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The LDL receptor gene: a mosaic of exons shared with different proteins.
Abstract
The multifunctional nature of coated pit receptors predicts that these proteins will contain multiple domains. To establish the genetic basis for these domains, we have determined the exon organization of the gene for the low-density lipoprotein (LDL) receptor. This gene is more than 45 kilobases in length and contains 18 exons, most of which correlate with functional domains previously defined at the protein level. Thirteen of the 18 exons encode protein sequences that are homologous to sequences in other proteins: five of these exons encode a sequence similar to one in the C9 component of complement; three exons encode a sequence similar to a repeat sequence in the precursor for epidermal growth factor (EGF) and in three proteins of the blood clotting system (factor IX, factor X, and protein C); and five other exons encode nonrepeated sequences that are shared only with the EGF precursor. The LDL receptor appears to be a mosaic protein built up of exons shared with different proteins, and it therefore belongs to several supergene families.
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LDLR spans the plasma membrane with a single simple transmembrane domain, lacking a GPI anchor.
“LDLR spans the plasma membrane with a single simple transmembrane domain, lacking a GPI anchor13.”
From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [13]
The mature LDLR protein contains 839 amino acids.
“The mature LDLR protein contains 839 amino acids”
From ENO1–BACE2-mediated LDLR cleavage promotes liver cancer progression by remodelling cholesterol metabolism (2025) · cites this paper as Sudhof et al., 1985
LDLR is a membrane-spanning glycoprotein that plays a critical role in removing LDL and VLDL from the blood.
“LDLR is a membrane-spanning glycoprotein that plays a critical role in removing LDL and VLDL from the blood [16], [17].”
From LDLR Expression and Localization Are Altered in Mouse and Human Cell Culture Models of Alzheimer's Disease (2010) · cites this paper as [17]
LDLR is a type I membrane protein with an extracellular/luminal N-terminus, a single transmembrane helix, and a cytosolic C-terminus.
“LDLR is a type I membrane protein, meaning that it possesses an extracellular/luminal N-terminus, followed by a single transmembrane helix and a cytosolic C-terminus, such that this integral membrane protein spans the entirety of the cell membrane11–13.”
From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [13]
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Citations
Cites
T cell antigen receptors and the immunoglobulin supergene family
Hood, L. (1985) · Cell · doi:10.1016/0092-8674(85)90133-3 · Cited by 433
Flagged first, then by citations
Research works printed but not linked: 46
- ANSON, D.S., THE GENE STRUCTURE OF HUMAN ANTI-HEMOPHILIC FACTOR-IX, EMBO JOURNAL 3: 1053 (1984). · DOI
- BERK, A.J., SIZING AND MAPPING OF EARLY ADENOVIRUS MESSENGER-RNAS BY GEL-ELECTROPHORESIS OF S1 ENDONUCLEASE-DIGESTED HYBRIDS, CELL 12: 721 (1977). · DOI
- BLOMQUIST, M.C., VACCINIA VIRUS-19-KILODALTON PROTEIN - RELATIONSHIP TO SEVERAL MAMMALIAN PROTEINS, INCLUDING 2 GROWTH-FACTORS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 7363 (1984).
- BROWN, M.S., RECYCLING RECEPTORS - THE ROUND-TRIP ITINERARY OF MIGRANT MEMBRANE-PROTEINS, CELL 32: 663 (1983). · DOI · Paper page
- CARTER, A.D., DUPLICATED HEAVY-METAL CONTROL SEQUENCES OF THE MOUSE METALLOTHIONEIN-I GENE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 7392 (1984).
- 10.1073/pnas.81.7.1991 · DOI
- CUMMINGS, R.D., BIOSYNTHESIS OF N-LINKED AND O-LINKED OLIGOSACCHARIDES OF THE LOW-DENSITY LIPOPROTEIN RECEPTOR, JOURNAL OF BIOLOGICAL CHEMISTRY 258: 15261 (1983). · DOI
- DISCIPIO, R.G., NUCLEOTIDE-SEQUENCE OF CDNA AND DERIVED AMINO-ACID-SEQUENCE OF HUMAN-COMPLEMENT COMPONENT-C9, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 7298 (1984).
