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FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
Abstract
Fibroblast growth factor 5 (FGF5) is a secreted signaling protein. Mice homozygous for a predicted null allele of the Fgf5 gene, fgf5neo, produced by gene targeting in embryonic stem cells, have abnormally long hair. This phenotype appears identical to that of mice homozygous for the spontaneous mutation angora (go). The fgf5neo and go mutations fail to complement one another, and exon 1 of Fgf5 is deleted in DNA from go homozygotes, demonstrating that go is a mutant allele of Fgf5. Expression of Fgf5 is detected in hair follicles from wild-type mice and is localized to the outer root sheath during the anagen VI phase of the hair growth cycle. These findings provide evidence that FGF5 functions as an inhibitor of hair elongation, thus identifying a molecule whose normal function is apparently to regulate one step in the progression of the follicle through the hair growth cycle.
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“Remarkably, within several weeks of doxycycline treatment, the coats of i-TERT mice were significantly altered, reminiscent of mice with known mutations that affect hair follicle cycling26,27 (Fig 1e).”
From Conditional telomerase induction causes proliferation of hair follicle stem cells (2005) · cites this paper as [26]
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Metadata
- Authors
- Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 78
- Issue
- 6
- Pages
- 1017-1025
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2056016311
- Cited by
- 589
- References
- 67
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 9 · 2023: 21 · 2022: 24 · 2021: 15 · 2020: 23 · 2019: 15 · 2018: 10 · 2017: 21 · 2016: 22 · 2015: 12 · 2014: 18 · 2013: 16 · 2012: 20
- FWCI
- 35.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Lucille P. Markey Charitable Trust (8814)
- National Institutes of Health (CA 09043, PO1 HL 43821, ROl HD22731)
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Dentistry › General Dentistry › dental development and anomalies
- Keywords
- FGF5, hair cycle, anagen, outer root sheath, hair follicle, gene targeting, spontaneous mutation, complementation
- MeSH terms
- Alleles, Animals, Base Sequence, Fibroblast Growth Factors, Genetic Complementation Test, Hair, Homozygote, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Mutant Strains, Molecular Sequence Data, Phenotype, RNA, Messenger, Tissue Distribution, Transforming Growth Factor alpha, In Situ Hybridization, Mice, Knockout, Mice, Fibroblast Growth Factor 5
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