The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Deposits of IgG and C3 in the spinal cord and motor cortex of ALS patients
Abstract
Deposits of IgG and complement were demonstrated by direct immunofluorescent techniques with sections of motor cortex and spinal cord from amyotrophic lateral sclerosis (ALS) patients. Six of 16 ALS patients showed deposits within the spinal cord while 5 of 13 showed similar deposits within the motor cortex. The specificity of this staining was shown by blocking experiments and the use of conjugated F(ab')2. Similar deposits were found in the CNS in disease states associated with possible immune or infectious etiologies and were not found in the CNS of normal controls.
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“These findings support earlier observations showing that the BBB and BSCB are damaged in a subset of ALS patients as demonstrated by accumulation of plasma-derived IgG in the spinal cord and motor cortex in 40% (154) to 90% (163) of studied cases, and accumulation of peripheral blood cells in 70% (164) to 100% (599) of studied cases.”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [154]
Citations
Cites
Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions
Prineas, J. W., & Raine, C. S. (1976) · Neurology · doi:10.1212/wnl.26.6_part_2.29 · Cited by 113
Binding of normal human IgG to myelin sheaths, glia and neurons.
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EVIDENCE FOR IMMUNE-COMPLEX FORMATION IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
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Oligodendrocyte staining by multiple sclerosis serum is nonspecific
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ACETYLCHOLINE-RECEPTOR ANTIBODIES IN CEREBROSPINAL FLUID OF PATIENTS WITH MYASTHENIA GRAVIS
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Amyotrophic Lateral Sclerosis: Recent Research Trends
Mulder, D. W. (1977) · JAMA · doi:10.1001/jama.1977.03270500094044 · Cited by 44
Bartfeld, H., Dham, C., Donnenfeld, H., Jashnani, L., Carp, R., Kascsak, R., Vilček, J., Rapport, M. M., & Wallenstein, S. R. (1982) · PubMed Central · Cited by 42
Self-citationPotential pathogenic mechanisms of injury in amyotrophic lateral sclerosis.
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Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
The blood–brain barrier in health and disease
Daneman, R. (2012) · Annals of Neurology · doi:10.1002/ana.23648 · Cited by 794
Brain metabolism in health, aging, and neurodegeneration
Camandola, S., & Mattson, M. P. (2017) · The EMBO Journal · doi:10.15252/embj.201695810 · Cited by 752
The blood–spinal cord barrier: Morphology and Clinical Implications
Bartanusz, V., Ježová, D., Alajajian, B., & Digicaylioglu, M. H. (2011) · Annals of Neurology · doi:10.1002/ana.22421 · Cited by 495
Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis
Winkler, E. A., Sengillo, J. D., Sullivan, J. S., Henkel, J. S., Appel, S. H., & Zlokovic, B. V. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1039-8 · Cited by 354
Metadata
- Authors
- Donnenfeld, H., Kascsak, R. J., & Bartfeld, H.
- Affiliations
- Saint Vincent's Catholic Medical Center (US)
- Corresponding author
- Donnenfeld, H.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 1984-02
- Volume
- 6
- Issue
- 1
- Pages
- 51-57
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2012006815
- Cited by
- 119
- References
- 8
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 15 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 8
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- amyotrophic lateral sclerosis, IgG deposits, complement C3, spinal cord, motor cortex, neuroinflammation, immune deposits, central nervous system, direct immunofluorescence
- MeSH terms
- Aged, Amyotrophic Lateral Sclerosis, Antibodies, Antigen-Antibody Complex, Binding, Competitive, Complement C3, Female, Fluorescent Antibody Technique, Humans, Immunoglobulin G, Male, Middle Aged, Motor Cortex, Spinal Cord
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