Renal afferent denervation prevents the progression of renal disease in the renal ablation model of chronic renal failure in the rat
Abstract
Rats with 5/6 nephrectomy develop hypertension and progressive deterioration in renal function. Several mechanisms may contribute to hypertension and to progressive renal disease in these rats. We have shown that increased activity of the sympathetic nervous system may contribute to hypertension in rats we chronic renal failure. However, the role of the sympathetic nervous system activity in the progression of renal disease has not been investigated. We have evaluated whether neurogenic factors contribute to the progression of renal disease in the renal ablation model of chronic renal failure in the rat. Sprague-Dawley rats underwent 5/6 nephrectomy and dorsal rhizotomy or sham rhizotomy (CRF). Age-matched normal rats were used as controls. Six weeks after surgery, rats with chronic renal failure and dorsal rhizotomy had lower blood pressure and serum creatinine than rats with sham rhizotomy. In addition, kidneys from rats with 5/6 nephrectomy and rhizotomy manifested less severe glomerulosclerosis than kidneys from rats without dorsal rhizotomy. These studies have demonstrated in rats with renal ablation. Although normalization of blood pressure may definitely play a role, the data raise the possibility that neurogenic impulses to the kidneys may contribute to the progression of renal disease.
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Renal parenchymal nociceptive sensory nerves respond to a renal injury signal by projecting to the hypothalamus to increase central sympathetic outflow.
“The first, of the renal parenchyma and bearing nociceptive receptors, respond to a renal injury signal by projecting to the hypothalamus to increase central sympathetic outflow95–99.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [99]
Cites
The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy
Lewis, E. J., Hunsicker, L. G., Bain, R. P., & Rohde, R. D. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311113292004 · Cited by 5,394 · see citing works
Dietary Protein Intake and the Progressive Nature of Kidney Disease:
Epstein, F. H., Brenner, B. M., Meyer, T. W., & Hostetter, T. H. (1982) · New England Journal of Medicine · doi:10.1056/nejm198209093071104 · Cited by 2,067 · see citing works
Sympathetic Overactivity in Patients with Chronic Renal Failure
Converse, R. L., Jacobsen, T. N., Toto, R. D., Jost, C. M. T., Cosentino, F., Fouad-Tarazi, F., & Victor, R. G. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212313272704 · Cited by 1,132 · see citing works
The Progression of Renal Disease
Epstein, F. H., Klahr, S., Schreiner, G. F., & Ichikawa, I. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806233182505 · Cited by 827 · see citing works
Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats
Raij, L. R., Azar, S., & Keane, W. F. (1984) · Kidney International · doi:10.1038/ki.1984.147 · Cited by 680 · see citing works
The functions of the renal nerves
Dibona, G. F. (1982) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/bfb0031333 · Cited by 421 · see citing works
Renal Afferent Denervation Prevents Hypertension in Rats With Chronic Renal Failure
Campese, V. M., & Kogosov, E. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.878 · Cited by 356 · see citing works
Self-citationFrontiers in neuroendocrinology
Fink, G. R. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90148-9 · Cited by 345 · see citing works
Brody, M. J., Mj, B., & Ak, J. (1980) · Cited by 317 · see citing works
Mechanisms of autonomic nervous system dysfunction in uremia
Campese, V. M., Romoff, M. S., Levitan, D., Lane, K. W., & Massry, S. G. (1981) · Kidney International · doi:10.1038/ki.1981.127 · Cited by 233 · see citing works
Self-citationRole of paraventricular and supraoptic nuclei in central cardiovascular regulation in the cat
Ciriello, J., & Calaresu, F. R. (1980) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1980.239.1.r137 · Cited by 186 · see citing works
Ward, D. G., & Gunn, C. G. (1976) · Brain Research · doi:10.1016/0006-8993(76)90236-5 · Cited by 152 · see citing works
Ciriello, J., & Calaresu, F. R. (1983) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(83)90110-8 · Cited by 138 · see citing works
Katholi, R. E., Whitlow, P. L., Hageman, G. R., & Woods, W. T. (1984) · PubMed · Cited by 136 · see citing works
Renal afferent nerves affect discharge rate of medullary and hypothalamic single units in the cat
Calaresu, F. R., & Ciriello, J. (1981) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(81)90072-2 · Cited by 131 · see citing works
Katholi, R. E., Whitlow, P. L., Hageman, G. R., & Woods, T. W. (1984) · Journal of Hypertension · doi:10.1097/00004872-198402040-00005 · Cited by 129 · see citing works
Hypertension in chronic renal failure. Treatment with hemodialysis and nephrectomy
Lazarus, J. M. (1974) · Archives of Internal Medicine · doi:10.1001/archinte.133.6.1059 · Cited by 114 · see citing works
Sympathetic Hyperactivity during Hypothalamic Stimulation in Spontaneously Hypertensive Rats
Takeda, K., & Buñag, R. D. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109171 · Cited by 112 · see citing works
Katholi, R. E., Winternitz, S., & Oparil, S. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110441 · Cited by 112 · see citing works
Henrich, W. L., Katz, F. H., Molinoff, P. B., & Schrier, R. W. (1977) · Kidney International · doi:10.1038/ki.1977.112 · Cited by 106 · see citing works
Faber, J. E., & Brody, M. J. (1985) · Circulation Research · doi:10.1161/01.res.57.5.676 · Cited by 90 · see citing works
A direct projection from the kidney to the brainstem
Wyss, J. M., & Donovan, M. K. (1984) · Brain Research · doi:10.1016/0006-8993(84)91154-5 · Cited by 79 · see citing works
Renal nerves and hypertension: an update.
