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Cited by 772Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.

Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease

Coleman, Paul D., Flood, Dorothy G.·1987·Neurobiology of Aging
DOI 10.1016/0197-4580(87)90127-8
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Abstract

Factors which limit the interpretation of studies of aging brain include: secular trends, species and strain differences, effects of tissue processing, and bias which may be introduced at many levels of an experimental design. With these limitations considered, evidence is reviewed regarding neuron numbers and dendritic extent in normally aging rodent, monkey and human brain and in Alzheimer's disease. It is concluded that neuron loss and change in dendritic extent in normal aging are regionally specific, and that corresponding brain regions do not always change in similar ways in rodents and primates. It is suggested that such differences may, in part, be due to inconsistent definitions of 'aged' among species. In Alzheimer's disease there is excess neuron loss and dendritic regression in some, but not all, brain regions. Measures of the morphological substrates of brain function show appreciable overlap between AD and control groups. It is hypothesized that the static, post-mortem status of brain morphology may not adequately reflect the functional capabilities of the dynamic morphology of the living brain.

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Crossref · 10.1016/0197-4580(87)90127-8

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203 of 203 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 9

  1. Bottcher, 1975, Morphology of the basal ganglia in Parkinson's disease, Acta Neurol Scand, 52, 1
  2. Coleman, 1983, Dendritic extent of layer II pyramids in entorhinal cortex of aging F344 rat, Soc Neurosci Abstr, 9, 930
  3. Flood, 1983, Age-related changes in dendritic extent of neurons in supraoptic nucleus of F344 rats, Soc Neurosci Abstr, 9, 930
  4. Flood, 1985, Dendrites of the subiculum in human aging and Alzheimer's disease, Soc Neurosci Abstr, 11, 896
  5. Gundersen, 1985, Stereology of arbitrary particles: A review of the unbiased estimators of number and sizes, 1
  6. Lockhart, 1984, Topographical loss of locus coeruleus cells in Alzheimer's disease, Soc Neurosci Abstr, 10, 995
  7. Pysh, 1980, Purkinje cell dendrites in aged rats: A morphometric Golgi analysis, Soc Neurosci Abstr, 6, 281
  8. Sandoz, 1977, Age-related loss of nerve cells from the human inferior olive, and unchanged volume of its gray matter, IRCS Med Sci, 5, 376
  9. Whitehouse, 1983, Integrity of the nucleus basalis of Meynert in normal aging, Neurology, 33, 159

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Metadata

Authors
Coleman, P. D., & Flood, D. G.
Affiliations
University of Rochester Medicine (US)
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
1987-11
Volume
8
Issue
6
Pages
521-545
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/0197-4580(87)90127-8
OpenAlex
W1966157184
Cited by
772
References
203
Citations by year
2026: 3 · 2025: 4 · 2024: 10 · 2023: 15 · 2022: 7 · 2021: 10 · 2020: 15 · 2019: 13 · 2018: 8 · 2017: 2 · 2016: 9 · 2015: 15 · 2014: 10 · 2013: 16 · 2012: 11
FWCI
5.50
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG01121, AG03644)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neuronal loss, normal brain aging, Alzheimer's disease, rodent brain, primate brain
MeSH terms
Aging, Alzheimer Disease, Amygdala, Animals, Brain, Cerebellum, Cerebral Cortex, Dendrites, Hippocampus, Humans, Neurons, Species Specificity

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