Localization of multiple dopamine receptor subtype mRNAs in human and monkey motor cortex and striatum

Huntley, G.W.; Morrison, J.H.; Prikhozhan, A.; Sealfon, S.C.

doi:10.1016/0169-328x(92)90107-m

Cited by 100Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Localization of multiple dopamine receptor subtype mRNAs in human and monkey motor cortex and striatum

Huntley, G.W., Morrison, J.H., Prikhozhan, A., Sealfon, S.C.·1992·Molecular Brain Research

DOI 10.1016/0169-328x(92)90107-m

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Abstract

Dopamine plays a critical role in motor and cognitive function through actions mediated by specific receptors, multiple subtypes of which have recently been identified. The distribution of mRNAs encoding D1, D2 and D5 receptors in the motor cortex of humans and in the motor cortex and striatum of macaque monkeys was examined using in situ hybridization. In motor cortices from both primate species, hybridization to each receptor probe resulted in numerous labeled cells throughout layers II-VI. In contrast to neocortex, in monkey striatum only the D1 and D2 receptor probes showed significant hybridization. Thus, not only does primate neocortex possess a broader representation of the dopamine receptor subtype mRNAs examined in comparison with striatum, but the unexpected presence and widespread distribution of D2 and D5 receptor mRNAs in cortex suggests that, along with D1 receptors, D2 and D5 receptors play a crucial role in the dopaminergic modulation of cognition and motor behavior, and in dopamine dysfunction associated with neuropsychiatric disorders.

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The presence of dopamine receptors on cells in primary motor cortex could provide a candidate mechanism for reward-based modulation of use-dependent plasticity.
“The presence of dopamine receptors on cells in primary motor cortex (Huntley et al., 1992; Luft and Schwarz, 2009; Ziemann et al., 1997) could provide a candidate mechanism for reward-based modulation of such use-dependent plasticity (Hosp et al., 2011).”
From Rethinking motor learning and savings in adaptation paradigms: model-free memory for successful actions combines with internal models (2011) · cites this paper as Huntley et al., 1992

