The spontaneously hypertensive rat as an animal model of attention-deficit hyperactivity disorder: effects of methylphenidate on exploratory behavior.
Abstract
Spontaneously hypertensive rats (SHR) show a pervasive hyperactivity in several paradigms. Thus, these rats may be used as an animal model of childhood hyperactivity also called Attention-Deficit Hyperactivity Disorder. This disorder is frequently treated with psychomotor stimulant drugs, but little is known about the effects of such drugs on behavior. The present study investigated the behavioral effects of 1-24 mg/kg methylphenidate (Ritalin) on the exploratory behavior of male SHR and Wistar-Kyoto control rats (WKY) in a two-compartment free-exploration open field. Except following very high doses. SHR spent most of the session time in the field while WKY stayed in the home cage. Low and medium doses were followed by increased activity in the field for SHR and increased activity in the cage for WKY. The response-stimulatory effects of low to medium doses of methylphenidate are less in SHR than in WKY. Starting at medium doses, activity decreased and stereotyped behavior increased progressively by increasing dose. Locomotor activity in the field decreased following lower doses than locomotor activity in the cage, and vertical activity (rearing) was reduced by lower doses than horizontal activity (crossing). The following conclusions were drawn. (i) There is no "paradoxical" inhibition of SHR hyperactivity following methylphenidate. On the contrary, SHR activity is in fact stimulated, albeit to a lesser degree than that of WKY. (ii) The stimulatory effects of low to medium d…
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The findings of SHR operant and motor hyperactivity replicate previous research evaluating the use of the SHR strain as a model of ADHD.
“These findings of SHR operant and motor hyperactivity replicate previous research evaluating the use of the SHR strain as a model of ADHD (Wultz et al., 1990; Hill et al., 2012).”
From The Effects of Methylphenidate on Goal-directed Behavior in a Rat Model of ADHD (2015) · cites this paper as Wultz et al., 1990
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Robbins, T. W., & Sahakian, B. J. (1979) · Neuropharmacology · doi:10.1016/0028-3908(79)90157-6 · Cited by 170 · see citing works
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Sagvolden, T. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00058-5 · Cited by 525 · see citing works
Self-citationRodent Models of Attention-Deficit/Hyperactivity Disorder
Sagvolden, T., Russell, V. A., Aase, H., Johansen, E. B., & Farshbaf, M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.002 · Cited by 448 · see citing works
Self-citationArnsten, A. F., & Dudley, A. G. (2005) · Behavioral and Brain Functions · doi:10.1186/1744-9081-1-2 · Cited by 363 · see citing works
Operant variability: Evidence, functions, and theory
Neuringer, A. (2002) · Psychonomic Bulletin & Review · doi:10.3758/bf03196324 · Cited by 272 · see citing works
The neuropharmacology of ADHD drugs in vivo: Insights on efficacy and safety
Heal, D. J., Cheetham, S. C., & Smith, S. L. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.08.020 · Cited by 198 · see citing works
The Effects of Methylphenidate on Goal-directed Behavior in a Rat Model of ADHD
Natsheh, J. Y., & Shiflett, M. W. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00326 · Cited by 21 · see citing works
- Authors
- Wultz, B., Sagvolden, T., Moser, E. I., & Moser, M.-B.
- Affiliations
- University of Oslo (NO)
- Venue
- Behavioral and Neural Biology
- Publisher
- Elsevier BV
- Published
- 1990-01
- Volume
- 53
- Issue
- 1
- Pages
- 88-102
- ISSN
- 0163-1047 (ISSN-L)
- OpenAlex
- W2046658074
- Cited by
- 144
- References
- 1
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 7
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral and Neural Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- spontaneously hypertensive rats, attention deficit hyperactivity disorder, methylphenidate, psychostimulants, exploratory behavior, hyperactivity, paradoxical drug reaction, stereotypy, rearing behavior, locomotor activity, open field, animal models
- MeSH terms
- Animals, Arousal, Attention Deficit Disorder with Hyperactivity, Disease Models, Animal, Dose-Response Relationship, Drug, Exploratory Behavior, Habituation, Psychophysiologic, Male, Methylphenidate, Motor Activity, Rats, Inbred SHR, Rats, Inbred WKY, Social Environment, Species Specificity, Rats
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