The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Metabolism and mechanism of action of 5-fluorouracil
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fluorinated pyrimidines, a new class of tumour-inhibitory compounds
HEIDELBERGER, C., CHAUDHURI, N. K., DANNEBERG, P., MOOREN, D., GRIESBACH, L., DUSCHINSKY, R., SCHNITZER, R. J., PLEVEN, E., & SCHEINER, J. (1957) · Nature · doi:10.1038/179663a0 · Cited by 1,603
Splicing of Messenger RNA Precursors
Sharp, P. A. (1987) · Science · doi:10.1126/science.3544217 · Cited by 901
Lindahl, T. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.000425 · Cited by 895
Thymidylate synthetase - a target enzyme in cancer chemotherapy
Danenberg, P. V. (1977) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(77)90001-4 · Cited by 502
Harris, B., Song, R., Soong, S.-J., & Diasio, R. B. (1990) · PubMed · Cited by 441
On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs
Santi, D. V., Garrett, C. E., & Barr, P. J. (1983) · Cell · doi:10.1016/0092-8674(83)90327-6 · Cited by 401
Murray‐Rust, P., Stallings, W. C., Monti, C. T., Preston, R. K., & GLUSKER, J. P. (1983) · Journal of the American Chemical Society · doi:10.1021/ja00348a041 · Cited by 310
Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.
Evans, R. M., Jd, L., & Hakala, M. T. (1981) · PubMed · Cited by 284
Nakada, D., & Magasanik, B. (1964) · Journal of Molecular Biology · doi:10.1016/s0022-2836(64)80153-4 · Cited by 278
Yoshioka, A., Tanaka, S., Hiraoka, O., Koyama, Y., Hirota, Y., Ayusawa, D., Seno, T., Garrett, C., & Wataya, Y. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47554-0 · Cited by 252
Cited by
Disruption of p53 in human cancer cells alters the responses to therapeutic agents.
Bunz, F., Hwang, P. M., Torrance, C., Waldman, T., Zhang, Y., Dillehay, L., Williams, J., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6863 · Cited by 1,044
Domingo, E., Sheldon, J., & Perales, C. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05023-11 · Cited by 1,009
5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future
Vodenkova, S., Buchler, T., Cervena, K., Veskrnova, V., Vodicka, P., & Vymetalkova, V. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107447 · Cited by 956
Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer
Parker, W. B. (2009) · Chemical Reviews · doi:10.1021/cr900028p · Cited by 622
Self-citationClinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): A review
Malet-Martino, M., & Martino, R. (2002) · The Oncologist · doi:10.1634/theoncologist.7-4-288 · Cited by 382
Metadata
- Authors
- Parker, W. B., & Cheng, Y. C.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 1990-01
- Volume
- 48
- Issue
- 3
- Pages
- 381-395
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2015445088
- Cited by
- 451
- References
- 55
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Metabolism and mechanism of action of 5-fluorouracil. https://app.cochat.ai/papers/10.1016/0163-7258(90)90056-8
- The paper
- Parker, W. B., & Cheng, Y. C. (1990). Metabolism and mechanism of action of 5-fluorouracil. Pharmacology & Therapeutics. https://doi.org/10.1016/0163-7258(90)90056-8
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
