Studies of the Nature of the Interaction between Vasopressin and Corticotropin-Releasing Factor on Adrenocorticotropin Release in the Rat*
Abstract
Arginine-vasopressin (AVP) acts on vasoconstriction and diuresis through two different types of receptors (V1 and V2, respectively). Since AVP also modifies ACTH release, we have attempted to determine which class of receptors mediates the capacity of AVP to increase ACTH secretion and to potentiate the effect of corticotropin-releasing factor (CRF) on the pituitary using two AVP antagonists: [1-deaminopenicillamine-2-(O-methyl)tyrosine]arginine-vasopressin [dPTyr(Me)-AVP], which blocks V1 receptors, and [1-beta-mercapto-beta,beta-cyclopentamethylene propionic acid)2-D-leucine-4-valine]arginine vasopressin [d(CH2)5DLeuValAVP], which interferes with V2 receptors. dPTyr(Me)AVP, but not d(CH2)5DLeuValAVP, inhibited the ACTH-releasing as well as the CRF-potentiating effects of both AVP and its antidiuretic analog [1-deamino-8-D-arginine]vasopressin (dDAVP). These results suggest that the actions of AVP and dDAVP on the corticotrophs is primarily mediated through V1 (pressor-like) receptors.
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AVP can be co-expressed with CRH in the rat PVN and co-secreted with CRH to enhance CRH's secretagogue activity at the pituitary.
“AVP can be co-expressed with CRH in the rat PVN, and can be co-secreted with CRH where it acts at the pituitary to enhance the secretagouge activity of CRH (Rivier, Rivier, Mormede, & Vale, 1984; Rivier & Vale, 1983, 1985).”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Rivier, Rivier, Mormede, & Vale, 1984
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CRF and CRF receptors: role in stress responsivity and other behaviors
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A V1-like receptor mediates vasopressin-induced flank marking behavior in hamster hypothalamus
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- Authors
- RIVIER, C., RIVIER, J., MORMEDE, P., & VALE, W.
- Affiliations
- Inserm (FR)
- ORCID
- VALE, WYLIE
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1984-09
- Volume
- 115
- Issue
- 3
- Pages
- 882-886
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2165207824
- Cited by
- 154
- References
- 1
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- vasopressin, corticotropin-releasing factor, V1 vasopressin receptor, V2 receptor, desmopressin, pituitary corticotrophs, receptor antagonists, ACTH secretion
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Cells, Cultured, Corticotropin-Releasing Hormone, Deamino Arginine Vasopressin, Drug Synergism, Male, Pituitary Gland, Anterior, Rats, Inbred Strains, Rats
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