The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo
Open accessAbstract
HNF-3 beta, a transcription factor of the winged-helix family, is expressed in embryonic and adult endoderm and also in midline cells of the node, notochord, and floor plate in mouse embryos. To define the function of HNF-3 beta, a targeted mutation in the HNF-3 beta locus was generated by homologous recombination in embryonic stem cells. Mice lacking HNF-3 beta die by embryonic day (E) 10-11. Mutant embryos examined from E6.5 to E9.5 do not form a distinct node and lack a notochord. In addition, mutant embryos show marked defects in the organization of somites and neural tube that may result from the absence of the notochord. The neural tube of mutant embryos exhibits overt anteroposterior polarity but lacks a floor plate and motor neurons. Endodermal cells are present but fail to form a gut tube in mutant embryos. These studies indicate that HNF-3 beta has an essential role in the development of axial mesoderm in mouse embryos.
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Cites
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Cited by
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Dahmane, N., & Altaba, A. R. I. (1999) · Development · doi:10.1242/dev.126.14.3089 · Cited by 907
Requirement for LIml in head-organizer function
Shawlot, W., & Behringer, R. R. (1995) · Nature · doi:10.1038/374425a0 · Cited by 805
Axis Development and Early Asymmetry in Mammals
Beddington, R. S. P., & Robertson, E. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80560-7 · Cited by 756
Metadata
- Authors
- Weinstein, D. C., Ruiz i Altaba, A., Chen, W. S., Hoodless, P., Prezioso, V. R., Jessell, T. M., & Darnell, J. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1994-08
- Volume
- 78
- Issue
- 4
- Pages
- 575-588
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2009624062
- Cited by
- 783
- References
- 84
- FWCI
- 19.12
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo. https://app.cochat.ai/papers/10.1016/0092-8674(94)90523-1
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- Weinstein, D. C., Ruiz i Altaba, A., Chen, W. S., Hoodless, P., Prezioso, V. R., Jessell, T. M., & Darnell, J. E. (1994). The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo. Cell. https://doi.org/10.1016/0092-8674(94)90523-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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