The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353 · see citing works
Multiple receptors for dopamine
Kebabian, J. W., & Calne, D. B. (1979) · Nature · doi:10.1038/277093a0 · Cited by 3,742 · see citing works
D <sub>1</sub> and D <sub>2</sub> Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967 · see citing works
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
Sokoloff, P., Bruno Giros, A., Martres, M., Bouthenet, M.-L., & Schwartz, J. (1990) · Nature · doi:10.1038/347146a0 · Cited by 2,608 · see citing works
Dopamine in schizophrenia: a review and reconceptualization
Davis, K. L., Kahn, R. S., Ko, G., & Davidson, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.11.1474 · Cited by 2,021 · see citing works
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
Tol, H. H. M. V., Bunzow, J. R., Guan, H., Sunahara, R. K., Seeman, P. M., Niznik, H. B., & Civelli, O. (1991) · Nature · doi:10.1038/350610a0 · Cited by 2,015 · see citing works
Neurotransmitters and neuromodulators in the basal ganglia
Graybiel, A. M. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90104-i · Cited by 1,576 · see citing works
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500 · see citing works
A Method for Isolation of Intact, Translationally Active Ribonucleic Acid
Cathala, G., Savouret, J., Méndez, B., West, B. L., Karin, M., MARTIAL, J. A., & Baxter, J. D. (1983) · DNA · doi:10.1089/dna.1983.2.329 · Cited by 1,449 · see citing works
Dopamine (3-hydroxytyramine) and brain function.
Hornykiewicz, O. (1966) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07154-6 · Cited by 1,389 · see citing works
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
Sunahara, R. K., Guan, H., O’Dowd, B. F., Seeman, P. M., Laurier, L. G., Ng, G., George, S. R., Torchia, J., Tol, H. H. M. V., & Niznik, H. B. (1991) · Nature · doi:10.1038/350614a0 · Cited by 1,166 · see citing works
Cloning and expression of a rat D2 dopamine receptor cDNA
Bunzow, J. R., Tol, H. H. M. V., Grandy, D. K., Albert, P. R., Salon, J. A., Christie, M. J., Machida, C. A., Neve, K. A., & Civelli, O. (1988) · Nature · doi:10.1038/336783a0 · Cited by 1,116 · see citing works
Two dopamine receptors: Biochemistry, physiology and pharmacology
Stoof, J. C., & Kebabian, J. W. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90519-8 · Cited by 942 · see citing works
Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson's disease
Scatton, B., Javoy-Agid, F., Rouquier, L., Dubois, B., & Agid, Y. (1983) · Brain Research · doi:10.1016/0006-8993(83)90993-9 · Cited by 727 · see citing works
Alternative splicing directs the expression of two D2 dopamine receptor isoforms
Bruno Giros, A., Sokoloff, P., Martres, M., Riou, J., Emorine, L. J., & Schwartz, J.-C. (1989) · Nature · doi:10.1038/342923a0 · Cited by 685 · see citing works
Molecular cloning and expression of the gene for a human D1 dopamine receptor
Dearry, A., Gingrich, J. A., Falardeau, P., Fremeau, R. T., Bates, M. D., & Caron, M. G. (1990) · Nature · doi:10.1038/347072a0 · Cited by 674 · see citing works
Review: D1 dopamine receptor—the search for a function: A critical evaluation of the D1/D2 dopamine receptor classification and its functional implications
Clark, D., & White, F. J. (1987) · Synapse · doi:10.1002/syn.890010408 · Cited by 660 · see citing works
Limbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor
Gall, C. M., & Isackson, P. J. (1989) · Science · doi:10.1126/science.2549634 · Cited by 616 · see citing works
The Organization of the Cerebral Cortex.
Hawkes, A. G., Adelman, G., Dennis, S. G., Schmitt, F. O., & Warden, F. G. (1982) · Biometrics · doi:10.2307/2529917 · Cited by 583 · see citing works
Cloning and expression of human and rat Dt dopamine receptors
Zhou, Q., Grandy, D. K., Thambi, L., Kushner, J. A., Tol, H. H. M. V., Cone, R. D., Pribnow, D. G., Salon, J. A., Bunzow, J. R., & Civelli, O. (1990) · Nature · doi:10.1038/347076a0 · Cited by 562 · see citing works
Size, laminar and columnar distribution of efferent cells in the sensory‐motor cortex of monkeys
Jones, E. G., & Wise, S. P. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901750403 · Cited by 497 · see citing works
Chemical and structural analysis of the relation between cortical inputs and tyrosine hydroxylase-containing terminals in rat neostriatum
Bouyer, J. J., Park, D. H., JOH, T. H., & Pickel, V. M. (1984) · Brain Research · doi:10.1016/0006-8993(84)90239-7 · Cited by 472 · see citing works
Phenotypical characterization of the rat striatal neurons expressing the D1 dopamine receptor gene.
Moine, C. L., Normand, E., & Bloch, B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4205 · Cited by 472 · see citing works
Human dopamine D1 receptor encoded by an intronless gene on chromosome 5
Sunahara, R. K., Niznik, H. B., Weiner, D. M., Stormann, T. M., Brann, M. R., Kennedy, J. L., Gelernter, J. E., Rozmahel, R. F., Yang, Y., Israel, Y., et al. (1990) · Nature · doi:10.1038/347080a0 · Cited by 462 · see citing works
Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation.
Monsma, F. J., Mahan, L. C., McVittie, L. D., Gerfen, C. R., & Sibley, D. R. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6723 · Cited by 456 · see citing works
Dopamine synaptic complex with pyramidal neurons in primate cerebral cortex.
Goldman-Rakic, P. S., Leranth, C., Williams, S. M., Mons, N. E., & Geffard, M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.9015 · Cited by 433 · see citing works
Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamine-beta-hydroxylase
Gaspar, P., Berger, B., Febvret, A., Vigny, A., & Henry, J. P. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902790208 · Cited by 395 · see citing works
Dopaminergic A10 neurones are involved in cognitive functions
Simon, H., Scatton, B., & Moal, M. L. (1980) · Nature · doi:10.1038/286150a0 · Cited by 364 · see citing works
Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.
Tiberi, M., Jarvie, K. R., Silvia, C. P., Falardeau, P., Gingrich, J. A., Godinot, N., Bertrand, L., Yang-Feng, T. L., Fremeau, R. T., & Caron, M. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7491 · Cited by 359 · see citing works
Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission.
Fremeau, R. T., Duncan, G. E., Fornaretto, M. G., Dearry, A., Gingrich, J. A., Breese, G. R., & Caron, M. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3772 · Cited by 354 · see citing works
Organization of corticospinal neurons in the monkey
Murray, E. A., & Coulter, J. D. (1981) · Journal of Comparative Neurology · doi:10.1002/cne.901950212 · Cited by 344 · see citing works
Regional and laminar density of the dopamine innervation in adult rat cerebral cortex
