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“Paradoxical” effects of psychomotor stimulant drugs in hyperactive children from the standpoint of behavioural pharmacology
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These findings can be interpreted in the light of a hypothesized inverted U-shaped function relating dopamine and noradrenaline activity to performance.
“These findings can be interpreted in the light of a hypothesized inverted U-shaped function relating dopamine and noradrenaline activity to performance (Robbins and Sahakian, 1979).”
From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Robbins and Sahakian, 1979
It is consistent with a growing literature documenting baseline performance-dependent effects of stimulants and related drugs, which have been explained by a hypothesized inverted U-shaped function, whereby optimal catecholamine levels determine optimal performance, and levels along the curve at either side of the optimum are associated with impaired performance.
“It is also consistent with a growing literature documenting baseline performance-dependent effects of stimulants and related drugs, which have been explained by a hypothesized inverted U-shaped function, whereby optimal catecholamine levels determine optimal performance, and levels along the curve at either side of the optimum are associated with impaired performance (Robbins and Sahakian, 1979; N”
From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Robbins and Sahakian, 1979
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“Catecholamines (Dopamine/Norepinephrine)—Historically, ADHD was often considered a hypodopaminergic disorder (Levy, 1991; Robbins and Sahakian, 1979), where a deficiency in synaptic dopamine levels leads to clinical symptoms.”
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“In such schemas, increasing activity within a drug system is associated with improving performance, up to an optimum level beyond which increasing activity is associated with decreasing performance (Robbins & Sahakian, 1979; Zahrt, Taylor, Mathew, & Arnsten, 1997).”
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“Increased interest may explain why stimulants improve performance of a boring task in normal healthy individuals as well as in ADHD individuals (Robbins and Sahakian, 1979; Sahakian and Robbins, 1977) and why unmedicated children with ADHD are able to perform properly when the task is salient to them (Groom et al, 201…”
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BackgroundDopaminergic Modulation of Visual Attention and Working Memory in the Rodent Prefrontal Cortex
Chudasama, Y., & Robbins, T. W. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300490 · Cited by 233
“These baseline-dependent effects are more akin to the concept of ‘rate-dependency’ which assumes an inverse relationship between the control rate of responding and the drug effect (Dews, 1977; Dews and Wenger, 1977; Robbins and Sahakian, 1979).”
Self-citationTaylor, E. A., Schachar, R. J., Thorley, G., Wieselberg, H. M., Everitt, B. J., & Rutter, M. L. (1987) · Psychological Medicine · doi:10.1017/s0033291700013039 · Cited by 210
Methylphenidate and Children With Attention Deficit Disorder
Pelham, W. E. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790330028003 · Cited by 208
Jones, G. H., Marsden, C. A., & Robbins, T. W. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80050-6 · Cited by 171
Self-citationCoghill, D. R., Rhodes, S. M., & Matthews, K. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.030 · Cited by 170
Douglas, V. I., Barr, R. G., O'Neill, M. E., & Britton, B. G. (1986) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1986.tb02330.x · Cited by 161
Weiss, F., Paulus, M. P., Lorang, M. T., & Koob, G. F. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04372.1992 · Cited by 146
“For example, locomotor activation by stimulant drugs shows rate dependency in rodents, pigeons, and humans as does operant responding (Robbins and Sahakian, 1979).”
BackgroundAnimal Models Relevant to Schizophrenia and Autism: Validity and Limitations
Tordjman, S., Drapier, D., Bonnot, O., Graignic-Philippe, R., Fortes, S., Cohen, D., Millet, B., Laurent‐Levinson, C., & Roubertoux, P. L. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9120-5 · Cited by 147
“Later, Robbins and Sahakian (1979) kept only three criteria:”
BackgroundWultz, B., Sagvolden, T., Moser, E. I., & Moser, M.-B. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)90848-z · Cited by 144
DOSAGE EFFECTS AND INDIVIDUAL RESPONSIVITY TO METHYLPHENIDATE IN ATTENTION DEFICIT DISORDER
Douglas, V. I., Barr, R. G., Amin, K., O'Neill, M. E., & Britton, B. G. (1988) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1988.tb00737.x · Cited by 140
Fernando, A. B. P., Economidou, D., Theobald, D. E., Zou, M.-F., Newman, A. H., Spoelder, M., Caprioli, D., Moreno, M., Hipόlito, L., Aspinall, A. T., et al. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2408-z · Cited by 135
“Thus, the effects of methylphenidate on impulse control are evidently dependent on baseline levels of impulsivity, consistent with the rate-dependent effects of this compound in children (Robbins and Sahakian 1979).”
