Cited by 119Amyotrophic Lateral Sclerosis ResearchPeripheral Neuropathies and DisordersMultiple Sclerosis Research Studies

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Deposits of IgG and C3 in the spinal cord and motor cortex of ALS patients

Donnenfeld, H., Kascsak, R.J., Bartfeld, H.·1984·Journal of Neuroimmunology

DOI 10.1016/0165-5728(84)90042-0

Open this paper in CoChat — free account

Abstract

Deposits of IgG and complement were demonstrated by direct immunofluorescent techniques with sections of motor cortex and spinal cord from amyotrophic lateral sclerosis (ALS) patients. Six of 16 ALS patients showed deposits within the spinal cord while 5 of 13 showed similar deposits within the motor cortex. The specificity of this staining was shown by blocking experiments and the use of conjugated F(ab')2. Similar deposits were found in the CNS in disease states associated with possible immune or infectious etiologies and were not found in the CNS of normal controls.

Integrity signals

Registry

Crossref · 10.1016/0165-5728(84)90042-0

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions
Prineas, J. W., & Raine, C. S. (1976) · Neurology · doi:10.1212/wnl.26.6_part_2.29 · Cited by 113
Binding of normal human IgG to myelin sheaths, glia and neurons.
Aarli, J. A., Aparicio, S. R., LUMSDEN, C. E., & Tönder, O. (1975) · PubMed Central · Cited by 108
EVIDENCE FOR IMMUNE-COMPLEX FORMATION IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
Oldstone, M. B. A., Perrin, L. H., Wilson, C. B., & Norris, F. H. (1976) · The Lancet · doi:10.1016/s0140-6736(76)92345-x · Cited by 65
Oligodendrocyte staining by multiple sclerosis serum is nonspecific
Traugott, U., Snyder, D. S., & Raine, C. S. (1979) · Annals of Neurology · doi:10.1002/ana.410060104 · Cited by 63
ACETYLCHOLINE-RECEPTOR ANTIBODIES IN CEREBROSPINAL FLUID OF PATIENTS WITH MYASTHENIA GRAVIS
Lefvert, A. K., & Pirskanen, R. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91506-9 · Cited by 57
Amyotrophic Lateral Sclerosis: Recent Research Trends
Mulder, D. W. (1977) · JAMA · doi:10.1001/jama.1977.03270500094044 · Cited by 44
Immunological profile of amyotrophic lateral sclerosis patients and their cell-mediated immune responses to viral and CNS antigens.
Bartfeld, H., Dham, C., Donnenfeld, H., Jashnani, L., Carp, R., Kascsak, R., Vilček, J., Rapport, M. M., & Wallenstein, S. R. (1982) · PubMed Central · Cited by 42
Self-citation
Potential pathogenic mechanisms of injury in amyotrophic lateral sclerosis.
Oldstone, M. B. A., Lh, P., & Rm, W. (1976) · PubMed · Cited by 3