- DOOLITTLE, R.F., COMPUTER-BASED CHARACTERIZATION OF EPIDERMAL GROWTH-FACTOR PRECURSOR, NATURE 307: 558 (1984). · DOI
- Doolittle, R. F., Trends in Biochemical Sciences 10: 233 (1985).
- DOOLITTLE, W.F., GENES IN PIECES - WERE THEY EVER TOGETHER, NATURE 272: 581 (1978). · DOI
- 10.1038/307521a0 · DOI · Paper page
- 10.1016/0003-2697(83)90418-9 · DOI
- GILBERT, W, WHY GENES IN PIECES, NATURE 271: 501 (1978). · DOI · Paper page
- GOLDSTEIN, J.L., RECEPTOR-MEDIATED ENDOCYTOSIS OF LOW-DENSITY LIPOPROTEIN IN CULTURED-CELLS, METHODS IN ENZYMOLOGY 98: 241 (1983). · DOI
- GOLDSTEIN, J.L., COATED PITS, COATED VESICLES, AND RECEPTOR-MEDIATED ENDOCYTOSIS, NATURE 279: 679 (1979). · DOI · Paper page
- GRAY, A, NUCLEOTIDE-SEQUENCE OF EPIDERMAL GROWTH-FACTOR CDNA PREDICTS A 128,000-MOLECULAR WEIGHT PROTEIN-PRECURSOR, NATURE 303: 722 (1983). · DOI
- GROSVELD, F.G., THE CONSTRUCTION OF COSMID LIBRARIES WHICH CAN BE USED TO TRANSFORM EUKARYOTIC CELLS, NUCLEIC ACIDS RESEARCH 10: 6715 (1982). · DOI
- HOLLAND, E.C., RAT-LIVER ASIALOGLYCOPROTEIN RECEPTOR LACKS A CLEAVABLE NH2-TERMINAL SIGNAL SEQUENCE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 7338 (1984).
- INNERARITY, T.L., NORMALIZATION OF RECEPTOR-BINDING OF APOLIPOPROTEIN-E2 - EVIDENCE FOR MODULATION OF THE BINDING-SITE CONFORMATION, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 7261 (1984). · DOI · Paper page
- KING, C.R., ALTERNATIVE RNA SPLICING OF THE MURINE ALPHA-A-CRYSTALLIN GENE - PROTEIN-CODING INFORMATION WITHIN AN INTRON, CELL 32: 707 (1983). · DOI
- LAU, Y.F., VERSATILE COSMID VECTORS FOR THE ISOLATION, EXPRESSION, AND RESCUE OF GENE-SEQUENCES - STUDIES WITH THE HUMAN ALPHA-GLOBIN GENE-CLUSTER, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80: 5225 (1983).
- LAWN, R.M., ISOLATION AND CHARACTERIZATION OF LINKED DELTA-GLOBIN AND BETA-GLOBIN GENES FROM A CLONED LIBRARY OF HUMAN DNA, CELL 15: 1157 (1978). · DOI
- Lehrman, M. A., Cell 41: 735 (1985). · DOI
- 10.1126/science.3155573 · DOI
- Maniatis, T., Molecular Cloning: A Laboratory Manual: 1 (1982).