ResultSelf-citationStereotypy in monkeys and humans
Ridley, R. M., & Baker, H. F. (1982) · Psychological Medicine · doi:10.1017/s0033291700043294 · Cited by 134
Clinical Effects of Methylphenidate and Thioridazine in Intellectually Subaverage Children
Aman, M. G., MARKS, R. E., Turbott, S. H., Wilsher, C. P., & Merry, S. (1991) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199103000-00013 · Cited by 133
Solanto, M. V. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.95.3.387 · Cited by 121
WINSTANLEY, C. A. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.024 · Cited by 119
del Campo, N., Fryer, T. D., Hong, Y. T., Smith, R., Brichard, L., Acosta-Cabronero, J., Chamberlain, S. R., Tait, R., Izquierdo, D., Regenthal, R., et al. (2013) · Brain · doi:10.1093/brain/awt263 · Cited by 113
“…catecholamine levels determine optimal performance, and levels along the curve at either side of the optimum are associated with impaired per- formance (Robbins and Sahakian, 1979; Naylor et al., 1985; Williams and Goldman-Rakic, 1995; Kimberg et al., 1997; Arnsten and Goldman-Rakic, 1998;…”
BackgroundSelf-citationEffects of modafinil and methylphenidate on visual attention capacity: a TVA-based study
Finke, K., Dodds, C. M., Bublak, P., Regenthal, R., Baumann, F., Manly, T., & Müller, U. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1823-x · Cited by 119
“capacity, and the subsequent response to a drug (see, e.g., Farah et al. 2009; Kimberg et al. 1997; Robbins and Sahakian 1979, for a similar discussion).”
BackgroundRhodes, J. S., & Garland, T. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1399-9 · Cited by 116
“, cocaine, Ritalin, amphetamine) depend on baseline level of response, with low-baseline responders being stimulated and high-baseline responders being depressed (inverse rate-dependent effect) (Sanger and Blackman 1976; Robbins and Sahakian 1979; Solanto 1998; Rhodes et al. 2001).”
Amphetamine psychosis and schizophrenia: A dual model
Kokkinidis, L., & Anisman, H. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90015-4 · Cited by 114
Rhodes, S. M., Coghill, D. R., & Matthews, K. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01633.x · Cited by 112
“Specifically, there was no evidence for MPH reducing cognitive flexibility (see ID/ED results) as has previously been suggested (Robbins & Sahakian, 1979; Dyme, Sahakian, Golinko, & Rabe, 1982).”
BackgroundRapport, M. D., Stoner, G. D., DuPaul, G. J., Birmingham, B. K., & Tucker, S. B. (1985) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf00910644 · Cited by 109
Aman, M. G., KERN, R. A., McGhee, D. E., & Arnold, L. E. (1993) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199307000-00022 · Cited by 107
Rhodes, J., Hosack, G. R., Girard, I., Kelley, A., Mitchell, G. S., & Garland, T. (2001) · Psychopharmacology · doi:10.1007/s002130100857 · Cited by 105
“An inverse relationship between control rate and drug effect is generally found after treatment with DAT inhibitors (Sanger and Blackman 1976; Robbins and Sahakian 1979 ).”
BackgroundInfluentialDo High Doses of Stimulants Impair Flexible Thinking in Attention-Deficit Hyperactivity Disorder?
DOUGLAS, V. I., BARR, R. G., DESILETS, J., & SHERMAN, E. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199507000-00011 · Cited by 103
Aman, M. G., & Langworthy, K. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005559725475 · Cited by 104
Attenuation of hyperactivity in the spontaneously hypertensive rat by amphetamine
Myers, M. M., Musty, R. E., & Hendley, E. D. (1982) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(82)91397-8 · Cited by 100
d’Angelo, C., Savulich, G., & Sahakian, B. J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13813 · Cited by 98
“Stimulant drugs such as methylphenidate are known to have an inverted U-shaped function, where low baseline performance is enhanced but optimal, high-level performance may not change or may even be reduced (Sahakian and Robbins, 1977; Robbins and Sahakian, 1979).”
BackgroundSelf-citationEffects of Stimulant Drugs on Academic Performance in Hyperactive and Learning Disabled Children
Gadow, K. D. (1983) · Journal of Learning Disabilities · doi:10.1177/002221948301600509 · Cited by 94
“If, as has been hypothesized (Robbins & Sahakian 1979), stimulant drugs may produce cognitive perseveration at higher therapeutic doses, then those aspects of academic learning that require greater cognitive flexibility could be impaired or, at the very least, not respond to such dosages.”