Show all 8 references

Sorted by citations

Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
The blood–brain barrier in health and disease
Daneman, R. (2012) · Annals of Neurology · doi:10.1002/ana.23648 · Cited by 797
Brain metabolism in health, aging, and neurodegeneration
Camandola, S., & Mattson, M. P. (2017) · The EMBO Journal · doi:10.15252/embj.201695810 · Cited by 752
The blood–spinal cord barrier: Morphology and Clinical Implications
Bartanusz, V., Ježová, D., Alajajian, B., & Digicaylioglu, M. H. (2011) · Annals of Neurology · doi:10.1002/ana.22421 · Cited by 497
Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis
Winkler, E. A., Sengillo, J. D., Sullivan, J. S., Henkel, J. S., Appel, S. H., & Zlokovic, B. V. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1039-8 · Cited by 354
Inflammation in ALS/FTD pathogenesis
McCauley, M. E., & Baloh, R. H. (2019) · Acta Neuropathologica · doi:10.1007/s00401-018-1933-9 · Cited by 341
Barrier function in the peripheral and central nervous system—a review
Reinhold, A., & Rittner, H. L. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1920-8 · Cited by 285
Evidence of Compromised Blood-Spinal Cord Barrier in Early and Late Symptomatic SOD1 Mice Modeling ALS
Garbuzova-Davis, S. N., Saporta, S., Haller, E. M., Kolomey, I., Bennett, S. P., Potter, H., & Sanberg, P. R. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001205 · Cited by 253
Ultrastructure of blood–brain barrier and blood–spinal cord barrier in SOD1 mice modeling ALS
Garbuzova-Davis, S., Haller, E., Saporta, S., Kolomey, I., Nicosia, S. V., & Sanberg, P. R. (2007) · Brain Research · doi:10.1016/j.brainres.2007.04.044 · Cited by 239
The Role of Immune and Inflammatory Mechanisms in ALS
McCombe, P., & Henderson, R. D. (2011) · Current Molecular Medicine · doi:10.2174/156652411795243450 · Cited by 238
IgG Reactivity in the Spinal Cord and Motor Cortex in Amyotrophic Lateral Sclerosis
Engelhardt, J. I., & Appel, S. H. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530110068019 · Cited by 221
Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System
Carpanini, S. M., Torvell, M., & Morgan, B. P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00362 · Cited by 217
Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases
Brkic, M., Balusu, S., Libert, C., & Vandenbroucke, R. E. (2015) · Mediators of Inflammation · doi:10.1155/2015/620581 · Cited by 205
Inflammation and neurovascular changes in amyotrophic lateral sclerosis
Evans, M. C., Couch, Y., Sibson, N. R., & Turner, M. R. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.10.008 · Cited by 179
Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia
Lall, D., & Baloh, R. H. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90607 · Cited by 175
Impaired blood–brain and blood–spinal cord barriers in mutant SOD1-linked ALS rat
Nicaise, C., Mitrecic, D., Demetter, P., De Decker, R., Authelet, M., Boom, A., & Pochet, R. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.018 · Cited by 168
Motor Neuron Disease (Amyotrophic Lateral Sclerosis)
WILLIAMS, D. B., & Windebank, A. J. (1991) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)61175-6 · Cited by 154
Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD
Pineda, S. S., Lee, H., Fitzwalter, B. E., Mohammadi, S., Pregent, L., Gardashli, M., Mantero, J. C., Engelberg-Cook, E., DeJesus‐Hernandez, M., van Blitterswijk, M., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.031 · Cited by 159
Blood-CNS Barrier Impairment in ALS patients versus an animal model
Garbuzova-Davis, S. N., & Sanberg, P. R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00021 · Cited by 152
Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons
Lobsiger, C. S., Boillée, S., & Cleveland, D. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702230104 · Cited by 139
Amyotrophic lateral sclerosis: A neurovascular disease