Descarries, L., Lemay, B., Doucet, G., & Berger, B. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90038-8 · Cited by 341 · see citing works
The distribution of tyrosine hydroxylase-immunoreactive fibers in primate neocortex is widespread but regionally specific
Lewis, D., Campbell, M., Foote, S., Goldstein, M., & Morrison, J. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-01-00279.1987 · Cited by 325 · see citing works
Mechanisms of signal transduction at the dopamine D2 receptor
Vallar, L., & Meldolesi, J. (1989) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(89)90082-5 · Cited by 313 · see citing works
Inhibition by dopamine of (Na+ + K+)ATPase activity in neostriatal neurons through D1 and D2 dopamine receptor synergism
Bertorello, A. M., Hopfield, J. F., Aperia, A. C., & Greengard, P. (1990) · Nature · doi:10.1038/347386a0 · Cited by 282 · see citing works
Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas
Camilli, P. V. D., Macconi, D., & Spada, A. (1979) · Nature · doi:10.1038/278252a0 · Cited by 275 · see citing works
Regional and laminar distribution of the dopamine and serotonin innervation in the macaque cerebral cortex: A radioautographic study
Berger, B., Trottier, S., Verney, C., Gaspar, P., & Alvarez, C. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902730109 · Cited by 263 · see citing works
GABA Neurons in the Cerebral Cortex
Houser, C. R., Vaughn, J. E., Hendry, S. H. C., Jones, E. G., & Peters, A. (1984) · Cerebral cortex · doi:10.1007/978-1-4615-6610-6_3 · Cited by 261 · see citing works
Distribution of D2 dopamine receptor mRNA in rat brain.
Meador‐Woodruff, J. H., Mansour, A., Bunzow, J. R., Tol, H. H. M. V., Watson, S. J., & Civelli, O. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7625 · Cited by 261 · see citing works
Dopamine activation of the arachidonic acid cascade as a basis for D1D2 receptor synergism
Piomelli, D., Pilon, C., Bruno Giros, A., Sokoloff, P., Martres, M., & Schwartz, J.-C. (1991) · Nature · doi:10.1038/353164a0 · Cited by 258 · see citing works
Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.
Grandy, D. K., Zhang, Y. A., Bouvier, C., Zhou, Q. Y., Johnson, R. A., Allen, L., Buck, K. J., Bunzow, J. R., Salon, J. A., & Civelli, O. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9175 · Cited by 209 · see citing works
Localization of the mRNA for the dopamine D2 receptor in the rat brain by in situ hybridization histochemistry.
Mengod, G., Martinez-Mir, M. I., Vilaró, M. T., & Palacios, J. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.21.8560 · Cited by 164 · see citing works
Ultrastructural features of dopamine axon terminals in the anteromedial and the suprarhinal cortex of adult rat
Séguéla, P., Watkins, K. C., & Descarries, L. (1988) · Brain Research · doi:10.1016/0006-8993(88)91427-8 · Cited by 157 · see citing works
Differential effects of monocular deprivation on glutamic acid decarboxylase and type II calcium-calmodulin-dependent protein kinase gene expression in the adult monkey visual cortex [published erratum appears in J Neurosci 1991 May;11(5):following Table of Contents]
Benson, D. L., Isackson, P. J., Gall, C. M., & Jones, E. G. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-01-00031.1991 · Cited by 149 · see citing works
The output map of the primate motor cortex
LEMON, R. N. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90012-4 · Cited by 149 · see citing works
Ultrastructural Double‐Labelling Study of Dopamine Terminals and GABA‐Containing Neurons in Rat Anteromedial Cerebral Cortex
Verney, C., Alvarez, C., Geffard, M., & Berger, B. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00008.x · Cited by 147 · see citing works
Distribution of choline acetyltransferase‐, serotonin‐, dopamine‐β‐hydroxylase‐, tyrosine hydroxylase‐immunoreactive fibers in monkey primary auditory cortex
Campbell, M. J., Lewis, D. A., Foote, S. L., & Morrison, J. H. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902610204 · Cited by 132 · see citing works
The dopaminergic innervation of monkey prefrontal cortex: a tyrosine hydroxylase immunohistochemical study
Lewis, D. A., Foote, S. L., Goldstein, M., & Morrison, J. H. (1988) · Brain Research · doi:10.1016/0006-8993(88)91040-2 · Cited by 131 · see citing works
ON THE EXACT ORIGIN OF THE PYRAMIDAL TRACTS IN MAN AND OTHER MAMMALS.
Holmes, G. M., & May, W. P. (1909) · Brain · doi:10.1093/brain/32.1.1 · Cited by 127 · see citing works
Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene.
Weinshank, R. L., Adham, N., Macchi, M., Olsen, M. A., Branchek, T. A., & Hartig, P. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54590-7 · Cited by 124 · see citing works
Comparative distributions of dopamine D‐1 and D‐2 receptors in the cerebral cortex of rats, cats, and monkeys
Richfield, E. K., Young, A. B., & Penney, J. B. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902860402 · Cited by 121 · see citing works
The distribution of a dopamine D2 receptor mRNA in rat brain
Weiner, D. M., & Brann, M. R. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80960-3 · Cited by 102 · see citing works
Visualization of a dopamine D1 receptor mRNA in human and rat brain
Mengod, G., Vilaró, M. T., Niznik, H. B., Sunahara, R. K., Seeman, P. M., O’Dowd, B. F., & Palacios, J. M. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90110-j · Cited by 101 · see citing works
Morphology of pyramidal neurones in monkey motor cortex and the synaptic actions of their intracortical axon collaterals.
Ghosh, S., & Porter, R. W. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017138 · Cited by 91 · see citing works
The Significance of Dopamine for the Mode of Action of Neuroleptics and the Pathogenesis of Schizophrenia
van Praag, H. M. (1977) · The British Journal of Psychiatry · doi:10.1192/bjp.130.5.463 · Cited by 76 · see citing works
Distribution of major neurotransmitter receptors in the motor and somatosensory cortex of the rhesus monkey
Lidow, M. S., Goldman, P. S., Gallager, D. W., Geschwind, D. H., & RAKIC, P. T. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90283-2 · Cited by 61 · see citing works
Dopamine D2-receptor messenger RNA is differentially regulated by dopaminergic agents in rat anterior and neurointermediate pituitary
Autelitano, D. J., Snyder, L., Sealfon, S. C., & Roberts, J. L. (1989) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(89)90235-9 · Cited by 52 · see citing works
Distribution of dopamine D2 receptor mRNA splice variants in the rat by solution mhybridization/protection assay
Snyder, L., Roberts, J. L., & Sealfon, S. C. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90187-x · Cited by 41 · see citing works
The biochemical background to tardive dyskinesia
ANSELL, G. B. (1981) · Neuropharmacology · doi:10.1016/0028-3908(81)90001-0 · Cited by 13 · see citing works