BackgroundAttention deficit disorder with hyperactivity (ADDH): The contribution of catecholaminergic activity
Oades, R. D. (1987) · Progress in Neurobiology · doi:10.1016/0301-0082(87)90019-0 · Cited by 92
Methylphenidate Disrupts Social Play Behavior in Adolescent Rats
Vanderschuren, L. J. M. J., Trezza, V., Griffioen-Roose, S., Schiepers, O. J. G., Van Leeuwen, N., De Vries, T. J., & Schoffelmeer, A. N. M. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.10 · Cited by 105
Aman, M. G. (1982) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01538326 · Cited by 84
Taylor, E. (1986) · The British Journal of Psychiatry · doi:10.1192/bjp.149.5.562 · Cited by 82
The actions of opiates in the rat substantia nigra: An electrophysiological analysis
Hommer, D. W., & Pert, A. (1983) · Peptides · doi:10.1016/0196-9781(83)90004-9 · Cited by 74
Koirala, S., Grimsrud, G. J., Mooney, M. A., Larsen, B., Feczko, E., Elison, J. T., Nelson, S. M., Nigg, J. T., Tervo‐Clemmens, B., & Fair, D. A. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00869-z · Cited by 78
“Stimulants such as methylphenidate, as noted above, have led to the focus on catecholamine neurotransmission in ADHD pathophysiology 144,153 .”
Does Methylphenidate Constrict Cognitive Functioning?
Solanto, M. V., & Wender, E. H. (1989) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198911000-00014 · Cited by 70
Miller, E. M., Pomerleau, F., Huettl, P. F., Gerhardt, G. A., & Glaser, P. E. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3479-4 · Cited by 73
Attention-deficit hyperactivity disorder (ADHD) stimulant medications as cognitive enhancers
Advokat, C. D., & Scheithauer, M. C. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00082 · Cited by 78
“Results concerning risky behavior might be reinterpreted as evidence of stimulant-induced “inflexibility,” or “cognitive stereotopy,” which have been recognized for a long time (Robbins and Sahakian, 1979).”
BackgroundCaprioli, D., Jupp, B., Hong, Y. T., Sawiak, S. J., Ferrari, V., Wharton, L., Williamson, D. J., McNabb, C. B., Berry, D. W., Aigbirhio, F. I., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3890-14.2015 · Cited by 59
Self-citationCaprioli, D., Hong, Y. T., Sawiak, S. J., Ferrari, V., Williamson, D. J., Jupp, B., Adrian Carpenter, T., Aigbirhio, F. I., Everitt, B. J., Robbins, T. W., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.44 · Cited by 58
“Secondly, withdrawal from stimulant drugs (less than 3 weeks) is associated with behavioral sensitization to direct-acting D 2 receptor agonists (De Vries et al, 2002; Edwards et al, 2007; Robinson and Berridge, 2008; Ujike et al, 1990).”
Self-citationNeuropharmacology of Methylphenidate and a Neural Substrate for Childhood Hyperactivity
Gualtieri, C. T., & Hicks, R. E. (1985) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30661-0 · Cited by 58
Ruskin, D. N., Bergstrom, D. A., Shenker, A., Freeman, L. E., Baek, D., & Walters, J. R. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00987-2 · Cited by 57
The ethics of elective psychopharmacology
Mohamed, A. D., & Sahakian, B. J. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571100037x · Cited by 56
“Moreover, PCEs have been shown to improve cognition in healthy volunteers with no psychiatric disorders.”
BackgroundInfluentialSelf-citationChild Psychiatric Disorders in ICD‐10
Rutter, M. L. (1989) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1989.tb00264.x · Cited by 56
Costall, B., Domeney, A. M., & Naylor, R. J. (1984) · Psychopharmacology · doi:10.1007/bf00427768 · Cited by 51
Effects of Drugs on Schedule-Controlled Behavior
Sanger, D. J. (1987) · Humana Press eBooks · doi:10.1007/978-1-59259-461-0_5 · Cited by 50
Robbins, T. W. (2002) · Nature Medicine · doi:10.1038/nm0102-24 · Cited by 49
Self-citationTeicher, M. H., Polcari, A. M., Anderson, C. M., Andersen, S. L., Lowen, S. B., & Navalta, C. P. (2003) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/104454603321666180 · Cited by 48
“For children with ADHD, this means that the more hyperactive, dis-tractible, or impulsive the child is, the more effectively stimulants will act to enhance attention and reduce activity (Green and War-shauer 1981; Robbins and Sahakian 1979).”
d-Amphetamine remediates attentional performance in rats with dorsal prefrontal lesions
Chudasama, Y., Nathwani, F., & Robbins, T. W. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.08.011 · Cited by 48
Self-citationAnatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder
Ahn, M. S., Breeze, J. L., Makris, N., Kennedy, D. N., Hodge, S. M., Herbert, M. R., Seidman, L. J., Biederman, J., Caviness, V. S., & Frazier, J. A. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.04.015 · Cited by 48
“Rat models for bipolar disorder are based on medications known to induce mania, including cocaine and amphetamine (Brauer and de Wit, 1996; Robbins and Sahakian, 1979).”