Garbuzova-Davis, S. N., Rodrigues, M. C. O., Hernandez‐Ontiveros, D. G., Louis, M. K., Willing, A. E., Borlongan, C. V., & Sanberg, P. R. (2011) · Brain Research · doi:10.1016/j.brainres.2011.04.049 · Cited by 130
LRP 4 antibodies in serum and CSF from amyotrophic lateral sclerosis patients
Tzartos, J. S., Zisimopoulou, P., Rentzos, M., Karandreas, N., Zouvelou, V., Evangelakou, P., Tsonis, A., Thomaides, T., Lauria, G., Andreetta, F., et al. (2013) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.26 · Cited by 117
Serum and CSF immunological findings in ALS
Apostolski, S., Nikolić, J., Bugarski-Prokopljević, C., Miletić, V., Pavlović, S., & Filipović, S. (1991) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1991.tb04656.x · Cited by 114
New tricks for an ancient system: Physiological and pathological roles of complement in the CNS
Tenner, A. J., Stevens, B., & Woodruff, T. M. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.06.264 · Cited by 115
Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration
Wilkins, H. M., Weidling, I. W., Ji, Y., & Swerdlow, R. H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00508 · Cited by 102
Non‐neuronal Cells in ALS: Role of Glial, Immune cells and Blood‐CNS Barriers
Puentes, F., Malaspina, A., van Noort, J. M., & Amor, S. (2016) · Brain Pathology · doi:10.1111/bpa.12352 · Cited by 100
Amyotrophic Lateral Sclerosis
Mitsumoto, H. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520260077025 · Cited by 98
TNF and sTNFR1/2 plasma levels in ALS patients
Cereda, C., Baiocchi, C., Bongioanni, P., Cova, E., Guareschi, S., Metelli, M. R., Rossi, B., Sbalsi, I., Cuccia, M. C., & Ceroni, M. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.10.028 · Cited by 94
Elevation of the terminal complement activation products C5a and C5b-9 in ALS patient blood
Mantovani, S., Gordon, R., Macmaw, J. K., Pfluger, C. M., Henderson, R. D., Noakes, P. G., McCombe, P., & Woodruff, T. M. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.09.005 · Cited by 78
Complement in the Pathophysiology and Diagnosis of Human Diseases
Dalmasso, A. P. (1986) · CRC Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408368609110272 · Cited by 78
Basal lamina changes in neurodegenerative disorders
Nguyen, B., Bix, G., & Yao, Y. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00502-y · Cited by 75
TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model
Zamudio, F., Loon, A. R., Smeltzer, S., Benyamine, K., Shanmugam, N. K. N., Stewart, N. J., Lee, D. C., Nash, K. R., & Selenica, M. B. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01952-9 · Cited by 78
The Complement System in the Central Nervous System: From Neurodevelopment to Neurodegeneration
Chen, Y., Chu, J. M. T., Chang, R. C., & Wong, G. T. C. (2022) · Biomolecules · doi:10.3390/biom12020337 · Cited by 78
Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions
Brennan, F. H., Lee, J. D., Ruitenberg, M. J., & Woodruff, T. M. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.03.015 · Cited by 73
High levels of C3c in the cerebrospinal fluid from amyotrophic lateral sclerosis patients
Annunziata, P., & Volpi, N. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1985.tb01548.x · Cited by 70
Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis
Saul, J., Hutchins, E. D., Reiman, R. A., Saul, M., Ostrow, L. W., Harris, B. T., Keuren‐Jensen, K. R. V., Bowser, R. P., & Bakkar, N. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00968-9 · Cited by 68
Blood-CNS barrier dysfunction in amyotrophic lateral sclerosis: Proposed mechanisms and clinical implications
Steinruecke, M., Lonergan, R. M., Selvaraj, B. T., Chandran, S., Castro, B. D., & Stavrou, M. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231153281 · Cited by 64
Complement Has Brains—Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior?
Kunz, N., & Kemper, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.629986 · Cited by 63
Aberrant Complement System Activation in Neurological Disorders
Ziąbska, K., Ziemka‐Nałęcz, M., Pawelec, P., Sypecka, J., & Zalewska, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094675 · Cited by 54