Flagged first, then by citations

6 of the 65 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

Brodmann, 1903, Beitrage zur histologischen Lokalisation der Grosshrinrindie. I. Die Regio rolandica, J. Psychol. Neurol. Lpz., 2, 79
Feldman, 1984, Morphology of the neocortical pyramidal neuron, Vol. 1, 123
Jones, 1984, Laminar distribution of cortical efferent cells, Vol. 1, 521

Sorted by citations

Dopamine receptors: from structure to function
MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.189 · Cited by 3,633 · see citing works
GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder
Benes, F. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00225-1 · Cited by 1,082 · see citing works
“Interestingly, differential expression of mRNAs associated with the two isoforms of GAD have been reported in relation to both acute and chronic stress (Bowers et al. 1998), although in this case that for GAD67 was increased, rather than decreased as it is in schizophrenia and bipolar disorder.”
Background
Immunocytochemical localization of D1 and D2 dopamine receptors in the basal ganglia of the rat: Light and electron microscopy
Yung, K. K. L., Bolam, J. P., Smith, A. D., Hersch, S. M., Ciliax, B. J., & Levey, A. I. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00536-e · Cited by 543 · see citing works
Emerging principles of altered neural circuitry in schizophrenia
Benes, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00041-7 · Cited by 513 · see citing works
Dopamine receptors: Molecular biology, biochemistry and behavioural aspects
Jackson, D. M., & Westlind‐Danielsson, A. (1994) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)90041-8 · Cited by 479 · see citing works
Rethinking motor learning and savings in adaptation paradigms: model-free memory for successful actions combines with internal models
Huang, V. S., Haith, A., Mazzoni, P., & Krakauer, J. W. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.012 · Cited by 472 · see citing works
“The presence of dopamine receptors on cells in primary motor cortex (Huntley et al., 1992; Luft and Schwarz, 2009; Ziemann et al., 1997) could provide a candidate mechanism for reward-based modulation of such use-dependent plasticity (Hosp et al.”
Background
Neuromodulatory transmitter systems in the cortex and their role in cortical plasticity
Gu, Q. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00026-x · Cited by 518 · see citing works
Distribution of Dopamine D3 Receptor Expressing Neurons in the Human Forebrain Comparison with D2 Receptor Expressing Neurons
Gurevich, E. V. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00066-9 · Cited by 432 · see citing works
D1 dopamine receptor immunoreactivity in human and monkey cerebral cortex: predominant and extrasynaptic localization in dendritic spines.
Smiley, J. F., Levey, A. I., Ciliax, B. J., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5720 · Cited by 383 · see citing works
Dopamine in Motor Cortex Is Necessary for Skill Learning and Synaptic Plasticity
Molina-Luna, K., Pekanovic, A., Röhrich, S., Hertler, B., Schubring-Giese, M., Rioult-Pedotti, M.-S., & Luft, A. R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007082 · Cited by 350 · see citing works
“DA receptors of the D1 and D2 subtype are present in M1 in these species [11,12,13] as well as in humans [14].”
Background
D1 and D2 Receptor Gene Expression in the Rat Frontal Cortex: Cellular Localization in Different Classes of Efferent Neurons
Gaspar, P., Bloch, B., & Le Moine, C. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01092.x · Cited by 323 · see citing works
“influence the primary motor output pathway, at least in rats, although the situation could differ in primates, where both DI and D2 receptor gene expression has been demonstrated in the giant Betz cells (Huntley et al., 1992).”
Background
Dopamine, the prefrontal cortex and schizophrenia
Knable, M. B., & Weinberger, D. R. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100205 · Cited by 304 · see citing works
“…good correspondence of the overall distribution of cortical D, and D, receptor binding sites and messenger RNA (Mengod et al., 1991; Meador-Woodruff and Mansour, 1991; Huntley et al., 1992; Choi et al., 1995); however, this correspondence has not been examined at the laminar and subcellular levels.”
Background
Dopamine Receptor mRNA Expression in Human Striatum and Neocortex
Meador‐Woodruff, J. H. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00150-c · Cited by 276 · see citing works
Convergence and Plasticity of Monoaminergic Systems in the Medial Prefrontal Cortex during the Postnatal Period: Implications for the Development of Psychopathology
Benes, F. M. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.1014 · Cited by 268 · see citing works
“the somata of both pyramidal and nonpyramidal neurons probably also serve as non-random targets for these fibers in the rat mPFCx (Verney et al., 1990; Huntley et al., 1992; Benes et al., 1993; Vincent et al., 1993, 1995a; Taylor and Benes, 1996; Davidoff and Benes, 1998; Davidoff et al., 2000).”
BackgroundInfluential
D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain
Hurd, Y. L., Suzuki, M., & Sedvall, G. C. (2001) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(01)00122-3 · Cited by 262 · see citing works
PET evaluation of the dopamine system of the human brain.
Volkow, N. D., Fowler, J., Sj, G., Logan, J., Wang, G., Ding, Y., & Dewey, S. L. (1996) · PubMed · Cited by 249 · see citing works
Dopamine D5 receptors of rat and human brain
Khan, Z. U., Gutiérrez, A., Martı́n, R., Peñafiel, A., Rivera, A., & de la Calle, A. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00274-8 · Cited by 236 · see citing works
Cellular distribution of the rat D4 dopamine receptor protein in the CNS using anti-receptor antisera
Ariano, M. A., Wang, J. C. Y., Noblett, K. L., Larson, E. R., & Sibley, D. R. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01422-9 · Cited by 195 · see citing works
Postsynaptic integration of glutamatergic and dopaminergic signals in the striatum
Kötter, R. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90037-x · Cited by 186 · see citing works
Multiple Motor Learning Processes in Humans: Defining Their Neurophysiological Bases
Spampinato, D. A., & Celnik, P. A. (2020) · The Neuroscientist · doi:10.1177/1073858420939552 · Cited by 158 · see citing works
Monoaminergic Neuromodulation of Sensory Processing
Jacob, S. N., & Nienborg, H. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00051 · Cited by 143 · see citing works
Motor primitives in space and time via targeted gain modulation in cortical networks
Stroud, J. P., Porter, M. A., Hennequin, G., & Vogels, T. P. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0276-0 · Cited by 119 · see citing works
“The neuronal dynamics oscillate transiently, with a substantially lower frequency than either the fast variants or the slow variants trained by our reward-based learning rule.”
