The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A physiological model of glucose-insulin interaction in type 1 diabetes mellitus
Abstract
A clinical model of glucose-insulin interaction in insulin-dependent diabetes mellitus has been developed for patient and medical staff education. The model attempts to reflect the underlying (patho)physiology of insulin action and carbohydrate absorption in quantitative terms such as insulin sensitivity, volume of glucose and insulin distribution and maximal rate of gastric emptying. The model's predictions also allow a 24 h simulation of patient blood glucose profiles to be generated. A description of the model is provided and its operation illustrated by clinical case studies of insulin-treated diabetic patients. The possible use of the model as a tool for automated insulin dosage adjustment is explored.
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Citations
Cites
Quantitative estimation of insulin sensitivity.
Bergman, R. N., Ider, Y. Z., Bowden, C. R., & Cobelli, C. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.236.6.e667 · Cited by 1,874
Cited by
Meal Simulation Model of the Glucose-Insulin System
Dalla Man, C., Rizza, R. A., & Cobelli, C. (2007) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2007.893506 · Cited by 955
Artificial Pancreas: Past, Present, Future
Cobelli, C., Renard, E., & Kovatchev, B. (2011) · Diabetes · doi:10.2337/db11-0654 · Cited by 600
Diabetes: Models, Signals, and Control
Cobelli, C., Dalla Man, C., Sparacino, G., Magni, L., De Nicolao, G., & Kovatchev, B. P. (2009) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2009.2036073 · Cited by 511
Woldaregay, A. Z., Årsand, E., Walderhaug, S., Albers, D., Mamykina, L., Botsis, T., & Hartvigsen, G. (2019) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2019.07.007 · Cited by 358
GIM, Simulation Software of Meal Glucose–Insulin Model
Dalla Man, C., Raimondo, D. M., Rizza, R. A., & Cobelli, C. (2007) · Journal of Diabetes Science and Technology · doi:10.1177/193229680700100303 · Cited by 253
Metadata
- Authors
- Lehmann, E. D., & Deutsch, T.
- Venue
- Journal of Biomedical Engineering
- Publisher
- IOP Publishing
- Published
- 1992-05-01
- Volume
- 14
- Issue
- 3
- Pages
- 235-242
- ISSN
- 0141-5425 (ISSN-L)
- OpenAlex
- W2041058086
- Cited by
- 401
- References
- 1
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lehmann, E. D., & Deutsch, T. (1992). A physiological model of glucose-insulin interaction in type 1 diabetes mellitus. Journal of Biomedical Engineering. https://doi.org/10.1016/0141-5425(92)90058-s
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
