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Cited by 83Pregnancy and preeclampsia studiesReproductive System and PregnancyBirth, Development, and Health

Microscopical morphology of the human placenta and its effects on oxygen diffusion: a morphometric model

Mayhew, T.M., Jackson, Moira R., Haas, J.D.·1986·Placenta
DOI 10.1016/s0143-4004(86)80003-0
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Abstract

A combination of stereological and physicochemical data was used to estimate the oxygen-diffusing capacity of the human term placenta. The effects on this morphometric diffusing capacity of isolated changes in placental structure were investigated by permitting volumes, surface areas and harmonic mean diffusion distances to deviate from normal baseline (term) values. Diffusion performance could be monitored effectively by estimating only three structural quantities. The most influential variable was the harmonic mean thickness of the villous membrane followed by the surface areas of villi and of fetal capillaries. Blood space volumes and plasma diffusion distances had negligible effects on diffusing capacity. Conclusions are discussed in the context of published findings on changes in placental anatomy which occur during gestation, abnormal pregnancies and pregnancies at high altitude.

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Crossref · 10.1016/s0143-4004(86)80003-0

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  • Under limiting conditions such as pregnancy at high altitude, changes in surface area or membrane thickness may be adaptive responses to facilitate exchange.

    “However, under limiting conditions, such as pregnancy at high altitude, changes in surface area or membrane thickness may be considered adaptive responses to facilitate exchange (275, 369, 458).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [369]

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Authors
Mayhew, T. M., Jackson, M. R., & Haas, J. D.
Affiliations
  • University of Aberdeen (GB)
  • Cornell University (US)
Corresponding author
Mayhew, T.M.
ORCID
Haas, J.D.
Venue
Placenta
Publisher
Elsevier BV
Published
1986-03
Volume
7
Issue
2
Pages
121-131
ISSN
0143-4004 (ISSN-L)
DOI
10.1016/s0143-4004(86)80003-0
OpenAlex
W2091570559
Cited by
83
References
34
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2012: 5
FWCI
6.94
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Placenta (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • Anatomical Society
  • Leverhulme Trust
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
human placenta, oxygen diffusion, diffusing capacity for carbon monoxide, placental morphology, chorionic villi, fetal capillaries, placental surface area, stereology, morphometric model, gestational changes, abnormal pregnancy, high-altitude pregnancy
MeSH terms
Chorionic Villi, Diffusion, Female, Humans, Models, Biological, Oxygen, Placenta, Pregnancy

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