Molecular phenotype of rat striatal neurons expressing the dopamine D5 receptor subtype
Rivera, A., Alberti, I., Martín, A. B., Narváez, J. Á., de la Calle, A., & Moratalla, R. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02280.x · Cited by 131 · see citing works
“A graphical representation of the distribution of single (SS- positive) and double (SS- and D5-positive) labelled-cells is depicted in Fig.”
Background
Motor Learning Enhances Use-Dependent Plasticity
Mawase, F., Uehara, S., Bastian, A. J., & Celnik, P. A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3303-16.2017 · Cited by 124 · see citing works
“This is supported by the presence of dopamine receptors on cells in M1 (Huntley et al., 1992; Ziemann et al., 2001; Luft and Schwarz, 2009), the fact that dopaminergic medication leads to increase of UDP (Floel et al., 2008), and the finding of deficient motor cortex plasticity in Parkinson’s…”
BackgroundInfluential
What has been learnt from study of dopamine receptors in Parkinson's disease?
Hurley, M. J., & Jenner, P. G. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.12.001 · Cited by 114 · see citing works
“The distribution of dopamine D1 receptor mRNA matches that of the D1 receptor protein in most regions examined (Mengod et al., 1991, 1992; Huntley et al., 1992; Meador-Woodruff et al., 1994, 1996; Augood et al., 2000; Hurd et al., 2001; Hurley et al., 2001, 2003) with the exception of the internal…”
BackgroundMethod
Developmental and age-related changes of dopamine transporter, and dopamine D1 and D2 receptors in human basal ganglia
Meng, S. Z., Ozawa, Y., Itoh, M., & Takashima, S. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01933-2 · Cited by 112 · see citing works
Chapter I The organization and circuits of mesencephalic dopaminergic neurons and the distribution of dopamine receptors in the brain
Bentivoglio, M., & Morelli, M. (2005) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(05)80005-3 · Cited by 111 · see citing works
Dopaminergic signals in primary motor cortex
Luft, A. R., & Schwarz, S. (2009) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2009.05.004 · Cited by 92 · see citing works
“In situ hybridization for dopamine receptor mRNA has meanwhile demonstrated that D1R, D2R and D5R are expressed in human motor cortex (Huntley et al., 1992).”
Neuromodulatory Neurotransmitters Influence LTP-Like Plasticity in Human Cortex: A Pharmaco-TMS Study
Korchounov, A., & Ziemann, U. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.75 · Cited by 98 · see citing works
Monoaminergic Modulation of Motor Cortex Function
Vitrac, C., & Benoit‐Marand, M. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00072 · Cited by 84 · see citing works
“In primates, D1, D2 and D5 mRNAs are found in the motor cortex throughout layers II-V (Huntley et al., 1992).”
Background
Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes
Sriram, K., Lin, G. X., Jefferson, A. M., Roberts, J. R., Chapman, R. S., Chen, B. T., Soukup, J. M., Ghio, A. J., & Antonini, J. M. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0525-9 · Cited by 87 · see citing works
“High levels of dopamine receptor mRNAs are present in all dopaminoceptive regions of the rat brain (Nagy et al. 1978; Mengod et al. 1989; Huntley et al. 1992).”
Background
Dopamine role in learning and action inference
Bogacz, R. (2020) · eLife · doi:10.7554/elife.53262 · Cited by 79 · see citing works
Scopolamine augments C-fos and zif/268 messenger rna expression induced by the full D1 dopamine receptor agonist SKF-82958 in the intact rat striatum
Wang, J. Q., & McGinty, J. F. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00597-8 · Cited by 73 · see citing works
Distribution of dopamine D1, D2, and D5 receptor mRNAs in the monkey brain: ribonuclease protection assay analysis
Choi, W. S., Machida, C. A., & Rønnekleiv, O. K. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00038-t · Cited by 71 · see citing works
Cellular distribution of the rat D1B receptor in central nervous system using anti-receptor antisera
Ariano, M. A., Wang, J. C. Y., Noblett, K. L., Larson, E. R., & Sibley, D. R. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01219-x · Cited by 63 · see citing works
Heterogeneous distribution of D1, D2 and D5 receptor mRNAs in monkey striatum
Rappaport, M. S., Sealfon, S. C., Prikhozhan, A. V., Huntley, G. W., & Morrison, J. H. (1993) · Brain Research · doi:10.1016/0006-8993(93)90215-9 · Cited by 63 · see citing works
Distribution of 5-HT and DA receptors in primate prefrontal cortex: implications for pathophysiology and treatment
DEALMEIDA, J., Palacios, J. M., & Mengod, G. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00905-9 · Cited by 61 · see citing works
Dopamine receptor gene expression in human amygdaloid nuclei: Elevated D4 receptor mRNA in major depression
Xiang, L., Szebeni, K., Szebeni, A., Klimek, V., Stockmeier, C. A., Karolewicz, B., Kalbfleisch, J. H., & Ordway, G. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.009 · Cited by 60 · see citing works
“D5 receptor gene expression has been demonstrated in several brain regions (Bouthenet et al., 1991; Choi et al., 1995; Huntley et al., 1992; Rappaport et al., 1993), but has not been previously reported in the human amygdala.”
Contrasting effects of excitotoxic lesions of the prefrontal cortex on the behavioural response to d-amphetamine and presynaptic and postsynaptic measures of striatal dopamine function in monkeys
Wilkinson, L. S., Dias, R. S., Thomas, K. L., Augood, S. J., Everitt, B. J., Robbins, T. W., & Roberts, A. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00075-4 · Cited by 58 · see citing works
Local Application of Dopamine Inhibits Pyramidal Tract Neuron Activity in the Rodent Motor Cortex
Awenowicz, P. W., & Porter, L. L. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00078.2002 · Cited by 51 · see citing works
Characterization of subtype-specific antibodies to the human D5 dopamine receptor: studies in primate brain and transfected mammalian cells.
Bergson, C. M., Mrzljak, L., Lidow, M. S., Goldman‐Rakic, P. S., & Levenson, R. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3468 · Cited by 52 · see citing works
Chapter VI Dopamine systems in the primate brain
Lewis, D. A., & Sesack, S. R. (1997) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(97)80008-5 · Cited by 50 · see citing works
Dopaminergic modulation of primary motor cortex: From cellular and synaptic mechanisms underlying motor learning to cognitive symptoms in Parkinson’s disease
Cousineau, J., Plateau, V., Baufreton, J., & Bon-Jégo, M. L. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105674 · Cited by 49 · see citing works
Effects of l-DOPA-therapy on dopamine D2 receptor mRNA expression in the striatum of MPTP-intoxicated parkinsonian monkeys
Herrero, M. T., Augood, S. J., Asensi, H., Hirsch, É. C., Agid, Y., Obeso, J. A., & Emson, P. C. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00157-x · Cited by 48 · see citing works
