Chronic stress sensitizes frontal cortex dopamine release in response to a subsequent novel stressor: reversal by naloxone
Abstract
The present study examined the influence of an early chronic variable stress procedure with or without concurrent naloxone administration at different doses (1, 2 or 3 mg/kg, i.p.) on stress (restraint)-induced dopamine release in the frontal cortex in vivo. A higher increase in cortical dopamine release in response to a subsequent restraint event was observed in chronically stressed rats as compared with those without chronic stress exposure. Naloxone pretreatment normalized this sensitized response only at the higher dose (3 mg/kg, i.p.). The present results indicate that cortical dopamine response to a novel and uncontrollable stressor sensitizes after exposure to a chronic variable stress procedure and that an endogenous opiate mechanism, presumably activated during chronic stress, may be involved in the development of such a sensitization process.
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The physiological response to stress, involving elevated corticotropin-releasing factor (CRF), recruits activity in dopaminergic pathways and elevates dopaminergic activity.
“There is also evidence to suggest that the physiological response to stress, involving elevated corticotropin-releasing factor (CRF), a hormone highly implicated in the stress response, recruits activity in dopaminergic pathways and elevates dopaminergic activity (Berridge, 2010; Cuadra, Zurita, Lacerra, & Molina, 1999; Dallman, 2010; Peciña, Schulkin, & Berridge, 2006).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Cuadra, Zurita, Lacerra, & Molina, 1999
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- Authors
- Cuadra, G., Zurita, A., Lacerra, C., & Molina, V.
- Affiliations
- Universidad Nacional de Córdoba (AR)
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 1999-02
- Volume
- 48
- Issue
- 3
- Pages
- 303-308
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2049925866
- Cited by
- 63
- References
- 40
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- chronic stress, variable stress, naloxone, dopamine release, frontal cortex, restraint stress, stress sensitization, endogenous opioids, opioid antagonism, uncontrollable stress, rats
- MeSH terms
- Animals, Chronic Disease, Dopamine, Frontal Lobe, Male, Naloxone, Narcotic Antagonists, Restraint, Physical, Stress, Physiological, Rats, Wistar, Microdialysis, Opioid Peptides, Rats
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