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Cited by 351Neuropeptides and Animal PhysiologyStress Responses and CortisolNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 249 of the 249 references it cites were found in a registry or an index.

The role of endorphins in stress: Evidence and speculations

Amir, Shimon, Brown, Zavie W., Amit, Zalman·1980·Neuroscience & Biobehavioral Reviews
DOI 10.1016/0149-7634(80)90027-5
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Abstract

Several lines of evidence suggest that the endogenous opioid peptides endorphins may play a role in the defensive response of the organism to stress. The present paper summarizes these findings as well as evidence linking endorphins to the anterior pituitary polypeptide hormone adrenocorticotropin (ACTH). Evidence is presented that endorphins may function as trophic hormones in peripheral target organs such as the adrenal medulla and the pancreas. As such they may be part of the physiological mechanisms that mediate adrenaline and glucagon release in response to stress. Endorphins (enkephalins) are also suggested to play a role in the control of the pituitary gland during stress. In such capacity they may act as hormone-releasing or inhibiting factors. Finally, endorphins appear to play a role in the behavioral concomitants of stress. In such capacity endorphins are suggested to function as modulators of neural systems that mediate the elaboration and expression of the reactive/affective components of stress. Speculations on the mode of interaction between endorphins and ACTH in the global response to stress are discussed.

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Crossref · 10.1016/0149-7634(80)90027-5

Cites

249 of 249 references verified0 citation errors · 0 not checkable

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Citations

Cites

Items 201–249 of 249

Research works printed but not linked: 8

  1. Criswell, 1979, Partial antagonism of stress induced analgesia by ACTH pretreatment, Soc. Neurosci. Abstr., 5, 1768
  2. Di Guilio, 1978, On the enkephalin content of sympathetic ganglia, The Pharmacologist, 20, 167
  3. French, 1978, Morphine or stress induced increases of plasma b-endorphin and prolactin are prevented by dexamethason pretreatment, Soc. Neurosci. Abstr., 4, 1285
  4. Kelly, D. D. and R. J. Bodnar. Stress induced analgesia: A behavioral analysis. Neurosci. Biocbehav. Res., in press.
  5. Kvetnansky, 1974, Transsynaptic and humoral regulation of adrenal cathecolamine synthesis in stress, Biochem. Pharmac., 23, 160
  6. Mayer, 1976, Acupuncture analgesia: Evidence for activation of a pain inhibitory system as a mechanism of action, Vol. 1, 751
  7. Selye, 1950, Stress. The physiology and pathology of exposure to stress, Acta Med.
  8. Watson, 1979, b-endorphin and b-MSH: Common cells of origin and binding properties, Soc. neurosci. Abstr., 5, 1840

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Metadata

Authors
Amir, S., Brown, Z. W., & Amit, Z.
Affiliations
Concordia University (CA)
ORCID
Amir, Shimon
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
1980-03
Volume
4
Issue
1
Pages
77-86
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/0149-7634(80)90027-5
OpenAlex
W2076340827
Cited by
351
References
249
Citations by year
2026: 1 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 4
FWCI
9.62
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
endorphins, enkephalin, stress response, ACTH, anterior pituitary, trophic hormones, adrenal medulla, pancreas, adrenaline secretion, glucagon secretion, pituitary regulation, behavioral stress response, opioid peptides
MeSH terms
Adaptation, Physiological, Adrenal Medulla, Adrenocorticotropic Hormone, Animals, Chemistry, Emotions, Endorphins, Epinephrine, Glucagon, Humans, Hypothalamo-Hypophyseal System, Insulin, Islets of Langerhans, Naloxone, Pain, Pituitary Gland, Pituitary-Adrenal System, Receptors, Opioid, Stress, Physiological, Stress, Psychological, Vasopressins, Rats, Chemical Phenomena

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