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Cited by 49Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesBipolar Disorder and Treatment

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The pattern of physical symptom changes in major depressive disorder following treatment with amitriptyline or imipramine

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Casper, Regina C., Katz, Martin M., Bowden, Charles L., Davis, John M., Koslow, Stephen H., Hanin, Israel·1994·Journal of Affective Disorders
DOI 10.1016/0165-0327(94)90024-8
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Abstract

The study describes a sequential analysis of depression-related physical symptoms and their relationship to imipramine and amitriptyline plasma levels over 4 weeks of treatment in 79 unipolar and bipolar patients hospitalized for major depressive disorder. Insomnia diminished in all patients after 2 weeks of drug administration. After 4 weeks, the sleep of patients whose depressive disorder has significantly improved was nearly normal, whereas patients who remained depressed showed continued sleep impairment. Reductions in loss of appetite, weight and sexual interest paralleled mood improvement. Tricyclic plasma levels significantly correlated with improved sleep. The findings suggest a close link between depressed mood and physical symptoms during recovery from major depressive disorder.

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  1. Braithwaite, 1972, Plasma concentration of amitriptyline and clinical response, Lancet, 17, 1297, 10.1016/S0140-6736(72)91031-8 · DOI
  2. Carl, 1985, Cerebrospinal fluid level of amitriptyline, nortriptyline, imipramine and desmethylimipramine: relationship to plasma levels and treatment outcome, J. Affect. Disord., 9, 69, 10.1016/0165-0327(85)90012-6 · DOI
  3. Casper, 1985, Somatic symptoms in primary affective disorder: presence and relationship to the classification of depression, Arch. Gen. Psychiatry, 42, 1098, 10.1001/archpsyc.1985.01790340082012 · DOI · Paper page
  4. Coppen, 1979, Zimelidine: a therapeutic and pharmacokinetic study in depression, Psychopharmacology, 63, 199, 10.1007/BF00433549 · DOI
  5. Coryell, 1982, Early improvement as a predictor of response to amitriptyline and nortriptyline: a comparison of two patient samples, Psychol. Med., 12, 135, 10.1017/S0033291700043385 · DOI
  6. Davidson, 1986, Diagnostic significance of vegetative symptoms in depression, Br. J. Psychiatry, 148, 442, 10.1192/bjp.148.4.442 · DOI · Paper page
  7. Derogatis, 1974, The Hopkins Symptom Checklist (HSCL): A measure of primary symptom dimensions, Vol. 7, 79
  8. Di Mascio, 1979, Defferential symptom reduction by drugs and psychotherapy in acute depression, Arch. Gen. Psychiatry, 36, 1450, 10.1001/archpsyc.1979.01780130068008 · DOI
  9. Endicott, 1976, The Global assessment scale: a procedure for measuring overall severity of psychiatric disturbances, Arch. Gen. Psychiatry, 33, 766, 10.1001/archpsyc.1976.01770060086012 · DOI · Paper page
  10. Endicott, 1978, A diagnostic interview: the schedule for affective disorders and schizophrenia, Arch. Gen. Psychiatry, 35, 837, 10.1001/archpsyc.1978.01770310043002 · DOI
  11. Fava, 1991, Prodromal symptoms in affective disorders, Am. J. Psychiatry, 148, 823, 10.1176/ajp.148.7.823 · DOI
  12. Gaszner, 1980, Comparison of the peripheral anticholinergic activities of desipramine and amitriptyline in healthy volunteers, Br. J. Clin. Pharmacol., 9, 123, 10.1111/j.1365-2125.1980.tb04825.x · DOI
  13. Haider, 1968, A comparative investigation of desipramine and nortriptyline in the treatment of depression, Br. J. Psychiatry, 114, 1293, 10.1192/bjp.114.515.1293 · DOI
  14. Hamilton, 1960, A rating scale for depression, J. Neurol. Neurosurg. Psychiatry, 23, 56, 10.1136/jnnp.23.1.56 · DOI · Paper page
  15. Hamilton, 1967, Development of a rating scale for primary depressive illness, Br. J. Soc. Clin. Psychol., 6, 278, 10.1111/j.2044-8260.1967.tb00530.x · DOI
  16. Haskell, 1975, Rapidity of symptom reduction in depressions treated with amitriptyline, J. Nerv. Ment. Dis., 160, 24, 10.1097/00005053-197501000-00005 · DOI
  17. Hibbert, 1984, Covariation of depressive symptoms over time, Psychol. Med., 14, 451, 10.1017/S0033291700003718 · DOI
  18. Hollister, 1964, Controlled comparison of amitriptyline, imipramine and placebo in hospitalized depressed patients, J. Nerv. Ment. Dis., 139, 370, 10.1097/00005053-196410000-00009 · DOI
  19. Hopkinson, 1965, The prodromal phase of the depressive psychosis, Psychiatr. Neurol., 149, 1, 10.1159/000128798 · DOI