BackgroundMethylphenidate in severely retarded residents and the clinical significance of stereotypic behavior
Aman, M. G., & Singh, N. N. (1982) · Applied Research in Mental Retardation · doi:10.1016/s0270-3092(82)80002-7 · Cited by 47
Bupropion attenuates methamphetamine self-administration in adult male rats
Reichel, C. M., Murray, J. E., Grant, K. M., & Bevins, R. A. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.09.006 · Cited by 46
“The ability of a locomotor stimulating drug, in our case bupropion, to reduce responding for a reinforcer raises concerns about the competitive nature of the concurrent behaviors (Robbins and Sahakian, 1979).”
BackgroundSOLANTO, M. V. (1986) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)60604-x · Cited by 43
Biphasic changes in mouse motor activity during exposure to toluene*1
Wood, R. W. (1990) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(90)90226-a · Cited by 45
Animal models to guide clinical drug development in ADHD: lost in translation?
Wickens, J. R., Hyland, B. I., & Tripp, G. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01412.x · Cited by 45
“Another possibility is that, as suggested by Sahakian and Robbins (1977) and Robbins and Sahakian (1979), stimulants increase stereotypic behaviour, thereby improving performance on tasks that require sustained attention.”
BackgroundThe effects of methylphenidate on learning in children with ADDH: The stimulus equivalence paradigm.
Vyse, S., & Rapport, M. D. (1989) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.57.3.425 · Cited by 44
Methylphenidate and cognitive perseveration in hyperactive children
Tannock, R., & Schachar, R. (1992) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1992.tb00940.x · Cited by 59
Psychostimulants in the treatment of children diagnosed with ADHD: Risks and mechanism of action
Breggin, P. R. (1999) · International Journal of Risk & Safety in Medicine · doi:10.3233/jrs-1999-177 · Cited by 38
“Robbins and Sahakian (1979) suggested that stimulant effects on children may result from the two basic behavior effects seen in animals: the reduction in “social interaction” and the”
LeBlanc, J. C., Binder, C. E., Armenteros, J. L., Aman, M. G., Wang, J. S., Hew, H., & Kusumakar, V. (2005) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000166403.03732.72 · Cited by 37
“stration of ‘rate dependency’, a statistical phenomenon in which subjects who are more extreme before pharmacological intervention show a larger treatment response (Robbins and Sahakian, 1979).”
BackgroundDolder, P. C., Strajhar, P., Vizeli, P., Odermatt, A., & Liechti, M. E. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4849-0 · Cited by 34
Attentional Processing in C57BL/6J Mice Exposed to Developmental Vitamin D Deficiency
Harms, L. R., Turner, K. M., Eyles, D. W., Young, J. W., McGrath, J. J., & Burne, T. H. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035896 · Cited by 35
“The 5-Choice Serial Reaction Task (5C-SRT) was developed as a test of attention in rats [23].”
MethodAnimal Models of Autism: An Epigenetic and Environmental Viewpoint
Iwata, K., Matsuzaki, H., Takei, N., Manabe, T., & Mori, N. (2010) · Journal of Central Nervous System Disease · doi:10.4137/jcnsd.s6188 · Cited by 35
Effects of d-amphetamine on aggressive responding of normal male subjects
Cherek, D. R., Steinberg, J. L., Kelly, T. H., & Robinson, D. (1987) · Psychiatry Research · doi:10.1016/0165-1781(87)90030-8 · Cited by 32
Agay, N., Yechiam, E., Carmel, Z., & Levkovitz, Y. (2014) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000076 · Cited by 32
Petrovsky, N., Ettinger, U., Quednow, B. B., Walter, H., Schnell, K., Kessler, H., Mößner, R., Maier, W., & Wagner, M. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2540-9 · Cited by 31
“The influence of baseline performance on subsequent response to a drug challenge has been previously discussed by a number of other authors (Kimberg et al. 1997; Mattay et al. 2000; Mehta 2002; Mehta et al. 2000; Robbins and Sahakian 1979) demonstrating that despite the absence of an overall effect of a drug, the drug…”
BackgroundOrder in the absence of an effect: Identifying rate-dependent relationships
Snider, S. E., Quisenberry, A. J., & Bickel, W. K. (2016) · Behavioural Processes · doi:10.1016/j.beproc.2016.03.012 · Cited by 30
“Moreover, rate dependence was also demonstrated in healthy adults and children along with hyperactive children following amphetamine administration (Robbins and Sahakian 1979).”