Increased concentration of C4d complement protein in CSF in amyotrophic lateral sclerosis.
Tsuboi, Y., & Yamada, T. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.7.859 · Cited by 54
Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact
Marchi, F. D., Munitić, I., Amedei, A., Berry, J. D., Feldman, E. L., Aronica, E., Nardo, G., Weehaeghe, D. V., Niccolai, E., Prtenjača, N., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.027 · Cited by 52
Altered blood–brain barrier and blood–spinal cord barrier dynamics in amyotrophic lateral sclerosis: Impact on medication efficacy and safety
Pan, Y., & Nicolazzo, J. A. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15802 · Cited by 49
Anti-neural antibodies in serum and cerebrospinal fluid of amyotrophic lateral sclerosis (ALS) patients
Niebrój-Dobosz, I., Jamrozik, Z., Janik, P., Hausmanowa-Petrusewicz, I., & Kwieciński, H. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1999.tb00387.x · Cited by 52
Pharmacological targeting of the PDGF-CC signaling pathway for blood–brain barrier restoration in neurological disorders
Lewandowski, S. A., Fredriksson, L., Lawrence, D. A., & Eriksson, U. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.016 · Cited by 55
Alterations of the blood‐spinal cord barrier in sporadic amyotrophic lateral sclerosis
Sasaki, S. (2015) · Neuropathology · doi:10.1111/neup.12221 · Cited by 50
Revisiting the role of the innate immune complement system in ALS
Parker, S. E., Hanton, A. M., Stefanou, S. N., Noakes, P. G., Woodruff, T. M., & Lee, J. D. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.03.003 · Cited by 52
Serum biomarkers of neuroinflammation and blood-brain barrier leakage in amyotrophic lateral sclerosis
Cao, M. C., Cawston, E. E., Chen, G. L., Brooks, C., Douwes, J. E., McLean, D., Graham, E. S., Dragunow, M., & Scotter, E. L. (2022) · BMC Neurology · doi:10.1186/s12883-022-02730-1 · Cited by 49
Blood-spinal cord barrier leakage is independent of motor neuron pathology in ALS
Waters, S., Dieriks, B. V., Swanson, M. E. V., Zhang, Y., Grimsey, N. L., Murray, H. C., Turner, C. P., Waldvogel, H. J., Faull, R. L. M., An, J., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01244-0 · Cited by 48
Neuroimmunity dynamics and the development of therapeutic strategies for amyotrophic lateral sclerosis
Bowerman, M., Vincent, T., Scamps, F., Perrin, F. E., Camu, W., & Raoul, C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00214 · Cited by 46
Microvascular disturbance with decreased pericyte coverage is prominent in the ventral horn of patients with amyotrophic lateral sclerosis
Yamadera, M., Fujimura, H., Inoue, K., Toyooka, K., Mori, C., Hirano, H., & Sakoda, S. (2015) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2015.1011663 · Cited by 49
Glycans in Sera of Amyotrophic Lateral Sclerosis Patients and Their Role in Killing Neuronal Cells
Edri‐Brami, M., Rosental, B., Hayoun, D., Welt, M., Rosen, H., Wirguin, I., Nefussy, B., Drory, V. E., Porgador, A., & Lichtenstein, R. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035772 · Cited by 45
Complement in Neurologic Disease
Propson, N. E., Gedam, M., & Zheng, H. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-031620-113409 · Cited by 45
A characteristic ganglioside antibody pattern in the CSF of patients with amyotrophic lateral sclerosis.
Stevens, A., Weller, M., & Wiethölter, H. (1993) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.56.4.361 · Cited by 43
Neurovascular Aspects of Amyotrophic Lateral Sclerosis
Oliveira, M. C., Hernandez‐Ontiveros, D. G., Louis, M. K., Willing, A. E., Borlongan, C. V., Sanberg, P. R., Voltarelli, J. C., & Garbuzova-Davis, S. N. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-386986-9.00004-1 · Cited by 42
Evaluation of humoral immune response in adaptive immunity in ALS patients during disease progression
