Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle

Czeisler, Charles A.; Allan, James S.; Strogatz, Steven H.; Ronda, Joseph M.; Sánchez, Ramiro; Ríos, C. David; Freitag, Walter O.; Richardson, Gary S.; Kronauer, Richard E.

doi:10.1126/science.3726555

Cited by 770Circadian rhythm and melatoninSleep and Work-Related FatigueImpact of Light on Environment and Health

Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle

Czeisler, Charles A., Allan, James S., Strogatz, Steven H., Ronda, Joseph M., Sánchez, Ramiro, Ríos, C. David, Freitag, Walter O., Richardson, Gary S. +1 more·1986·Science

DOI 10.1126/science.3726555

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Abstract

Human circadian rhythms were once thought to be insensitive to light, with synchronization to the 24-hour day accomplished either through social contacts or the sleep-wake schedule. Yet the demonstration of an intensity-dependent neuroendocrine response to bright light has led to renewed consideration of light as a possible synchronizer of the human circadian pacemaker. In a laboratory study, the output of the circadian pacemaker of an elderly woman was monitored before and after exposure to 4 hours of bright light for seven consecutive evenings, and before and after a control study in ordinary room light while her sleep-wake schedule and social contacts remained unchanged. The exposure to bright light in the evening induced a 6-hour delay shift of her circadian pacemaker, as indicated by recordings of body temperature and cortisol secretion. The unexpected magnitude, rapidity, and stability of the shift challenge existing concepts regarding circadian phase-resetting capacity in man and suggest that exposure to bright light can indeed reset the human circadian pacemaker, which controls daily variations in physiologic, behavioral, and cognitive function.

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Authors: Czeisler, C. A., Allan, J. S., Strogatz, S. H., Ronda, J. M., Sánchez, R., Ríos, C. D., Freitag, W. O., Richardson, G. S., & Kronauer, R. E.
Affiliations: Brigham and Women's Hospital (US)
Harvard University (US)
Neuroendocrinology Laboratory, Division of Endocrinology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
ORCID: Czeisler, Charles A.
Allan, James S.
Strogatz, Steven H.
Ronda, Joseph M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1986-08-08
Volume: 233
Issue: 4764
Pages: 667-671
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.3726555
OpenAlex: W2003623977
Cited by: 770
References: 28
Citations by year: 2026: 12 · 2025: 17 · 2024: 15 · 2023: 24 · 2022: 25 · 2021: 14 · 2020: 25 · 2019: 23 · 2018: 19 · 2017: 23 · 2016: 27 · 2015: 17 · 2014: 27 · 2013: 19 · 2012: 27
FWCI: 12.02
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hd020174-03)
U.S. Public Health Service (AFOSR-83-0309)
National Institute on Aging (1 R01-AG-04912-02)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (1 R01-HD-20174-01)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
Keywords: circadian pacemaker, phase resetting, bright light exposure, circadian synchronization, circadian phase shift, body temperature, cortisol secretion, sleep-wake cycle, older women
MeSH terms: Aged, Body Temperature, Circadian Rhythm, Female, Humans, Hydrocortisone, Light, Sleep

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Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle

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