Götz, Jürgen

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B. C., Christie, M. J., Napier, I. A., et al. (2010) · Cell

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 1,821

Animal models of Alzheimer's disease and frontotemporal dementia

Götz, J., & Ittner, L. M. (2008) · Nature Reviews Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 676

Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

Rhein, V., Song, X., Wiesner, A., Ittner, L. M., Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Dröse, S., Brandt, U., et al. (2009) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 655

The blood-brain barrier: Physiology and strategies for drug delivery

Pandit, R., Chen, L., & Götz, J. (2020) · Advanced Drug Delivery Reviews

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 651

FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R. (1994) · Cell

Hair Growth and DisordersFibroblast Growth Factor Research

Cited by 589

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

Leinenga, G., & Götz, J. (2015) · Science Translational Medicine

Alzheimer's disease research and treatmentsUltrasound and Hyperthermia Applications

Cited by 498

Tau filament formation in transgenic mice expressing P301L tau

Götz, J., Chen, F., Barmettler, R., & Nitsch, R. M. (2001) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 495

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice

David, D. C., Hauptmann, S., Scherping, I., Schuessel, K., Keil, U., Rizzu, P., Ravid, R., Dröse, S., Brandt, U., Müller, W. E., et al. (2005) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 447

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

DuBoff, B., Götz, J., & Feany, M. B. (2012) · Neuron

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 377

Tau Aggregation and Its Interplay with Amyloid-β

Nisbet, R. M., Polanco, J.-C., Ittner, L. M., & Götz, J. (2015) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 359

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer’s disease models

van Eersel, J., Ke, Y. D., Liu, X., Delerue, F., Kril, J. J., Götz, J., & Ittner, L. M. (2010) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 284

Molecular Pathogenesis of the Tauopathies

Götz, J., Halliday, G., & Nisbet, R. M. (2019) · Annual Review of Pathology: Mechanisms of Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 276

Tau-based therapies in neurodegeneration: opportunities and challenges

Li, C., & Götz, J. (2017) · Nature Reviews Drug Discovery

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 272

Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

Cummins, N., Tweedie, A., Zuryn, S., Bertran‐Gonzalez, J., & Götz, J. (2019) · The EMBO Journal

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 267

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα

Götz, J., Probst, A., Ehler, E., Hemmings, B., & Kues, W. (1998) · Proceedings of the National Academy of Sciences

Protein Tyrosine PhosphatasesDevelopmental Biology and Gene Regulation

Cited by 220

Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β

Schonrock, N., Ke, Y. D., Humphreys, D., Staufenbiel, M., Ittner, L. M., Preiss, T., & Götz, J. (2010) · PLoS ONE

Alzheimer's disease research and treatmentsMicroRNA in disease regulation

Cited by 211

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice

Kins, S., Crameri, A., Evans, D. R. H., Hemmings, B. A., Nitsch, R. M., & Götz, J. (2001) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 203

Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model

Nisbet, R. M., Van der Jeugd, A., Leinenga, G., Evans, H. T., Janowicz, P. W., & Götz, J. (2017) · Brain

Alzheimer's disease research and treatmentsUltrasound and Hyperthermia Applications

Cited by 187

Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity

Eckert, A., Schmitt, K., & Götz, J. (2011) · Alzheimer's Research & Therapy

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 177

Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

Kins, S., Kurosinski, P., Nitsch, R. M., & Götz, J. (2003) · The American Journal of Pathology

Alzheimer's disease research and treatmentsProtein Kinase Regulation and GTPase Signaling

Cited by 155

Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice

Bi, M., Ittner, A., Ke, Y. D., Götz, J., & Ittner, L. M. (2011) · PLoS ONE

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 153

Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.

van Eersel, J., Ke, Y. D., Gladbach, A., Bi, M., Götz, J., Kril, J. J., & Ittner, L. M. (2011) · PLoS ONE

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 130

Connecting the dots between tau dysfunction and neurodegeneration

Frost, B., Götz, J., & Feany, M. B. (2015) · Trends in Cell Biology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 124

Mice lacking phosphatase PP2A subunit PR61/B’δ ( Ppp2r5d ) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β

Louis, J. V., Martens, E., Borghgraef, P., Lambrecht, C., Sents, W., Longin, S., Zwaenepoel, K., Pijnenborg, R., Landrieu, I., Lippens, G., et al. (2011) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsProtein Kinase Regulation and GTPase Signaling

Cited by 112