Cited by 43Rabies epidemiology and controlVirology and Viral DiseasesViral Infections and Immunology Research

The protective role of humoral neutralizing antibody in the NIH potency test for rabies vaccines

Wunderli, Peter S., Shaddock, John H., Scott Schmid, D., Miller, Timothy J., Baer, George M.·1991·Vaccine

Abstract

Intraperitoneal vaccination of mice with rabies vaccine results in both dosage-dependent rabies virus neutralizing antibody titres and protection from lethal intracerebral (i.c.) challenge with fixed strain CVS rabies virus. Pre-exposure adoptive intravenous transfer of naive or immune cells did not significantly protect naive Balb/c mice from lethal i.c. CVS challenge, but immune serum and anti-rabies glycoprotein monoclonal antibodies (individually and in combination) did confer significant protection when administered before or up to 24 h after lethal i.c. rabies virus challenge.

Integrity signals

Registry

Crossref · 10.1016/0264-410x(91)90188-c

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32 of 32 references verified0 citation errors · 0 not checkable

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Authors
Wunderli, P. S., Shaddock, J. H., Scott Schmid, D., Miller, T. J., & Baer, G. M.
Affiliations
Centers for Disease Control and Prevention (US)
Corresponding author
Wunderli, Peter S.
Venue
Vaccine
Publisher
Elsevier BV
Published
1991-09
Volume
9
Issue
9
Pages
638-642
ISSN
0264-410X (ISSN-L)
OpenAlex
W2060386311
Cited by
43
References
32
Citations by year
2021: 2 · 2020: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 1
FWCI
0.57
Type
journal article
Language
en
Open access
closed
Locations
  • Vaccine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › Rabies epidemiology and control
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
Keywords
rabies vaccine, humoral immunity, neutralizing antibodies, intraperitoneal immunization, adoptive transfer, intracerebral challenge, pre-exposure prophylaxis, vaccine potency
MeSH terms
Animals, Antibodies, Viral, Female, Mice, Inbred BALB C, Mice, Inbred ICR, Rabies Vaccines, Vaccination, Immunotherapy, Adoptive, Mice

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