D1 dopamine receptors
Huang, X., Lawler, C. P., Lewis, M. M., Nichols, D. E., & Mailman, R. B. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)48014-7 · Cited by 47 · see citing works
Heterogeneous tissue-specific transcription of dopamine receptor subtype messenger RNA in rat brain
Laurier, L. G., O’Dowd, B. F., & George, S. R. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90170-8 · Cited by 44 · see citing works
Neurotransmitters, peptides, and neural cell adhesion molecules in the cortices of normal elderly humans and alzheimer patients: a comparison
Yew, D. T. W., Li, W., Webb, S., Lai, H. W. L., & Zhang, L. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00017-5 · Cited by 43 · see citing works
Species differences in vasopressin receptor binding are evident early in development: Comparative anatomic studies in prairie and montane voles
Wang, Z., Young, L. J., Liu, Y., & Insel, T. R. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970224)378:4 · Cited by 135 · see citing works
Neurochemical alterations in schizophrenia affecting the putative receptor targets of atypical antipsychotics
Harrison, P. J. (1999) · The British Journal of Psychiatry · doi:10.1192/s0007125000298073 · Cited by 37 · see citing works
The neurobiological basis for novel experimental therapeutics in dystonia
Downs, A. M., Roman, K. M., Campbell, S. A., Pisani, A., Hess, E. J., & Bonsi, P. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104526 · Cited by 36 · see citing works
Direct Receptor Cross-Talk Can Mediate the Modulation of Excitatory and Inhibitory Neurotransmission by Dopamine
Lee, F. J. S., Wang, Y.-T., & Liu, F. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:26:2-3:245 · Cited by 34 · see citing works
Dopaminergic modulation of neuronal activity in the monkey putamen through D1 and D2 receptors during a delayed Go/Nogo task
Inase, M., Li, B., & Tanji, J. (1997) · Experimental Brain Research · doi:10.1007/s002210050217 · Cited by 34 · see citing works
“D1/D2 colocalization Several studies have demonstrated expression of mRNA for D1 and D2 receptors in the striatum by in situ hybridization (Mengod et al. 1989; Dearry et al. 1990; Weiner et al. 1991; Huntley et al. 1992; Lester et al. 1993).”
Background
Dopamine in Motor Cortex Is Necessary for Skill Learning
Molina-Luna, K., Pekanovic, A., Hertler, B., Schubring-Giese, M., Rioult-Pedotti, M.-S., & Luft, A. R. (2009) · Cited by 33 · see citing works
Regional and ultrastructural distribution of the ?8 integrin subunit in developing and adult rat brain suggests a role in synaptic function
Einheber, S., Schnapp, L. M., Salzer, J. L., Cappiello, Z. B., & Milner, T. A. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960617)370:1 · Cited by 126 · see citing works
Dopamine D1 receptor, D2 receptor, proenkephalin A and substance P gene expression in the caudate nucleus of control and schizophrenic tissue: a quantitative cellular in situ hybridisation study
Harrington, K. A., Augood, S. J., Faull, R. L. M., McKenna, P. J., & Emson, P. C. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00169-s · Cited by 32 · see citing works
THE NEUROANATOMY AND NEUROCHEMISTRY OF SCHIZOPHRENIA
Weickert, C. S., & Kleinman, J. E. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70361-0 · Cited by 31 · see citing works
Development and characterization of antibodies directed against the mouse D4 dopamine receptor
Mauger, C., Sivan, B., Brockhaus, M., Fuchs, S., Civelli, O., & Monsma, F. J. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00056.x · Cited by 30 · see citing works
Distribution of messenger RNAs for D1 dopamine receptors and DARPP-32 in striatum and cerebral cortex of the cynomolgus monkey: Relationship to D1 dopamine receptors
Brené, S., Hall, H., Lindefors, N., Karlsson, P., Halldin, C., & Sedvall, G. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00037-j · Cited by 29 · see citing works
Upregulation of striatal D2 receptors in the MPTP-treated vervet monkey is reversed by grafts of fetal ventral mesencephalon: an autoradiographic study
Elsworth, J. D., Brittan, M. S., Taylor, J. R., Sladek, J. R., Redmond, D. E., Innis, R. B., Zea‐Ponce, Y., & Roth, R. H. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00252-2 · Cited by 28 · see citing works
Ontogeny of the striatal neurons expressing the D2 dopamine receptor in humans: an in situ hybridization and receptor-binding study
Brana, C., Aubert, I., Charron, G., Pellevoisin, C., & Bloch, B. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00114-9 · Cited by 26 · see citing works
The Development of the Prefrontal Cortex: The Maturation of Neurotransmitter Systems and Their Interactions
Benes, F. M. (2015) · doi:10.1002/9780470939390.ch5 · Cited by 26 · see citing works
l-DOPA produces strong induction of c-fos messenger RNA in dopamine-denervated cortical and striatal areas of the common marmoset
Svenningsson, P., Gunne, L. M., & Andrén, P. E. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00213-x · Cited by 24 · see citing works
8,9-Dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms
Grubbs, R. A., Lewis, M. M., Vance, C. O., Gay, E. A., Jassen, A. K., Mailman, R. B., & Nichols, D. E. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.01.008 · Cited by 22 · see citing works
Dopamine induces a biphasic modulation of hypothalamic ANF neurons: a ligand concentration-dependent effect involving D5 and D2 receptor interaction
Lee, D. D., Huang, W., & LIM, A. T. W. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000601 · Cited by 18 · see citing works
Activation of the dopamine 1 and dopamine 5 receptors increase skeletal muscle mass and force production under non-atrophying and atrophying conditions
Reichart, D. L., Hinkle, R. T., Lefever, F. R., Dolan, E. T., Dietrich, J. A., Sibley, D. R., & Isfort, R. J. (2011) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-12-27 · Cited by 17 · see citing works
“The D2-like receptor group is also expressed centrally in many areas of the brain and peripherally in the pituitary, blood vessels, the heart, the adrenal gland, and the kidneys [1,4,15,17].”
Background
Enhancing Generalization of Visuomotor Adaptation by Inducing Use-dependent Learning
Lei, Y., Bao, S., Pérez, M. A., & Wang, J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.10.004 · Cited by 16 · see citing works
Dopamine receptor pharmacology
Mailman, R. B., & Huang, X. (2007) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)83004-1 · Cited by 16 · see citing works
Distribution of D1 and D5 dopamine receptors in the primate nucleus accumbens
Muly, E. C., Maddox, M., & Khan, Z. U. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.025 · Cited by 16 · see citing works
Regulation of dopamine D2 receptor mRNA expression in the olfactory tubercle by cocaine
Spyraki, C., & Sealfon, S. C. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90131-8 · Cited by 15 · see citing works
