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Contactin Orchestrates Assembly of the Septate-like Junctions at the Paranode in Myelinated Peripheral Nerve

Boyle, Mary E.T., Berglund, Erik O., Murai, Keith K., Weber, Lynne, Peles, Elior, Ranscht, Barbara·2001·Neuron
DOI 10.1016/s0896-6273(01)00296-3
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Abstract

Rapid nerve impulse conduction depends on specialized membrane domains in myelinated nerve, the node of Ranvier, the paranode, and the myelinated internodal region. We report that GPI-linked contactin enables the formation of the paranodal septate-like axo-glial junctions in myelinated peripheral nerve. Contactin clusters at the paranodal axolemma during Schwann cell myelination. Ablation of contactin in mutant mice disrupts junctional attachment at the paranode and reduces nerve conduction velocity 3-fold. The mutation impedes intracellular transport and surface expression of Caspr and leaves NF155 on apposing paranodal myelin disengaged. The contactin mutation does not affect sodium channel clustering at the nodes of Ranvier but alters the location of the Shaker-type Kv1.1 and Kv1.2 potassium channels. Thus, contactin is a crucial part in the machinery that controls junctional attachment at the paranode and ultimately the physiology of myelinated nerve.

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Metadata

Authors
Boyle, M. E. T., Berglund, E. O., Murai, K. K., Weber, L., Peles, E., & Ranscht, B.
Venue
Neuron
Publisher
Elsevier BV
Published
2001-05
Volume
30
Issue
2
Pages
385-397
ISSN
0896-6273
DOI
10.1016/s0896-6273(01)00296-3
Cited by
452
References
3
Language
en
Licence

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