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Cited by 65Regulation of Appetite and ObesityLipid metabolism and biosynthesisPancreatic function and diabetes

Metabolic effects of vasopressin infusion in the starved rat. Reversal of ketonaemia

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Rofe, A M, Williamson, D H·1983·Biochemical Journal
DOI 10.1042/bj2120231PMC PMC1152034
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Abstract

The effects of vasopressin on the metabolism of starved rats were investigated by using a constant-infusion regimen (50 pmol/kg body wt. per min, after an initial loading dose of 150 pmol/kg body wt.). 2. Blood ketone bodies decreased by 50% in 10 min, and this was accompanied by a 60% decrease in the plasma non-esterified fatty acids. 3. Blood glucose increased by 0.9 mM within 5 min and decreased to control values over the 40 min infusion. Small increases in lactate and pyruvate also occurred. 4. Plasma insulin was not increased by vasopressin infusion. 5. The net decrease in blood ketone bodies caused by vasopressin was similar when somatostatin was infused simultaneously (1 nmol/kg body wt. per min). 6. Hepatic ketone bodies were significantly decreased by vasopressin, as was the 3-hydroxybutyrate/acetoacetate ratio. A small increase in the hepatic concentration of several glycolytic intermediates also occurred. 7. Vasopressin did not decrease the ketonaemia produced by infusions of octanoate or long-chain triacylglycerol in rats that had been pre-treated with the anti-lipolytic agent 3,5-dimethylpyrazole. 8. In comparison with vasopressin, the infusion of adrenaline or glucose had much smaller effects in decreasing the ketonaemia of starvation, despite the 4-fold increase in plasma insulin, at 10 min, with the glucose infusion. 9. The primary metabolic effect of vasopressin in the starved rat appears to be that of decreased supply of non-esterified fatty acid to the liver. It is suggested that vasopressin has a direct anti-lipolytic effect in adipose tissue.

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Research works printed but not linked: 14

  1. Adam, H. (1963) in Methods in Enzymatic Analysis (Bergmeyer, H. U., ed.), pp. 573-577, Academic Press, New York and London
  2. Bergmeyer, H. U. & Bernt, E. (1963) in Methods in Enzymatic Analysis (Bergmeyer, H. U., ed.), pp. 324-327, Academic Press, New York and London
  3. Bernt, E. & Bergmeyer, H. U. (1963) in Methods in Enzymatic Analysis (Bergmeyer, H. U., ed.), pp. 384-388, Academic Press, New York and London
  4. Burrin, J. M., Farrer, M. & Alberti, K. G. M. M. (1982) Biochem. Soc. Trans. 10, 274-275
  5. Czok, R. & Eckert, L. (1963) in Methods in Enzymatic Analysis (Bergmeyer, H. U., ed.), pp. 229-233, Academic Press, New York and London
  6. Dagley, S. (1963) in Methods in Enzymatic Analysis (Bergmeyer, H. U., ed.), pp. 313-317, Academic Press, New York and London
  7. Denton, R. M., McCormack, J. G. & Oviasu, 0. A. (1981) in Short-Term Regulation of Hepatic Metab- olism (Hue, L. & Van de Werve, G., eds.), pp. 159-174, Elsevier/North-Holland Biomedical Press, Amsterdam, New York and London
  8. Hohorst, H. J. (1963a) in Methods in Enzymatic Analysis (Bergmeyer, H. U., ed.), pp. 215-219, Academic Press, New York and London
  9. Hohorst, H. J. (1963b) in Methods in Enzymatic Analysis (Bergmeyer, H. U., ed.), pp. 328-332, Academic Press, New York and London
  10. Pfleiderer, G. (1963) in Methods of Enzymatic Analysis (Bergmeyer, H. U., ed.), pp. 381-383, Academic Press, New York and London
  11. Siess, E. A., Brock, D. G. & Wieland, 0. H. (1978) Biochem. Soc. Trans. 6, 1139-1144
  12. Slein, M. W. (1963) in Methods in Enzymatic Analysis (Bergmeyer, H. U., ed.), pp. 117-123, Academic Press, New York and London
  13. Sugden, M. C. & Williamson, D. H. (1981) in Short- Term Regulation of Hepatic Metabolism (Hue, L. & Van de Werve, G., eds.), pp. 291-310, Elsevier/ North-Holland Biomedical Press, Amsterdam, New York and London
  14. Williamson, D. H. (1979) Biochem. Soc. Trans. 7, 1313-1321

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Authors
Rofe, A. M., & Williamson, D. H.
Affiliations
South Australia Pathology (AU)
Venue
Biochemical Journal
Publisher
Portland Press Ltd.
Published
1983-04-15
Volume
212
Issue
1
Pages
231-239
ISSN
0264-6021 (ISSN-L)
DOI
10.1042/bj2120231
PMC
PMC1152034
OpenAlex
W1694055304
Cited by
65
References
47
Citations by year
2026: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 1 · 2019: 3 · 2017: 1 · 2016: 3 · 2015: 1 · 2013: 1 · 2012: 1
FWCI
2.39
Type
journal article
Language
en
Open access
Locations
  • Biochemical Journal (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords
vasopressin, starvation, ketonaemia, ketone bodies, free fatty acids, hepatic ketogenesis, adipose tissue lipolysis, somatostatin, insulin, epinephrine, glucose infusion, beta-hydroxybutyrate, acetoacetate, glycolytic intermediates, octanoate, 3,5-dimethylpyrazole
MeSH terms
Animals, Epinephrine, Glucose, Infusions, Parenteral, Ketone Bodies, Liver, Male, Rats, Inbred Strains, Somatostatin, Starvation, Vasopressins, Lipid Metabolism, Rats

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