Saleh, I. A., Zesiewicz, T., Xie, Y., Sullivan, K. L., Miller, A. M., Kuzmin‐Nichols, N., Sanberg, P. R., & Garbuzova-Davis, S. N. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.07.011 · Cited by 36
Blood–Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies
Mohamed, L. A., Markandaiah, S. S., Bonanno, S., Pasinelli, P., & Trotti, D. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0120-6 · Cited by 35
Motor neuron diseases and amyotrophic lateral sclerosis: research progress
Rowland, L. P. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90004-x · Cited by 34
MOLECULAR APPROACHES TO AMYOTROPHIC LATERAL SCLEROSIS
Smith, R. G., & Appel, S. H. (1995) · Annual Review of Medicine · doi:10.1146/annurev.med.46.1.133 · Cited by 32
Precision Medicine in Neurology: The Inspirational Paradigm of Complement Therapeutics
Gavriilaki, M., Kimiskidis, V. Κ., & Gavriilaki, E. (2020) · Pharmaceuticals · doi:10.3390/ph13110341 · Cited by 32
Role of Complement in Motor Neuron Disease: Animal Models and Therapeutic Potential of Complement Inhibitors
Woodruff, T. M., Costantini, K. J., Taylor, S. M., & Noakes, P. G. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-78952-1_11 · Cited by 30
Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis
van Blitterswijk, M., Gulati, S., Smoot, E. W., Jaffa, M., Maher, N. E., Hyman, B. T., Ivinson, A. J., Scherzer, C. R., Schoenfeld, D., Cudkowicz, M., et al. (2011) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482968.2011.585163 · Cited by 31
TDP-43 Vasculopathy in the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis (sALS) and Frontal Cortex in sALS/FTLD-TDP
Ferrer, I., Andrés‐Benito, P., Carmona, M., Assialioui, A., & Povedano, M. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaa162 · Cited by 28
Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity
Schreiber, S., Bernal, J., Arndt, P., Schreiber, F., Müller, P., Morton, L., Braun-Dullaeus, R. C., Hernández, M. V., Duarte, R., Wardlaw, J. M., et al. (2023) · Cells · doi:10.3390/cells12060957 · Cited by 30
Targeting common disease pathomechanisms to treat amyotrophic lateral sclerosis
Faller, K. M. E., Chaytow, H., & Gillingwater, T. H. (2025) · Nature Reviews Neurology · doi:10.1038/s41582-024-01049-4 · Cited by 30
Expression of the ALS-Causing Variant hSOD1 G93A Leads to an Impaired Integrity and Altered Regulation of Claudin-5 Expression in an in Vitro Blood–Spinal Cord Barrier Model
Meister, S., Storck, S. E., Hameister, E., Behl, C., Weggen, S., Clement, A. M., & Pietrzik, C. U. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.57 · Cited by 27
Internalization of plasma proteins by cerebellar Purkinje cells
Fishman, P. S., Farrand, D. A., & Kristt, D. A. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90011-b · Cited by 27
Reduction of microhemorrhages in the spinal cord of symptomatic ALS mice after intravenous human bone marrow stem cell transplantation accompanies repair of the blood-spinal cord barrier
Eve, D. J., Steiner, G. A., Mahendrasah, A., Sanberg, P. R., Kurien, C., Thomson, A., Borlongan, C. V., & Garbuzova-Davis, S. N. (2018) · Oncotarget · doi:10.18632/oncotarget.24360 · Cited by 26
Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis
Jacob, S. M., Lee, S., Kim, S. H., Sharkey, K. A., Pfeffer, G., & Nguyen, M. D. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00991-7 · Cited by 25
C9ORF72 protein function and immune dysregulation in amyotrophic lateral sclerosis
Lai, J. D., & Ichida, J. K. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134523 · Cited by 25
Peripheral nerve atrophy together with higher cerebrospinal fluid progranulin indicate axonal damage in amyotrophic lateral sclerosis
Schreiber, S., Dębska–Vielhaber, G., Abdulla, S., Machts, J., Schreiber, F., Kropf, S., Körtvélyessy, P., Körner, S., Kollewe, K., Petri, S., et al. (2017) · Muscle & Nerve · doi:10.1002/mus.25682 · Cited by 22
Experimental immune-mediated motor neuron diseases: Models for human ALS
SMITH, R. G., Engelhardt, J. I., Tajti, J., & Appel, S. H. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90268-g · Cited by 22