Synaptic Interactions Between Serotonergic and Dopaminergic Systems in Parkinson’s Disease
Marino, G., Campanelli, F., Natale, G., Carluccio, M. D., Servillo, F., Ghiglieri, V., & Calabresi, P. (2025) · Current Neuropharmacology · doi:10.2174/011570159x336597241217062042 · Cited by 13 · see citing works
“These neuronal subtypes show D 1 R and D 2 R [105], with their respective mRNAs [106] localized in the cell bodies.”
Neuropathological characteristics and alteration of the dopamine D2 receptor in hypoxic-ischemic basal ganglia necrosis
Meng, S. Z., Isumi, H., & Takashima, S. (1998) · Brain and Development · doi:10.1016/s0387-7604(98)00003-5 · Cited by 13 · see citing works
Continuous Dopaminergic Stimulation Improves Cortical Maladaptive Changes in Advanced Parkinson's Disease
Kolmančič, K., Župančič, N., Trošt, M., Flisar, D., Kramberger, M. G., Pirtošek, Z., & Kojović, M. (2022) · Movement Disorders · doi:10.1002/mds.29028 · Cited by 12 · see citing works
ETIOPATHOGENESIS AND TREATMENT OF PSYCHOSIS
Crow, T. J., & Harrington, C. A. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.219 · Cited by 10 · see citing works
“A recent report suggests that D 5 transcripts are also present in primate motor cortex (53).”
Background
A developmental study of the dopamine D2R receptors in the human basal ganglia and thalamus
Meng, S. Z., Obonai, T., & Takashima, S. (1998) · Early Human Development · doi:10.1016/s0378-3782(97)00071-6 · Cited by 6 · see citing works
Prenatal disruption of D1R-SynGAP complex causes cognitive deficits in adulthood
Lai, T. K. Y., Abela, A. R., Su, P., Fletcher, P. J., & Liu, F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110122 · Cited by 5 · see citing works
Alterations of Neurotransmitter Receptors in Schizophrenia: Evidence from Postmortem Studies
Kristiansen, L. V., Cowell, R. M., Biscaia, M., McCullumsmith, R. E., & Meador‐Woodruff, J. H. (2009) · Springer eBooks · doi:10.1007/978-0-387-30410-6_14 · Cited by 5 · see citing works
Distinctive Chemoanatomical and Developmental Features of the Prefrontal Dopaminergic System in Primates as Compared to Rodents
Berger, B. (1994) · Research and perspectives in neurosciences · doi:10.1007/978-3-642-85007-3_2 · Cited by 4 · see citing works
Occupancy of brain nicotinic acetylcholine receptors by nicotine doses equivalent to those obtained when smoking a cigarette
Ding, Y., Volkow, N. D., Logan, J., Garza, V., Pappas, N. R., King, P. T., & Fowler, J. S. (2000) · Synapse · doi:10.1002/(sici)1098-2396(20000301)35:3 · Cited by 25 · see citing works
Molecular mapping of striatal subdivisions in juvenile Macaca Mulata
O’Connor, J. A., Muly, E. C., & Hemby, S. E. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.11.028 · Cited by 3 · see citing works
“…and ribonuclease protection assays to examine a few transcriptional differences within the striatum on a gene by gene basis (Honrubia et al., 2000; Huntley et al., 1992; Kultas-Ilinsky et al., 1998; Mijnster et al., 1997; Rappaport et al., 1993; Richtand et al., 1995; Svenningsson et al., 1998;…”
Background
In Situ/Histological Approaches to Neurotransmitter-Specific Postmortem Brain Studies of Schizophrenia
Bachus, S. E., & Kleinman, J. E. (2002) · Neurobiological foundation of aberrant behaviors · doi:10.1007/978-1-4757-3631-1_11 · Cited by 1 · see citing works
[1] Approaches to receptor cloning
Sealfon, S. C. (1995) · Methods in neurosciences · doi:10.1016/s1043-9471(05)80031-x · Cited by 1 · see citing works
D1/D5Dopamine Agonists as Pharmacotherapy for Schizophrenia
Boyd, K. N., & Mailman, R. B. (2012) · doi:10.1002/9781118309421.ch3 · Cited by 1 · see citing works
Das dopaminerge System und schizophrene Erkrankungen
Mager, T., & Meisenzahl, E. M. (1998) · Springer eBooks · doi:10.1007/978-3-7091-6471-6_8 · Cited by 1 · see citing works
Interactions of the Dopamine, Serotonin, and GABA Systems During Childhood and Adolescence: Influence of Stress on the Vulnerability for Psychopathology
Benes, F. M. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546365.018
Use of Pavlovian conditioning techniques to study disorders of attention and learning
Stanton, M. E., & Gallagher, M. (1996) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/(sici)1098-2779(1996)2:4 · Cited by 2 · see citing works
Dopamine Receptor Presence in the Rat Area Postrema Identified by RT-PCR, Immunohistochemistry, and In Situ Hybridization
Izawa, S., Yamaai, T., Mukudai, Y., 山路, 公., Nishitani, Y., Itota, T., Matsuo, R., Takigawa, M., & Yoshiyama, M. (2007) · Journal of Oral Biosciences · doi:10.1016/s1349-0079(07)80021-1
Structure and function of dopamine receptors : ligand binding and arrestin binding
Lan, H. (2006) · doi:10.6083/m4gb2297
The influence of acute aerobic exercise on excitability and rapid plasticity in the primary motor cortex
Singh, A. M. (2016) · UWSpace (University of Waterloo)
Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes Krishnan SriramGary X. LinAmy M. JeffersonJenny R. Roberts • Rebecca S. ChapmanBean T. ChenJoleen M. SoukupAndrew J. Ghio •
Antonini, J. M. (2010)
Mutational Analysis to Define the Functional Role of the Third Intracellular Loop of D1-Class Dopaminergic Receptors
Albaker, A. B. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-5198
Synthesis and Evaluation of Tetrahydroprotoberberines as Dopamine Receptor Ligands
Gadhiya, S. (2017) · CUNY Academic Works (City University of New York)
Protein-protein Interactions Provide a Platform for G-protein-coupled Receptors to Exert Physiological and Pathological Functions in Central Nervous System: Therapeutic Potential?
Lai, T. K. Y. (2019) · TSpace (University of Toronto)
Primate Motor Cortical Activity Displays Hallmarks of a Temporal Difference Reinforcement Learning Process
Tarigoppula, V. S. A., Choi, J. S., Hessburg, J. P., McNiel, D., Marsh, B. T., & Francis, J. T. (2023) · International IEEE/EMBS Conference on Neural Engineering · doi:10.1109/ner52421.2023.10123827
“Dopamine receptors are found in M1[12] and are necessary for long-term potentiation[13], [14] in M1.”
Background
D2 Dopamine Receptor-Deficient Mutant Mice
Levine, M. S., Cepeda, C., Hurst, R. S., Ariano, M. A., Low, M. J., & Grandy, D. K. (2002) · Advances in behavioral biology · doi:10.1007/978-1-4615-0179-4_51
Relations entre les dyskinésies L-dopa induites et le récepteur D1 de la dopamine dans les neurones striataux : étude expérimentale et perspectives en thérapeutique
Berthet, A. (2010) · theses.fr (ABES) · doi:10.70675/006e1bf0z9ad7z4989za10cz71a1d9447a46
Electrophysiological characterization and functional importance of midbrain dopaminergic neurons projecting to the primary motor cortex
Plateau, V. (2023) · doi:10.70675/1388bb7fz0d46z42d7zae7bzcfb015fd41b5
Untitled work
Matelli (1998) · doi:10.1002/(sici)1096-9861(19981221)402:3
Untitled work
Andersen (2000) · doi:10.1002/1098-2396(200008)37:2
Untitled work
Lidow (1998) · doi:10.1002/(sici)1098-2396(199801)28:1

