The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously
Open accessAbstract
Mutations in the C. elegans gene lin-44 lead to reversals in the polarity of certain asymmetric cell divisions. We have discovered that lin-44 is a member of the Wnt family of genes, which encode secretory glycoproteins implicated in intercellular signaling. Both in situ hybridization experiments using lin-44 transcripts and experiments using reporter constructs designed to mimic patterns of lin-44 expression indicate that lin-44 is expressed in hypodermal cells at the tip of the tail and posterior to the cells with polarities affected by lin-44 mutations. Our mosaic analysis indicates that lin-44 acts cell nonautonomously. We propose that LIN-44 protein is secreted by tail hypodermal cells and affects the polarity of asymmetric cell divisions that occur more anteriorly in the tail.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
T-cell polarity is controlled by LIN-44 (Wnt), LIN-17 (Frizzled receptor), and POP-1.
“T-cell polarity is controlled by LIN-44 (Wnt), LIN-17 (Frizzled receptor), and POP-1 (7, 8, 9, 26).”
Cites
Herman, M. A., & Horvitz, H. R. (1994) · Development · doi:10.1242/dev.120.5.1035 · Cited by 120 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Boutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81226-x · Cited by 801 · see citing works
Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764 · see citing works
Wnt signaling: complexity at the surface
Cadigan, K. M., & Liu, Y. I. (2006) · Journal of Cell Science · doi:10.1242/jcs.02826 · Cited by 486 · see citing works
Analysis of Dishevelled signalling pathways during Xenopus development
Sokol, S. Y. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00750-6 · Cited by 406 · see citing works
Dishevelled: at the crossroads of divergent intracellular signaling pathways
Boutros, M., & Mlodzik, M. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00046-5 · Cited by 275 · see citing works
Wnt signaling in neural circuit assembly
Salinas, P. C., & Zou, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125649 · Cited by 274 · see citing works
Ishitani, T., Ninomiya-Tsuji, J., & Matsumoto, K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1379-1389.2003 · Cited by 212 · see citing works
- Authors
- Herman, M. A., Vassilieva, L. L., Horvitz, H. R., Shaw, J. E., & Herman, R. K.
- Affiliations
- University of Minnesota (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-10
- Volume
- 83
- Issue
- 1
- Pages
- 101-110
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2058449530
- Cited by
- 199
- References
- 1
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 8 · 2012: 6
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd022163-03, 2r01gm024943-09)
- National Institute of General Medical Sciences (R01GM022387, GM24943, GM22387)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 22163)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- Wnt proteins, asymmetric cell division, cell polarity, non-cell-autonomous signaling, hypodermal cells, secreted glycoprotein, intercellular communication, Caenorhabditis elegans, mosaic analysis, gene expression patterns
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cell Division, Drosophila melanogaster, Gene Expression Regulation, Multigene Family, Glycoproteins, Molecular Sequence Data, Mosaicism, Phenotype, Proto-Oncogene Proteins, Recombinant Fusion Proteins, Disorders of Sex Development, Tail, Signal Transduction, Helminth Proteins, Consensus Sequence, Sequence Alignment, Cell Polarity, Caenorhabditis elegans, Sequence Homology, Amino Acid, In Situ Hybridization, Genes, Reporter, DNA, Complementary, Chromosomes, Artificial, Yeast, Cell Lineage, Drosophila Proteins, Caenorhabditis elegans Proteins, Wnt1 Protein, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