  20. Hordern, 1963, Amitriptyline in depressive states: Phenomenology and prognostic considerations, Br. J. Psychiatry, 109, 815, 10.1192/bjp.109.463.815 · DOI
  21. Isaksson, 1968, A comparison between imipramine and protriptyline in the treatment of depressed outpatients, Acta Psychiatr. Scand., 44, 205, 10.1111/j.1600-0447.1968.tb07508.x · DOI
  22. Joyce, 1989, Predictors of drug response in depression, Arch. Gen. Psychiatry, 46, 8904, 10.1001/archpsyc.1989.01810010091014 · DOI
  23. Katz, 1974, Video methodology for research in psychopathology and psychopharmacology, Arch. Gen. Psychiatry, 31, 204, 10.1001/archpsyc.1974.01760140056009 · DOI
  24. Katz, 1979, NIMH Clinical Research Collaborative Program on the Psychobiology of Depression, Arch. Gen. Psychiatry, 36, 765, 10.1001/archpsyc.1979.01780070043004 · DOI
  25. Katz, 1984, Multivantaged approach to the measurement of behavioral and affect states for clinical psychobiological research, Psychol. Rep., 55, 619, 10.2466/pr0.1984.55.2.619 · DOI
  26. Katz, 1987, The timing, specificity and clinical predicting of tricyclic drug effects in depression, Psychol. Med., 17, 297, 10.1017/S0033291700024831 · DOI
  27. Katz, 1991, Identifying the specific clinical actions of amitriptyline: interrelationships of behavior, affect and plasma levels in depression, Psychol. Med., 21, 599, 10.1017/S0033291700022236 · DOI
  28. Kessell, 1970, A controlled study of nortriptyline and imipramine, Am. J. Psychiatry, 126, 938, 10.1176/ajp.126.7.938 · DOI
  29. Kocsis, 1986, Imipramine and amitriptyline plasma concentration and clinical response in major depression, Br. J. Psychiatry, 148, 52, 10.1192/bjp.148.1.52 · DOI
  30. Kupfer, 1972, Interval between onset of sleep and rapid-eye-movement sleep as an indicator of depression, Lancet, ii, 684, 10.1016/S0140-6736(72)92090-9 · DOI
  31. Kupfer, 1980, Depression, EEG sleep and clinical response, Compreh. Psychiatry, 21, 212, 10.1016/0010-440X(80)90005-X · DOI
  32. Maas, 1980, Biological component of the NIMH Clinical Research Branch Collaborative Program in the Psychobiology of depression: I. Background theoretical considerations, Psychol. Med., 10, 759, 10.1017/S0033291700055057 · DOI
  33. Morris, 1974, The efficacy of antidepressant drugs: a review of research (1958–1972), Arch. Gen. Psychiatry, 30, 667, 10.1001/archpsyc.1974.01760110083010 · DOI
  34. Nakra, 1977, Amitriptyline and weight gain: a biological and endocrinological study, Curr. Med. Res. Opin., 4, 602, 10.1185/03007997709115277 · DOI
  35. Nelson, 1984, Drug-responsive symptoms in melancholia, Arch. Gen. Psychiatry, 41, 663, 10.1001/archpsyc.1984.01790180033004 · DOI
  36. Nelson, 1981, The symptoms of major depressive illness, Am. J. Psychiatry, 138, 1, 10.1176/ajp.138.1.1 · DOI
  37. Paykel, 1973, Amitriptyline, weight gain and carbohydrate craving — a side effect, Br. J. Psychiatry, 123, 501, 10.1192/bjp.123.5.501 · DOI
  38. Preskorn, 1984, The implication of concentration/response studies of tricyclic antidepressants for psychiatric research and practice, Psychiatr. Dev., 3, 201
  39. Quitkin, 1984, Identification of true drug response to anti-depressants: use of pattern analysis, Arch. Gen. Psychiatry, 41, 782, 10.1001/archpsyc.1984.01790190056007 · DOI
  40. Raskin, 1970, Differential response to chlorpromazine, imipramine and placebo, Arch. Gen. Psychiatry, 23, 164, 10.1001/archpsyc.1970.01750020068009 · DOI
  41. Rathburn, 1963, Amitriptyline and nortriptyline as antagonists of central and peripheral cholinergic activation, Psychopharmacologia, 4, 114, 10.1007/BF00413329 · DOI
  42. Secunda, 1980, Biological component of the NIMH Clinical Research Branch Collaborative Program on the Psychobiology of Depression: I. Methodology and data analysis, Psychol. Med., 10, 777, 10.1017/S0033291700055069 · DOI
  43. Spitzer, 1978, Research diagnostic criteria: rationale and reliability, Arch. Gen. Psychiatry, 35, 382, 10.1001/archpsyc.1978.01770300115013 · DOI
  44. Stewart, 1968, A comparative trial of desipramine and nortriptyline in depression, Br. J. Psychiatry, 114, 469, 10.1192/bjp.114.509.469 · DOI
  45. Van Praag, 1965, The vital syndrome interview, Psychiatr. Neurol. Neurochir., 68, 329
  46. Winokur, 1979, Unipolar depression: is it divisible into autonomous subtypes?, Arch. Gen. Psychiatry, 36, 47, 10.1001/archpsyc.1979.01780010053005 · DOI
  47. Ziegler, 1977, A comparison study of amitriptyline and nortriptyline with plasma levels, Arch. Gen. Psychiatry, 34, 607, 10.1001/archpsyc.1977.01770170117012 · DOI

