Cited by 120Developmental Biology and Gene RegulationCellular Mechanics and InteractionsMicrotubule and mitosis dynamics

The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions

Herman, Michael A., Horvitz, H. Robert·1994·Development

Abstract

The generation and orientation of cellular and organismic polarity are fundamental aspects of development. Mutations in the gene lin-44 of the nematode Caenorhabditis elegans reverse both the relative positions of specific sister cells and the apparent polarities of these cells. Thus, lin-44 mutants appear to generate polar cells but to misorient these cells along the body axis of the animal. We postulate that lin-44 acts to specify the orientation of polar cells.

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Crossref · 10.1242/dev.120.5.1035

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Authors
Herman, M. A., & Horvitz, H. R.
Affiliations
Howard Hughes Medical Institute (US)
Venue
Development
Published
1994-05-01
Volume
120
Issue
5
Pages
1035-1047
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W2099515731
Cited by
120
References
48
Citations by year
2026: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
1.39
Type
journal article
Language
en
Open access
closed
Locations
  • Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (R01GM022387, GM 24663, GM22387, GM07287, T32GM007287)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords
asymmetric cell division, cell polarity, body axis, Caenorhabditis elegans, cell fate specification
MeSH terms
Animals, Cell Differentiation, Cell Division, Mutation, Cell Polarity, Caenorhabditis elegans, Genes, Helminth

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