Distribution of dopamine D1, D2, and D5 receptor mRNAs in the monkey brain: ribonuclease protection assay analysis
Choi, W. S., Machida, C. A., & Rønnekleiv, O. K. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00038-t · Cited by 71 · see citing works
Heterogeneous distribution of D1, D2 and D5 receptor mRNAs in monkey striatum
Rappaport, M. S., Sealfon, S. C., Prikhozhan, A. V., Huntley, G. W., & Morrison, J. H. (1993) · Brain Research · doi:10.1016/0006-8993(93)90215-9 · Cited by 63 · see citing works
Untitled work
Lidow (1998) · doi:10.1002/(sici)1098-2396(199801)28:1
Basal ganglia and behavior: Sensory aspects of motor functioning
Arbuthnott, G. W. (1988) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(88)90100-6 · Cited by 23 · see citing works
Dopamine Receptor mRNA Expression in Human Striatum and Neocortex
Meador‐Woodruff, J. H. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00150-c · Cited by 276 · see citing works

Authors: Huntley, G. W., Morrison, J. H., Prikhozhan, A., & Sealfon, S. C.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Morrison, J.H.
ORCID: Huntley, G.W.
Morrison, J.H.
Sealfon, S.C.
Venue: Molecular Brain Research
Publisher: Elsevier BV
Published: 1992-10
Volume: 15
Issue: 3-4
Pages: 181-188
ISSN: 0169-328X (ISSN-L)
DOI: 10.1016/0169-328x(92)90107-m
OpenAlex: W2067838356
Cited by: 100
References: 65
Citations by year: 2025: 1 · 2023: 2 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 1 · 2012: 1
FWCI: 2.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01mh045212-05, 5r01mh048603-05)
National Institute of Mental Health (MH 45212, MH48603)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: dopamine receptors, dopamine D1 receptor, dopamine D2 receptor, dopamine D5 receptor, motor cortex, striatum, macaque, human brain, neuropsychiatric disorders
MeSH terms: Aged, Aged, 80 and over, Animals, Corpus Striatum, Female, Humans, Macaca fascicularis, Male, Motor Cortex, Receptors, Dopamine, RNA, Messenger, RNA Probes, In Situ Hybridization

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Localization of multiple dopamine receptor subtype mRNAs in human and monkey motor cortex and striatum

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