The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.
Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease
Abstract
Factors which limit the interpretation of studies of aging brain include: secular trends, species and strain differences, effects of tissue processing, and bias which may be introduced at many levels of an experimental design. With these limitations considered, evidence is reviewed regarding neuron numbers and dendritic extent in normally aging rodent, monkey and human brain and in Alzheimer's disease. It is concluded that neuron loss and change in dendritic extent in normal aging are regionally specific, and that corresponding brain regions do not always change in similar ways in rodents and primates. It is suggested that such differences may, in part, be due to inconsistent definitions of 'aged' among species. In Alzheimer's disease there is excess neuron loss and dendritic regression in some, but not all, brain regions. Measures of the morphological substrates of brain function show appreciable overlap between AD and control groups. It is hypothesized that the static, post-mortem status of brain morphology may not adequately reflect the functional capabilities of the dynamic morphology of the living brain.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Neuron loss is a basic and fundamental feature in the pathogenesis of AD [18,19], starting already at preclinical stages when the neuropathological hallmarks are not yet present [20].”
From Neuron Loss in Alzheimer’s Disease: Translation in Transgenic Mouse Models (2020) · cites this paper as [18]
Citations
Cites
The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
Whitehouse, P. J., Price, D. L., Clark, A. W., Coyle, J. T., & DeLong, M. R. (1981) · Annals of Neurology · doi:10.1002/ana.410100203 · Cited by 1,736
Pearson, R. C., Esiri, M. M., Hiorns, R. W., Wilcock, G. K., & Powell, T. P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.13.4531 · Cited by 987
The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia
Swaab, D. F., Fliers, E., & Partiman, T. S. (1985) · Brain Research · doi:10.1016/0006-8993(85)91350-2 · Cited by 847
Arendt, T., Bigl, V., Arendt, A., & Tennstedt, A. (1983) · Acta Neuropathologica · doi:10.1007/bf00697388 · Cited by 817
Some morphometric aspects of the brain in senile dementia of the alzheimer type
Terry, R. D., Peck, A., DeTeresa, R., Schechter, R., & Horoupian, D. S. (1981) · Annals of Neurology · doi:10.1002/ana.410100209 · Cited by 801
Neocortical cell counts in normal human adult aging
Terry, R. D., DeTeresa, R. M., & Hansen, L. A. (1987) · Annals of Neurology · doi:10.1002/ana.410210603 · Cited by 686
Bondareff, W., Mountjoy, C. Q., & Roth, M. (1982) · Neurology · doi:10.1212/wnl.32.2.164 · Cited by 683
Research works printed but not linked: 9
- Bottcher, 1975, Morphology of the basal ganglia in Parkinson's disease, Acta Neurol Scand, 52, 1
- Coleman, 1983, Dendritic extent of layer II pyramids in entorhinal cortex of aging F344 rat, Soc Neurosci Abstr, 9, 930
- Flood, 1983, Age-related changes in dendritic extent of neurons in supraoptic nucleus of F344 rats, Soc Neurosci Abstr, 9, 930
- Flood, 1985, Dendrites of the subiculum in human aging and Alzheimer's disease, Soc Neurosci Abstr, 11, 896
- Gundersen, 1985, Stereology of arbitrary particles: A review of the unbiased estimators of number and sizes, 1
- Lockhart, 1984, Topographical loss of locus coeruleus cells in Alzheimer's disease, Soc Neurosci Abstr, 10, 995
- Pysh, 1980, Purkinje cell dendrites in aged rats: A morphometric Golgi analysis, Soc Neurosci Abstr, 6, 281
- Sandoz, 1977, Age-related loss of nerve cells from the human inferior olive, and unchanged volume of its gray matter, IRCS Med Sci, 5, 376
- Whitehouse, 1983, Integrity of the nucleus basalis of Meynert in normal aging, Neurology, 33, 159
Cited by
Sorted by citations
Cell death during development of the nervous system
Oppenheim, R. W. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002321 · Cited by 3,084
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
Gómez-Isla, T., Price, J. L., McKeel Jr., D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04491.1996 · Cited by 1,796
“Controversy also exists about whether aging and AD represent a neuropathological continuum or are dichotomous (Terry et al., 1981, 1987; Coleman and Flood, 1987; West et al., 1994).”