- 10.1016/S0076-6879(80)65059-9 · DOI
- MCCLELLAND, A, THE HUMAN TRANSFERRIN RECEPTOR GENE - GENOMIC ORGANIZATION, AND THE COMPLETE PRIMARY STRUCTURE OF THE RECEPTOR DEDUCED FROM A CDNA SEQUENCE, CELL 39: 267 (1984). · DOI
- MEDFORD, R.M., A NOVEL MECHANISM OF ALTERNATIVE RNA SPLICING FOR THE DEVELOPMENTALLY REGULATED GENERATION OF TROPONIN-T ISOFORMS FROM A SINGLE GENE, CELL 38: 409 (1984). · DOI
- MESSING, J, NEW M13 VECTORS FOR CLONING, METHODS IN ENZYMOLOGY 101: 20 (1983). · DOI
- MOSTOV, K.E., THE RECEPTOR FOR TRANS-EPITHELIAL TRANSPORT OF IGA AND IGM CONTAINS MULTIPLE IMMUNOGLOBULIN-LIKE DOMAINS, NATURE 308: 37 (1984). · DOI
- MOUNT, S.M., A CATALOG OF SPLICE JUNCTION SEQUENCES, NUCLEIC ACIDS RESEARCH 10: 459 (1982). · DOI
- NAWA, H, TISSUE-SPECIFIC GENERATION OF 2 PRE-PROTACHYKININ MESSENGER-RNAS FROM ONE GENE BY ALTERNATIVE RNA SPLICING, NATURE 312: 729 (1984). · DOI
- RALL, L.B., MOUSE PREPRO-EPIDERMAL GROWTH-FACTOR SYNTHESIS BY THE KIDNEY AND OTHER TISSUES, NATURE 313: 228 (1985). · DOI
- RUSSELL, D.W., DOMAIN MAP OF THE LDL RECEPTOR - SEQUENCE HOMOLOGY WITH THE EPIDERMAL GROWTH-FACTOR PRECURSOR, CELL 37: 577 (1984). · DOI · Paper page
- RUSSELL, D.W., CDNA CLONING OF THE BOVINE LOW-DENSITY LIPOPROTEIN RECEPTOR - FEEDBACK-REGULATION OF A RECEPTOR MESSENGER-RNA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80: 7501 (1983).
- 10.1073/pnas.74.12.5463 · DOI · Paper page
- SCHNEIDER, C, PRIMARY STRUCTURE OF HUMAN TRANSFERRIN RECEPTOR DEDUCED FROM THE MESSENGER-RNA SEQUENCE, NATURE 311: 675 (1984).
- 10.1126/science.6602382 · DOI
- SHENK, T, Transcriptional Control Regions: Nucleotide Sequence Requirements for Initiation by RNA Polymerase II and III, CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY 93: 25 (1981).
- STANLEY, K.K., THE SEQUENCE AND TOPOLOGY OF HUMAN-COMPLEMENT COMPONENT C9, EMBO JOURNAL 4: 375 (1985). · DOI
- STUART, G.W., A 12-BASE-PAIR DNA MOTIF THAT IS REPEATED SEVERAL TIMES IN METALLOTHIONEIN GENE PROMOTERS CONFERS METAL REGULATION TO A HETEROLOGOUS GENE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 7318 (1984).
- 10.1126/science.3873704 · DOI
- TOLLESHAUG, H, POSTTRANSLATIONAL PROCESSING OF THE LDL RECEPTOR AND ITS GENETIC DISRUPTION IN FAMILIAL HYPERCHOLESTEROLEMIA, CELL 30: 715 (1982). · DOI · Paper page
- ULLRICH, A, HUMAN EPIDERMAL GROWTH-FACTOR RECEPTOR CDNA SEQUENCE AND ABERRANT EXPRESSION OF THE AMPLIFIED GENE IN A431 EPIDERMOID CARCINOMA-CELLS, NATURE 309: 418 (1984). · DOI
- YAMAMOTO, T, THE HUMAN LDL RECEPTOR - A CYSTEINE-RICH PROTEIN WITH MULTIPLE ALU SEQUENCES IN ITS MESSENGER-RNA, CELL 39: 27 (1984). · DOI · Paper page
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Metadata
- Authors
- Südhof, T. C., Goldstein, J. L., Brown, M. S., & Russell, D. W.
- Affiliations
- Department of Molecular Genetics, University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas 75235.
- Venue
- Science
- Published
- 1985-05-17
- Volume
- 228
- Issue
- 4701
- Pages
- 815-822
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 611
- References
- 1
- Language
- en
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