The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.
Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease
Abstract
Factors which limit the interpretation of studies of aging brain include: secular trends, species and strain differences, effects of tissue processing, and bias which may be introduced at many levels of an experimental design. With these limitations considered, evidence is reviewed regarding neuron numbers and dendritic extent in normally aging rodent, monkey and human brain and in Alzheimer's disease. It is concluded that neuron loss and change in dendritic extent in normal aging are regionally specific, and that corresponding brain regions do not always change in similar ways in rodents and primates. It is suggested that such differences may, in part, be due to inconsistent definitions of 'aged' among species. In Alzheimer's disease there is excess neuron loss and dendritic regression in some, but not all, brain regions. Measures of the morphological substrates of brain function show appreciable overlap between AD and control groups. It is hypothesized that the static, post-mortem status of brain morphology may not adequately reflect the functional capabilities of the dynamic morphology of the living brain.
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“Neuron loss is a basic and fundamental feature in the pathogenesis of AD [18,19], starting already at preclinical stages when the neuropathological hallmarks are not yet present [20].”
From Neuron Loss in Alzheimer’s Disease: Translation in Transgenic Mouse Models (2020) · cites this paper as [18]
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Items 201–203 of 203
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Research works printed but not linked: 9
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Cell death during development of the nervous system
Oppenheim, R. W. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002321 · Cited by 3,084
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
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“Controversy also exists about whether aging and AD represent a neuropathological continuum or are dichotomous (Terry et al., 1981, 1987; Coleman and Flood, 1987; West et al., 1994).”
BackgroundLife and Death of Neurons in the Aging Brain
Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267
Self-citationDickerson, B. C., Bakkour, A., Salat, D. H., Feczko, E., Pacheco, J., Greve, D. N., Grodstein, F., Wright, C. I., Blacker, D., Rosas, H. D., et al. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn113 · Cited by 1,153
Metadata
- Authors
- Coleman, P. D., & Flood, D. G.
- Affiliations
- University of Rochester Medicine (US)
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1987-11
- Volume
- 8
- Issue
- 6
- Pages
- 521-545
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1966157184
- Cited by
- 772
- References
- 203
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 10 · 2023: 15 · 2022: 7 · 2021: 10 · 2020: 15 · 2019: 13 · 2018: 8 · 2017: 2 · 2016: 9 · 2015: 15 · 2014: 10 · 2013: 16 · 2012: 11
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG01121, AG03644)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neuronal loss, normal brain aging, Alzheimer's disease, rodent brain, primate brain
- MeSH terms
- Aging, Alzheimer Disease, Amygdala, Animals, Brain, Cerebellum, Cerebral Cortex, Dendrites, Hippocampus, Humans, Neurons, Species Specificity
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