BackgroundLife and Death of Neurons in the Aging Brain
Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267
Self-citationDickerson, B. C., Bakkour, A., Salat, D. H., Feczko, E., Pacheco, J., Greve, D. N., Grodstein, F., Wright, C. I., Blacker, D., Rosas, H. D., et al. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn113 · Cited by 1,153
Unbiased stereological estimation of the number of neurons in the human hippocampus
West, M. J., & Gundersen, H. J. G. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960102 · Cited by 1,153
Hippocampal damage associated with prolonged glucocorticoid exposure in primates
Sapolsky, R., Uno, H., Rebert, C., & Finch, C. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-09-02897.1990 · Cited by 1,103
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
Phillips, H. S., Hains, J. M., Armanini, M., Laramee, G. R., Johnson, S. A., & Winslow, J. W. (1991) · Neuron · doi:10.1016/0896-6273(91)90273-3 · Cited by 921
Neuropathogenesis of Delirium: Review of Current Etiologic Theories and Common Pathways
Maldonado, J. R. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.09.005 · Cited by 745
Berg, L., McKeel, D. W., Miller, J. P., Storandt, M., Rubin, E. H., Morris, J. C., Baty, J., Coats, M., Norton, J., Goate, A. M., et al. (1998) · Archives of Neurology · doi:10.1001/archneur.55.3.326 · Cited by 657
Delirium pathophysiology: An updated hypothesis of the etiology of acute brain failure
Maldonado, J. R. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4823 · Cited by 617
Wellman, C. L. (2001) · Journal of Neurobiology · doi:10.1002/neu.1079 · Cited by 594
Butterfield, D. A., Reed, T., Newman, S. F., & Sultana, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.037 · Cited by 564
Quantitative assessment of cortical synaptic density in Alzheimer's disease
Scheff, S. W., DeKosky, S. T., & Price, D. A. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90059-9 · Cited by 446
Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies
Tromp, D., Dufour, A., Lithfous, S., Pebayle, T., & Després, O. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.08.006 · Cited by 390
Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline
Shi, Q., Colodner, K. J., Matousek, S. B., Merry, K., Hong, S., Kenison, J. E., Frost, J. L., Le, K. X., Li, S., Dodart, J.-C., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1698-15.2015 · Cited by 368
Convit, A., de Asis, J., de Leon, M. J., Tarshish, C. Y., De Santi, S., & Rusinek, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00107-4 · Cited by 359
White matter damage on diffusion tensor imaging correlates with age-related cognitive decline
Charlton, R. A., Barrick, T. R., McIntyre, D. J., Shen, Y., O'Sullivan, M., Howe, F. A., Clark, C. A., Morris, R. G., & Markus, H. S. (2006) · Neurology · doi:10.1212/01.wnl.0000194256.15247.83 · Cited by 354
Synaptic slaughter in Alzheimer's disease
Coleman, P. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.001 · Cited by 351
Self-citationThe pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer’s disease.
Reisberg, B., Prichep, L., Mosconi, L., John, E. R., Glodzik‐Sobanska, L., Boksay, I., Monteiro, I., Torossian, C., Vedvyas, A., Ashraf, N., et al. (2008) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2007.11.017 · Cited by 312
Cummings, B. J., Pike, C. J., Shankle, R., & Cotman, C. W. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00170-4 · Cited by 305
Frodl, T., Jäger, M., Smajstrlova, I., Born, C., Bottlender, R., Palladino, T., Reiser, M., Möller, H.-J., & Meisenzahl, E. M. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0840 · Cited by 279
Sultana, R., Perluigi, M., & Butterfield, D. A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0517-0 · Cited by 215
Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients
Mullaart, E., Boerrigter, M. E. T. I., Ravid, R., Swaab, D. F., & Vijg, J. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90542-8 · Cited by 201
Reed, T. T., Pierce, W. M., Markesbery, W. R., & Butterfield, D. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.009 · Cited by 190
Anderton, B. H. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00426-2 · Cited by 187
Age-related changes in brain activation during a delayed item recognition task
Zarahn, E., Rakitin, B., Abela, D., Flynn, J., & Stern, Y. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.03.002 · Cited by 179
Geula, C. (1998) · Neurology · doi:10.1212/wnl.51.1_suppl_1.s18 · Cited by 184