BackgroundGrünblatt, E., Homolak, J., Perhoč, A. B., Virag, D., Knezović, A., Barilar, J. O., Riederer, P., Walitza, S., Tackenberg, C., & Šalković‐Petrišić, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1104985 · Cited by 26
“However, the paradoxical calming effects of psychostimulants in ADHD have still not been fully understood (Robbins and Sahakian, 1979; Harris et al., 2022).”
BackgroundPharmacotherapy for Behavior Disorders
Gadow, K. D. (1983) · Clinical Pediatrics · doi:10.1177/000992288302200106 · Cited by 27
Ciprandi, G., AMICI, M. D., Quaglini, S., Labò, E., Castellazzi, A. M., Giudice, M. M. M. D., Marseglia, A., Bianchi, L., Moratti, R., & Marseglia, G. L. (2012) · PubMed · Cited by 26
Neural and Behavioral Endophenotypes in ADHD
del Campo, N., Müller, U., & Sahakian, B. J. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_200 · Cited by 26
Self-citationHeyman, G. M. (1992) · Psychopharmacology · doi:10.1007/bf02245492 · Cited by 25
Does haloperidol block methylphenidate?
Lévy, F., & Hobbes, G. (1996) · Psychopharmacology · doi:10.1007/bf02246413 · Cited by 25
“Robbins and Sahakian (1979, 1983) have argued from animal studies and human data that the effect of amphetamine on hyperactive children is not "paradoxical".”
BackgroundMouse feeding behavior: ethology, regulatory mechanisms and utility for mutant phenotyping
Heinrichs, S. C. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00287-x · Cited by 24
The utility of behavioral economics in expanding the free-feed model of obesity
Rasmussen, E. B., Robertson, S. H., & Rodriguez, L. R. (2016) · Behavioural Processes · doi:10.1016/j.beproc.2016.02.014 · Cited by 24
“The most fundamental properties of animals models have been a topic of discussion for decades (e.g., see McKinney, 1977; Robbins & Sahakian, 1979; Robinson & Becker, 1986; Torjman et al., 2007).”
BackgroundAn involvement of dopamine in higher order choice mechanisms in the monkey
Ridley, R. M., Haystead, T., & Baker, H. F. (1981) · Psychopharmacology · doi:10.1007/bf00431652 · Cited by 22
School Involvement in Pharmacotherapy for Behavior Disorders
Gadow, K. D. (1982) · The Journal of Special Education · doi:10.1177/002246698201600403 · Cited by 22
Narcolepsy and Its Treatment With Stimulants
Mitler, M. M., Aldrich, M. S., Koob, G. F., & Zarcone, V. P. (1994) · SLEEP · doi:10.1093/sleep/17.4.352 · Cited by 21
Methylphenidate in Hyperactive and Enuretic Children
WERRY, J. S., & Aman, M. G. (1984) · Springer eBooks · doi:10.1007/978-94-011-6701-7_9 · Cited by 20
Rate-dependency and hyperactivity: Methylphenidate effects on operant responding
Rapport, M. D., DuPaul, G. J., & Smith, N. F. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90133-9 · Cited by 19
Methylphenidate enhances implicit learning in healthy adults
Klinge, C., Shuttleworth, C., Muglia, P., Nobre, A. C., Harmer, C. J., & Murphy, S. E. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117731472 · Cited by 20
“A low dose was also chosen in light of the hypothesised inverted U-shaped relationship between cognitive performance and DA activity (Cools and D’Esposito, 2011; Goldman-Rakic et al., 2000; Robbins and Arnsten, 2009; Robbins and Sahakian, 1979).”
Background
Metadata
- Authors
- Robbins, T. W., & Sahakian, B. J.
- Affiliations
- University of Cambridge (GB)
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Robbins, T.W.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 1979-12
- Volume
- 18
- Issue
- 12
- Pages
- 931-950
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2007634374
- Cited by
- 170
- References
- 93
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 6 · 2012: 8
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- hyperactivity, hyperkinetic disorder, psychostimulants, methylphenidate, amphetamine, rate dependence, attention, cognitive flexibility, stereotypy
- MeSH terms
- Central Nervous System Stimulants, Attention, Behavior, Child, Humans, Hyperkinesis, Social Behavior, Stereotyped Behavior
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