CoChat
Sign Up
Cited by 437Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and related disorders

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Association of sleep-wake habits in older people with changes in output of circadian pacemaker

Czeisler, C.A, Dumont, M, Duffy, J.F, Steinberg, J.D, Richardson, G.S, Brown, E.N, Sánchez, R, Ríos, C.D, Ronda, J.M·1992·The Lancet
DOI 10.1016/0140-6736(92)92817-y
Open this paper in CoChat — free account

Abstract

Many elderly people complain of disturbed sleep patterns but there is not evidence that the need to sleep decreases with age; it seems rather that the timing and consolidation of sleep change. We tried to find out whether there is a concurrent change in the output of the circadian pacemaker with age. The phase and amplitude of the pacemaker's output were assessed by continuous measurement of the core body temperature during 40 h of sustained wakefulness under constant behavioural and environmental conditions. 27 young men (18-31 years) were compared with 21 older people (65-85 years; 11 men, 10 women); all were healthy and without sleep complaints. The mean amplitude of the endogenous circadian temperature oscillation (ECA) was 40% greater in young men than in the older group. Older men had a lower mean temperature ECA than older women. The minimum of the endogenous phase of the circadian temperature oscillation (ECP) occurred 1 h 52 min earlier in the older than in the young group. Customary bedtimes and waketimes were also earlier in the older group, as was their daily alertness peak. There was a close correlation between habitual waketime and temperature ECP in young men, which may lose precision with age, especially among women. These findings provide evidence for systematic age-related changes in the output of the human circadian pacemaker. We suggest that these changes may underlie the common complaints of sleep disturbance among elderly people. These changes could reflect the observed age-related deterioration of the hypothalamic nuclei that drive mammalian circadian rhythms.

Overview

Integrity signals

Registry

Crossref · 10.1016/0140-6736(92)92817-y

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 25 references

Research works printed but not linked: 2

  1. Dumont, 1990, Endogenous circadian phase and amplitude in elderly patients with a complaint of insomnia, Sleep Res, 19, 217
  2. Campbell, 1991, Bright light treatment of sleep disturbance in older subjects, Sleep Res, 20, 448

Cited by

Sorted by citations

Items 401–436 of 436

Related

See all

Metadata

Authors
Czeisler, C. A., Dumont, M., Duffy, J. F., Steinberg, J. D., Richardson, G. S., Brown, E. N., Sánchez, R., Ríos, C. D., & Ronda, J. M.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Czeisler, C.A
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
1992-10
Volume
340
Issue
8825
Pages
933-936
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/0140-6736(92)92817-y
OpenAlex
W2052495561
Cited by
437
References
25
Citations by year
2026: 3 · 2025: 17 · 2024: 9 · 2023: 13 · 2022: 12 · 2021: 13 · 2020: 8 · 2019: 10 · 2018: 12 · 2017: 16 · 2016: 11 · 2015: 10 · 2014: 9 · 2013: 11 · 2012: 9
FWCI
8.02
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R01AG006072, 1-RO1-AG06072, 1-P01-AG-09975, P01AG009975)
  • National Institute of Mental Health (H5-ROI-MH45130)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
circadian pacemaker, aging, core body temperature, circadian rhythm, alertness, hypothalamic nuclei, sex differences
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Body Temperature, Circadian Rhythm, Female, Humans, Male, Sex Factors, Sleep Deprivation, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review