NMDA Receptor Blockade Alters Stress-Induced Dendritic Remodeling in Medial Prefrontal Cortex
Martin, K. P., & Wellman, C. L. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr021 · Cited by 138
Morgan, T. E., Rozovsky, I., Goldsmith, S. K., Stone, D. J., Yoshida, T., & Finch, C. E. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00120-2 · Cited by 126
Preserved Number of Entorhinal Cortex Layer II Neurons in Aged Macaque Monkeys
Gazzaley, A. H., Thakker, M. M., Hof, P. R., & Morrison, J. H. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00112-7 · Cited by 122
The more physical inactivity, the more agitation in dementia
Scherder, E. J. A., Bogen, T., Eggermont, L. H. P., Hamers, J. P. H., & Swaab, D. F. (2010) · International Psychogeriatrics · doi:10.1017/s1041610210001493 · Cited by 121
Aged Non‐Human Primates: An Animal Model of Age‐Associated Neurodegenerative Disease
Price, D. L., Martin, L. J., Sisodia, S. S., Wagster, M. V., Koo, E. H., Walker, L. C., Koliatsos, V. E., & Cork, L. C. (1991) · Brain Pathology · doi:10.1111/j.1750-3639.1991.tb00672.x · Cited by 100
Sultana, R., Reed, T., Perluigi, M., Coccia, R., Pierce, W. M., & Butterfield, D. A. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00065.x · Cited by 87
Age-related neuronal loss in the rat brain starts at the end of adolescence
Morterá, P., & Herculano-Houzel, S. (2012) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2012.00045 · Cited by 79
Neuron Loss in Alzheimer’s Disease: Translation in Transgenic Mouse Models
Wirths, O., & Zampar, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218144 · Cited by 75
“Neuron loss is a basic and fundamental feature in the pathogenesis of AD [18,19], starting already at preclinical stages when the neuropathological hallmarks are not yet present [20].”
BackgroundDe Santi, S., de Leon, M. J., Convit, A., Tarshish, C., Rusinek, H., Tsui, W. H., Sinaiko, E., Wang, G.-J., Bartlet, E., & Volkow, N. (1995) · Psychiatric Quarterly · doi:10.1007/bf02238755 · Cited by 74
Wu, B.-S., Zhang, Y.-R., Li, H.-Q., Kuo, K., Chen, S.-D., Dong, Q., Liu, Y., & Yu, J.-T. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01599-x · Cited by 69
Synaptic reorganization in scaled networks of controlled size.
Wilson, N. R., Ty, M. T., Ingber, D. E., Sur, M., & Liu, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3863-07.2007 · Cited by 52
Dendritic and Synaptic Protection: Is It Enough to Save the Retinal Ganglion Cell Body and Axon?
Morquette, J. B., & Di Polo, A. (2008) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0b013e318177edf0 · Cited by 51
Human amygdala involvement in Alzheimer's disease revealed by stereological and dia‐PASEF analysis
Gonzalez‐Rodriguez, M., Villar‐Conde, S., Astillero‐Lopez, V., Villanueva‐Anguita, P., Ubeda‐Banon, I., Flores‐Cuadrado, A., Martinez‐Marcos, A., & Saiz‐Sanchez, D. (2023) · Brain Pathology · doi:10.1111/bpa.13180 · Cited by 36
Staging Neurodegenerative Disorders: Structural, Regional, Biomarker, and Functional Progressions
Archer, T., Kostrzewa, R. M., Beninger, R. J., & Palomo, T. (2011) · Neurotoxicity Research · doi:10.1007/s12640-010-9190-2 · Cited by 34
Mechanisms of Neuron Loss in Alzheimer’s Disease
Mukhin, V. N., Pavlov, K. I., & Klimenko, V. M. (2017) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-017-0427-x · Cited by 27
Senescence in aging and disorders of the central nervous system
Swenson, B. L., Meyer, C. F., Bussian, T. J., & Baker, D. J. (2019) · Translational Medicine of Aging · doi:10.1016/j.tma.2019.01.002 · Cited by 24
Konsolaki, E., & Skaliora, I. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu019 · Cited by 9
Metadata
- Authors
- Coleman, P. D., & Flood, D. G.
- Affiliations
- University of Rochester Medicine (US)
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1987-11
- Volume
- 8
- Issue
- 6
- Pages
- 521-545
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1966157184
- Cited by
- 772
- References
- 203
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 10 · 2023: 15 · 2022: 7 · 2021: 10 · 2020: 15 · 2019: 13 · 2018: 8 · 2017: 2 · 2016: 9 · 2015: 15 · 2014: 10 · 2013: 16 · 2012: 11
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG01121, AG03644)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neuronal loss, normal brain aging, Alzheimer's disease, rodent brain, primate brain
- MeSH terms
- Aging, Alzheimer Disease, Amygdala, Animals, Brain, Cerebellum, Cerebral Cortex, Dendrites, Hippocampus, Humans, Neurons, Species Specificity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
