The protective role of humoral neutralizing antibody in the NIH potency test for rabies vaccines
Abstract
Intraperitoneal vaccination of mice with rabies vaccine results in both dosage-dependent rabies virus neutralizing antibody titres and protection from lethal intracerebral (i.c.) challenge with fixed strain CVS rabies virus. Pre-exposure adoptive intravenous transfer of naive or immune cells did not significantly protect naive Balb/c mice from lethal i.c. CVS challenge, but immune serum and anti-rabies glycoprotein monoclonal antibodies (individually and in combination) did confer significant protection when administered before or up to 24 h after lethal i.c. rabies virus challenge.
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A study in the NIH potency test for rabies vaccines reported that individual BALB/c mice with VN titers up to 7.8 IU/ml were not protected against i.c. challenge.
“a study analyzing the correlation between VN titer and protection against i.c. challenge for BALB/c mice in the NIH potency test for rabies vaccines reported that individual animals with titer up to 7.8 IU/ml were not protected [49]”
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(1992) · Current Opinion in Immunology · doi:10.1016/s0952-7915(06)80047-6
- Authors
- Wunderli, P. S., Shaddock, J. H., Scott Schmid, D., Miller, T. J., & Baer, G. M.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Wunderli, Peter S.
- ORCID
- Miller, Timothy J.
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 1991-09
- Volume
- 9
- Issue
- 9
- Pages
- 638-642
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2060386311
- Cited by
- 43
- References
- 32
- Citations by year
- 2021: 2 · 2020: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › Rabies epidemiology and control
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Keywords
- rabies vaccine, humoral immunity, neutralizing antibodies, intraperitoneal immunization, adoptive transfer, intracerebral challenge, pre-exposure prophylaxis, vaccine potency
- MeSH terms
- Animals, Antibodies, Viral, Female, Mice, Inbred BALB C, Mice, Inbred ICR, Rabies Vaccines, Vaccination, Immunotherapy, Adoptive, Mice
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