D1 and D2 Receptor Gene Expression in the Rat Frontal Cortex: Cellular Localization in Different Classes of Efferent Neurons

Gaspar, Patricia; Bloch, Bertrand; Le Moine, Catherine

doi:10.1111/j.1460-9568.1995.tb01092.x

Cited by 323Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

D1 and D2 Receptor Gene Expression in the Rat Frontal Cortex: Cellular Localization in Different Classes of Efferent Neurons

Gaspar, Patricia, Bloch, Bertrand, Le Moine, Catherine·1995·European Journal of Neuroscience

DOI 10.1111/j.1460-9568.1995.tb01092.x

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Abstract

The dopaminergic input to the frontal cortex has an important role in motor and cognitive functions. These effects are mediated by dopamine receptors both of type D1 and of type D2, although the neural circuits involved are not completely understood. We used in situ hybridization to determine the cellular localization of D1 and D2 receptor mRNAs in the rat frontal cortex. Retrograde tracing was used in the same animals to identify the main cortical efferent populations. Fluorogold was injected into the different cortical targets of the frontal cortex and sections were hybridized with D1 and D2 35 S‐labelled cRNA probes. D1 and D2 mRNA‐containing neurons were present in all the cortical areas investigated, with greater expression in the medial prefrontal, insular and cingulate cortexes and lower expression in the motor and parietal cortexes. Neurons containing D1 mRNA were most abundant in layer Vlb; they were also present in layers Vla and V of all cortical layers and in layer II of the medial prefrontal, cingulate and insular areas. Double labelling with fluorogold demonstrated that D1 mRNA was present in corticocortical, corticothalamic and corticostriatal neurons. Neurons containing D2 mRNA were essentially restricted to layer V, but only in corticostriatal and corticocortical neurons. Neither D1 nor D2 mRNA was found in corticospinal or corticopontine neurons. The present results demonstrate that D1 and D2 receptor genes are expressed in efferent cortical populations, with higher expression for D1. In spite of an overlap in some cortical layers, the expression of D1 and D2 receptor genes is specific for different categories of pyramidal neurons.

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Receptors, transporters as well as synthesizing enzymes are already expressed (~E10 rodent and week 4-5 human) even when the actual axonal projections have not yet arrived in the PFC.
“Receptors, transporters as well as synthesizing enzymes are already expressed (~E10 rodent and week 4–5 human) even when the actual axonal projections have not yet arrived in the PFC [236–240].”
From Development of prefrontal cortex (2022) · cites this paper as [240]

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Authors: Gaspar, P., Bloch, B., & Le Moine, C.
Affiliations: Centre National de la Recherche Scientifique (FR)
ORCID: Bloch, Bertrand
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 1995-05
Volume: 7
Issue: 5
Pages: 1050-1063
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/j.1460-9568.1995.tb01092.x
OpenAlex: W2037799143
Cited by: 323
References: 52
Citations by year: 2026: 2 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 19 · 2020: 9 · 2019: 13 · 2018: 15 · 2017: 12 · 2016: 8 · 2015: 5 · 2014: 12 · 2013: 15 · 2012: 9
FWCI: 2.66
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3994 d)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: dopamine D1 receptor, dopamine D2 receptor, frontal cortex, receptor mRNA expression, corticostriatal neurons, corticothalamic neurons, pyramidal neurons, cortical layers, medial prefrontal cortex, cingulate cortex, insula, dopaminergic input
MeSH terms: Animals, Autoradiography, Brain Mapping, Efferent Pathways, Frontal Lobe, Male, Neurons, RNA, Messenger, Gene Expression, Rats, Wistar, In Situ Hybridization, Receptors, Dopamine D1, Receptors, Dopamine D2, RNA, Complementary, Rats

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D1 and D2 Receptor Gene Expression in the Rat Frontal Cortex: Cellular Localization in Different Classes of Efferent Neurons

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