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Metadata

Authors
Casper, R. C., Katz, M. M., Bowden, C. L., Davis, J. M., Koslow, S. H., & Hanin, I.
Affiliations
  • Stanford Medicine (US)
  • Albert Einstein College of Medicine (US)
  • The University of Texas at San Antonio Health Science Center (US)
  • National Institutes of Health (US)
  • Loyola University Chicago (US)
Corresponding author
Casper, Regina C.
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
1994-07
Volume
31
Issue
3
Pages
151-164
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/0165-0327(94)90024-8
OpenAlex
W2043913146
Cited by
49
References
1
Citations by year
2024: 1 · 2018: 1 · 2016: 3 · 2015: 2 · 2013: 2 · 2012: 2
FWCI
1.08
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Affective Disorders (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (U01MH026977, U01 MH26976, U01MH026979)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords
major depressive disorder, amitriptyline, imipramine, tricyclic antidepressants, plasma drug concentration, somatic symptoms, insomnia, sleep disorders, appetite loss, weight loss, sexual interest, bipolar depression, antidepressant response
MeSH terms
Adult, Affect, Amitriptyline, Appetite, Arousal, Bipolar Disorder, Body Weight, Depressive Disorder, Female, Humans, Imipramine, Libido, Male, Middle Aged, Personality Inventory, Sleep Stages, Somatoform Disorders

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