Low-intensity pulsed ultrasound modulates disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis
Liu, Z., Zhang, H., Lu, K., Chen, L., Zhang, Y., Xu, Z., Zhou, H., Sun, J., Xu, M., Ouyang, Q., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114660 · Cited by 20
Amyotrophic lateral sclerosis associated with IgG anti-GalNAc-GD1a antibodies
Yamazaki, T., Suzuki, M., Irie, T., Watanabe, T., Mikami, H., & Ono, S. (2008) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2008.03.010 · Cited by 19
Immunocomplexes in rat and rabbit spinal cord after injury
Palladini, G., Grossi, M., Maleci, A., Lauro, G. M., & Guidetti, B. (1987) · Experimental Neurology · doi:10.1016/0014-4886(87)90305-0 · Cited by 18
ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis
Tang, J., Kang, Y., Zhou, Y., Li, X., Lan, J., Wu, L., Feng, X., & Peng, Y. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105315 · Cited by 16
Immunology of amyotrophic lateral sclerosis
Cashman, N. R., Gurney, M., & Antel, J. P. (1985) · Springer Seminars in Immunopathology · doi:10.1007/bf00197252 · Cited by 17
Restoring brain barriers: an innovative approach for treating neurological disorders
Lemarchant, S., Engelhardt, B., Cicchetti, F., Bix, G. J., Janus, A., Godfrin, Y., Blasco, H., Campbell, M., & Jacquet, A. D. R. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00688-z · Cited by 21
Pathophysiological Underpinnings of Extra-Motor Neurodegeneration in Amyotrophic Lateral Sclerosis: New Insights From Biomarker Studies
Reyes‐Leiva, D., Dols‐Icardo, O., Sirisi, S., Cortés‐Vicente, E., Turón‐Sans, J., de Luna, N., Blesa, R., Belbin, O., Montal, V., Alcolea, D. A., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.750543 · Cited by 18
Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS?
Alarcan, H., Ojaimi, Y. A., Lanznaster, D., Escoffre, J., Corcia, P., Vourc’h, P., Andres, C. R., Veyrat‐Durebex, C., & Blasco, H. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12071071 · Cited by 18
Neurovascular dynamics in the spinal cord from development to pathophysiology
de Almodóvar, C. R., Dupraz, S., & Bonanomi, D. (2025) · Neuron · doi:10.1016/j.neuron.2025.09.017 · Cited by 16
Integrated transcriptomic profiling reveals a STING-mediated Type II Interferon signature in SOD1-mutant amyotrophic lateral sclerosis models
Hiew, J. Y., Lim, Y.-B., Liu, H., & Ng, C. S. (2025) · Communications Biology · doi:10.1038/s42003-025-07790-w · Cited by 18
Humoral response to neurofilaments and dipeptide repeats in ALS progression
Puentes, F., Lombardi, V., Lu, C., Yildiz, Ö., Fratta, P., Isaacs, A. M., Bobeva, Y., Wuu, J., Benatar, M. G., & Malaspina, A. (2021) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51428 · Cited by 14
Association of polyclonal anti-GM1 IgM and anti-neurofilament antibodies with CSF oligoclonal bands in a young with amyotrophic lateral sclerosis
Annunziata, P., Maimone, D., & Guazzi, G. C. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1995.tb00152.x · Cited by 14
Penetration and internalization of plasma proteins in the human spinal cord
Fishman, P. S., Farrand, D. A., & Kristt, D. A. (1991) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(91)90306-r · Cited by 14
The case for complement component 5 as a target in neurodegenerative disease
Stennett, A., Friston, K., Harris, C. L., Wollman, A. J. M., Bronowska, A. K., & Madden, K. S. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2177532 · Cited by 12
Repeated Application of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells—Focus on Immunological Pathways in Patients with ALS
Baumert, B., Sobuś, A., Gołąb-Janowska, M., Paczkowska, E., Łuczkowska, K., Rogińska, D., Zawiślak, A., Milczarek, S., Osękowska, B., Pawlukowska, W., et al. (2020) · Cells · doi:10.3390/cells9081822 · Cited by 12
Ascorbate availability and neurodegeneration in amyotrophic lateral sclerosis
Kok, A. (1997) · Medical Hypotheses · doi:10.1016/s0306-9877(97)90097-9 · Cited by 12
