The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor
Abstract
Cellular receptors are required for efficient entry of retroviruses into cells. We previously cloned a chicken gene responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus (RSV(A)). Here we have isolated the quail homolog and generated two alternatively spliced processed genes encoding cellular receptors for RSV(A). Predicted products of the processed genes appear to be small membrane-associated proteins with identical 83 amino acid extracellular domains but different membrane anchors. Within the extracellular domain is a region closely related to the ligand-binding repeat of the low density lipoprotein receptor (LDLR). Expression of either processed gene renders mammalian cells specifically susceptible to RSV(A). Antibodies directed against the receptor block subgroup A infection of avian cells via endogenous receptors and have no effect on entry of other RSV subgroups. Thus, small LDLR-related proteins are cellular receptors for RSV(A).
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“Thus, LRAD3, pg800 and pg950 may define a new sub-family of receptors which are closely related to the LDL receptor by the presence of one or more LDLa repeats in their extracellular domains, but which lack the other LDL receptor family motifs.”
From LRAD3, A Novel Low-Density Lipoprotein Receptor Family Member That Modulates Amyloid Precursor Protein Trafficking (2011) · cites this paper as Bates et al., 1993
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Metadata
- Authors
- Bates, P., Young, J. A. T., & Varmus, H. E.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1993-09
- Volume
- 74
- Issue
- 6
- Pages
- 1043-1051
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1969563526
- Cited by
- 355
- References
- 38
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 10 · 2016: 3 · 2015: 13 · 2014: 11 · 2013: 12 · 2012: 8
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r35ca039832-08)
- National Cancer Institute (CA 39832)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- cell receptors, LDL receptor, alternative splicing, membrane-associated proteins, chickens, quail, avian cells
- MeSH terms
- Amino Acid Sequence, Animals, Avian Sarcoma Viruses, Base Sequence, Cell Line, Chick Embryo, Chickens, Cloning, Molecular, DNA, Glutathione Transferase, Humans, Molecular Sequence Data, Plasmids, Quail, Receptors, LDL, Receptors, Virus, Recombinant Fusion Proteins, Transfection, Gene Library, 3T3 Cells, Sequence Homology, Amino Acid, Mice
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