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Cited by 57Pregnancy and preeclampsia studiesHigh Altitude and HypoxiaReproductive System and Pregnancy

On the factors which contribute to thinning of the villous membrane in human placentae at high altitude. II. An increase in the degree of peripheralization of fetal capillaries

Jackson, Moira R., Mayhew, T.M., Haas, J.D.·1988·Placenta
DOI 10.1016/0143-4004(88)90068-9
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Abstract

The contribution made by fetal capillary peripheralization to the thinning of the villous membrane seen in human placentae from high-altitude pregnancies is examined by stereological methods. Variables characterizing the shape of the villous core and the spatial relationships between trophoblast and capillaries are quantified. They shed light on the relative importance of dynamic versus mechanistic processes of villous membrane attenuation. Highland villi differ from lowland villi in several ways. On average, they possess a thinner barrier due to closer approximation of capillaries to overlying trophoblast; in consequence, the villous core is more irregular in outline and its surface (that of the inner aspect of the trophoblast) exceeds in area that of the outer aspect of the trophoblast. These results suggest that the dynamic process (protoplasmic streaming within syncytiotrophoblast) cannot alone explain thinning of the villous membrane. A mechanistic process (capillary peripheralization and obtrusion into the trophoblastic epithelium) is sufficient to account for the differences observed, although the possibility that both processes operate concurrently cannot be discounted. This report completes a study into factors contributing to villous membrane thinning at high altitude.

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Crossref · 10.1016/0143-4004(88)90068-9

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  • Studies show no consistent effect of chronic hypoxia on placental weight or size, with increases, decreases and no change depending on the study and/or population.

    “These show no consistent effect of chronic hypoxia on placental weight or size with increases, decreases and no change depending on the study and/or population.”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [276]

  • There is thinning of the interhemal membrane in the human placenta at high altitude.

    “In addition, there is thinning of the interhemal membrane in the human placenta at high altitude (276, 366, 458).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [276]

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Authors
Jackson, M. R., Mayhew, T. M., & Haas, J. D.
Affiliations
  • University of Aberdeen (GB)
  • Cornell University (US)
Corresponding author
Jackson, Moira R.
ORCID
Haas, J.D.
Venue
Placenta
Publisher
Elsevier BV
Published
1988-01
Volume
9
Issue
1
Pages
9-18
ISSN
0143-4004 (ISSN-L)
DOI
10.1016/0143-4004(88)90068-9
OpenAlex
W2056156426
Cited by
57
References
19
Citations by year
2026: 1 · 2022: 3 · 2021: 2 · 2018: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2012: 3
FWCI
5.47
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Placenta (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
high altitude, placental barrier, trophoblast, syncytiotrophoblast, cytoplasmic streaming, stereology, high-altitude pregnancy
MeSH terms
Altitude, Analysis of Variance, Bolivia, Capillaries, Chorionic Villi, Ethnicity, Female, Humans, Models, Biological, Pregnancy, Sex Factors, Trophoblasts

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