Immunoregulatory and activated T cells in amyotrophic lateral sclerosis patients
Bartfeld, H., Dham, C., & Donnenfeld, H. (1985) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(85)80013-8 · Cited by 12
Self-citation
Safety and tolerability of tegoprubart in patients with amyotrophic lateral sclerosis: A Phase 2A clinical trial
Perrin, S., Ladha, S. S., Maragakis, N. J., Rivner, M. H., Katz, J., Genge, A. L., Olney, N. T., Lange, D. J., Heitzman, D., Bodkin, C. L., et al. (2024) · PLoS Medicine · doi:10.1371/journal.pmed.1004469 · Cited by 11
Interfering with lysophosphatidic acid receptor edg2/lpa 1 signalling slows down disease progression in SOD1‐G93A transgenic mice
Gento‐Caro, Á., Vilches‐Herrando, E., García‐Morales, V., Portillo, F., Bey, G. R., González‐Forero, D., & Moreno‐López, B. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12699 · Cited by 11
The Role of Pericytes in Amyotrophic Lateral Sclerosis
Coatti, G. C., Cavaçana, N., & Zatz, M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-16908-4_6 · Cited by 10
Decreased blood CD4+ T lymphocyte helps predict cognitive impairment in patients with amyotrophic lateral sclerosis
Yang, Y., Pan, D., Gong, Z., Tang, J., Li, Z., Ding, F., Liu, M., & Zhang, M. (2021) · BMC Neurology · doi:10.1186/s12883-021-02185-w · Cited by 10
Innate Immunity in ALS
John, D., Yuehui, J., Stephen, M., Noakes, P. G., & Woodruff, T. M. (2012) · InTech eBooks · doi:10.5772/30341 · Cited by 10
Pathophysiology of the choroid plexus in brain diseases
Mihaljević, S., Michalicová, A., Bhide, M., & Kováč, A. (2021) · General Physiology and Biophysics · doi:10.4149/gpb_2021032 · Cited by 9
Theories of Causation
Appel, S. H., Engelhardt, J. I., Smith, R. G., & Stefani, E. (1995) · Springer eBooks · doi:10.1007/978-1-4471-1871-8_11 · Cited by 9
Metabolic Reprogramming in Nerve Cells
Bhattacharya, S. (2023) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2023.18.002444 · Cited by 8
Autoimmunity and ALS: studies on antibodies to acetylcholinesterase in sera
Häggström, B., Andersen, P. M., Hjalmarsson, K., Binzer, M., & Forsgren, L. (1997) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1997.tb00079.x · Cited by 7
Patching Up the Permeability: The Role of Stem Cells in Lessening Neurovascular Damage in Amyotrophic Lateral Sclerosis
Monsour, M., Garbuzova-Davis, S. N., & Borlongan, C. V. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szac072 · Cited by 6
Disruption of blood-brain barrier in amyotrophic lateral sclerosis: an update
Brylev, L., Zakharova, M. N., Завалишин, И. А., & Gulyaeva, N. V. (2012) · Neurochemical Journal · doi:10.1134/s1819712411040064 · Cited by 7
The Neuroinflammation in the Physiopathology of Amyotrophic Lateral Sclerosis
Bowerman, M., Vincent, T., Scamps, F., Camu, W., & Raoul, C. (2013) · InTech eBooks · doi:10.5772/56489 · Cited by 5

Authors: Donnenfeld, H., Kascsak, R. J., & Bartfeld, H.
Affiliations: Saint Vincent's Catholic Medical Center (US)
Corresponding author: Donnenfeld, H.
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 1984-02
Volume: 6
Issue: 1
Pages: 51-57
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/0165-5728(84)90042-0
OpenAlex: W2012006815
Cited by: 119
References: 8
Citations by year: 2026: 2 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 15 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 8
FWCI: 2.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: amyotrophic lateral sclerosis, IgG deposits, complement C3, spinal cord, motor cortex, neuroinflammation, immune deposits, central nervous system, direct immunofluorescence
MeSH terms: Aged, Amyotrophic Lateral Sclerosis, Antibodies, Antigen-Antibody Complex, Binding, Competitive, Complement C3, Female, Fluorescent Antibody Technique, Humans, Immunoglobulin G, Male, Middle Aged, Motor Cortex, Spinal Cord

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Deposits of IgG and C3 in the spinal cord and motor cortex of ALS patients

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks