation Research · doi:10.2307/3580321 · Cited by 187
Self-citation
The p53 gene and its role in human brain tumors
Bögler, O., Huang, H., Kleihues, P., & Cavenee, W. K. (1995) · Glia · doi:10.1002/glia.440150311 · Cited by 189
The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.
Reed, M. J., Woelker, B., Wang, P., Wang, Y., Anderson, M. E., & Tegtmeyer, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9455 · Cited by 187
p53 Expression: Predicting Recurrence and Second Primary Tumors in Head and Neck Squamous Cell Carcinoma
Shin, D. M., Lee, J., Lippman, S. M., Lee, J. J., Tu, Z. N., Choi, G., Heyne, K., Shin, H. J. C., Ro, J. Y., Goepfert, H., et al. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.8.519 · Cited by 186
UV light‐induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single‐stranded DNA‐binding protein.
Carty, M. P., Zernik-Kobak, M., McGrath, S., & Dixon, K. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06487.x · Cited by 186
The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
Brush, G. S., Morrow, D. M., Hieter, P., & Kelly, T. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15075 · Cited by 185
mtCLIC/CLIC4, an Organellular Chloride Channel Protein, Is Increased by DNA Damage and Participates in the Apoptotic Response to p53
Fernández‐Salas, E., Suh, K. S., Speransky, V. V., Bowers, W. L., Levy, J. M., Adams, T., Pathak, K. R., Edwards, L. E., Hayes, D. D., Cheng, C., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3610-3620.2002 · Cited by 182
Multisite Phosphorylation and the Integration of Stress Signals at p53
Meek, D. W. (1998) · Cellular Signalling · doi:10.1016/s0898-6568(97)00119-8 · Cited by 185
Inducing autoimmune disease to treat cancer
Pardoll, D. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5340 · Cited by 184
Understanding and controlling the cell cycle with natural products
Hung, D. T., Jamison, T. F., & Schreiber, S. L. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90129-5 · Cited by 183
IL-4, but not vitamin D3, induces monoblastic cell line UG3 to differentiate into multinucleated giant cells on osteoclast lineage
Kaji, Y., Ikeda, K., Ikeda, T., Kawakami, K., Sasaki, K., Shindo, M., Hatake, K., Harada, M., Motoyoshi, K., Mori, S., et al. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200002)182:2 · Cited by 10
Self-citation
The Novel Primary Response Gene MyD118 and the Proto-Oncogenes myb , myc , and bcl-2 Modulate Transforming Growth Factor β1-induced Apoptosis of Myeloid Leukemia Cells
Selvakumaran, M., Lin, H., Sjin, R. T. T., Reed, J. C., Liebermann, D. A., & Hoffman‐Liebermann, B. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.4.2352 · Cited by 183
Transcriptional Activation of the Human Epidermal Growth Factor Receptor Promoter by Human p53
Ludes-Meyers, J. H., Subler, M. A., Shivakumar, C. V., Muñoz, R. M., Jiang, P., Bigger, J. E., Brown, D. R., Deb, S. P., & Deb, S. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6009 · Cited by 185
Cell cycle regulation of V(D)J recombination-activating protein RAG-2.
Lin, W.-C., & Desiderio, S. V. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.7.2733 · Cited by 183
ATM binds to β-adaptin in cytoplasmic vesicles
Lim, D., Kirsch, D. G., Canman, C. E., Ahn, J.-H., Ziv, Y., Newman, L. S., Darnell, R. B., Shiloh, Y., & Kastan, M. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10146 · Cited by 181
Self-citation
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Authors: Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J.
Affiliations: Johns Hopkins University (US)
National Cancer Institute (US)
Massachusetts Institute of Technology (US)
ORCID: Kastan, Michael B.
Zhan, Qimin
Carrier, France
Jacks, Tyler
Vogelstein, Bert
Fornace, Albert J.
Venue: Cell
Publisher: Elsevier BV
Published: 1992-11
Volume: 71
Issue: 4
Pages: 587-597
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(92)90593-2
OpenAlex: W1986179131
Cited by: 3,047
References: 64
Citations by year: 2026: 11 · 2025: 16 · 2024: 17 · 2023: 20 · 2022: 23 · 2021: 23 · 2020: 24 · 2019: 16 · 2018: 31 · 2017: 34 · 2016: 35 · 2015: 43 · 2014: 44 · 2013: 30 · 2012: 48
FWCI: 86.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 09071, CA43460, T32CA009071)
National Institute of Environmental Health Sciences (ES05777)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords: ataxia telangiectasia, p53, GADD45, cell cycle checkpoints, G1/S checkpoint, ionizing radiation, DNA damage response, cell cycle arrest, signal transduction, cancer susceptibility, radiosensitivity
MeSH terms: Amino Acid Sequence, Animals, Ataxia Telangiectasia, Base Sequence, Cell Cycle, Cell Line, Cloning, Molecular, DNA Damage, DNA Repair, Gene Expression Regulation, Humans, Molecular Sequence Data, Genes, p53, Mutagenesis, Mice

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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