Katholi, R. E. (1985) · PubMed · Cited by 76 · see citing works
Recordati, G., Moss, N., Genovesi, S., & Rogenes, P. R. (1981) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(81)90066-7 · Cited by 69 · see citing works
Plasma free, sulfo- and glucuro-conjugated catecholamines in uremic patients
Cuche, J. L., Prinseau, J., Selz, F., Ruget, G., & Baglin, A. (1986) · Kidney International · doi:10.1038/ki.1986.222 · Cited by 68 · see citing works
Effect of hypothalamic stimulation in spontaneously hypertensive and Wistar-Kyoto rats
Juskevich, J. C., Robinson, D. S., & Whitehorn, D. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90435-1 · Cited by 65 · see citing works
Altered norepinephrine turnover in the brown fat of rats with chronic renal failure.
Bigazzi, R., Kogosov, E., & Campese, V. M. (1994) · Journal of the American Society of Nephrology · doi:10.1681/asn.v4111896 · Cited by 65 · see citing works
Self-citationHypothalamic Vasopressor and Vesicopressor Pathways
Enoch, D. M. (1967) · Archives of Neurology · doi:10.1001/archneur.1967.00470210066008 · Cited by 61 · see citing works
Altered norepinephrine turnover in the brain of rats with chronic renal failure.
Bigazzi, R., Kogosov, E., & Campese, V. M. (1994) · Journal of the American Society of Nephrology · doi:10.1681/asn.v4111901 · Cited by 49 · see citing works
Self-citationSchalekamp, M. A. D. H., Schalekamp‐Kuyken, M. P. A., de Moor-Fruytier, M., et al. (1973) · Clinical Science · doi:10.1042/cs0450417 · Cited by 40 · see citing works
Sympathetic nervous system hyperactivity in maintenance hemodialysis patients.
Jl, I., Ms, I., Sterns, R. H., & Freeman, R. B. (1982) · PubMed · Cited by 36 · see citing works
Red blood cell catechol-o-methyl transferase, plasma catecholamines and renin in renal failure.
Atuk, N. O., Bailey, C. J., Turner, S., Mj, P., & Fb, W. (1976) · PubMed · Cited by 36 · see citing works
Lateral hypothalamus and sympathetic firing rate
Sakaguchi, T., Takahashi, M., & Bray, G. A. (1988) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1988.255.3.r507 · Cited by 34 · see citing works
Autonomic Nervous System Dysfunction in Uraemia
Campese, V. M. (1990) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/5.suppl_1.98 · Cited by 23 · see citing works
Self-citation
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Krum, H., Schlaich, M., Whitbourn, R., Sobotka, P. A., Sadowski, J., Bartus, K., Kapelak, B., Walton, A., Sievert, H., Thambar, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60566-3 · Cited by 2,108 · see citing works
The Sympathetic Nervous System Alterations in Human Hypertension
Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616 · see citing works
Sympathetic Activation in Chronic Renal Failure
Schlaich, M. P., Socratous, F., Hennebry, S., Eikelis, N., Lambert, E. A., Straznicky, N., Esler, M. D., & Lambert, G. W. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008040402 · Cited by 408 · see citing works
Early Sympathetic Activation in the Initial Clinical Stages of Chronic Renal Failure
Grassi, G., Quarti-Trevano, F., Seravalle, G., Arenare, F., Volpe, M., Furiani, S., Dell'Oro, R., & Mancia, G. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.164780 · Cited by 311 · see citing works
Neural Control of Renal Function
Johns, E. J., Kopp, U. C., & DiBona, G. F. (2011) · Comprehensive Physiology · doi:10.1002/cphy.c100043 · Cited by 278 · see citing works
Function of Renal Nerves in Kidney Physiology and Pathophysiology
Osborn, J. W., Tyshynsky, R., & Vulchanova, L. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031620-091656 · Cited by 171 · see citing works
Renal Nerves and Long‐Term Control of Arterial Pressure
Osborn, J. W., & Foss, J. D. (2017) · Comprehensive Physiology · doi:10.1002/cphy.c150047 · Cited by 93 · see citing works
Adamczak, M., Zeier, M., Dikow, R., & Ritz, E. (2002) · Kidney International · doi:10.1046/j.1523-1755.61.s80.28.x · Cited by 95 · see citing works
Singh, R. R., McArdle, Z. M., Iudica, M., Easton, L. K., Booth, L. C., May, C. N., Parkington, H. C., Lombardo, P., Head, G. A., Lambert, G., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12250 · Cited by 86 · see citing works
Improvement of albuminuria after renal denervation
Ott, C., Mahfoud, F., Schmid, A., Ditting, T., Veelken, R., Ewen, S., Ukena, C., Uder, M., Böhm, M., & Schmieder, R. E. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.03.017 · Cited by 75 · see citing works
Ott, C., Mahfoud, F., Mancia, G., Narkiewicz, K., Ruilope, L. M., Fahy, M., Schlaich, M. P., Böhm, M., & Schmieder, R. E. (2022) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfab154 · Cited by 62 · see citing works
Veiga, A. C., Milanez, M. I. O., Ferreira, G. R., Lopes, N. R., Santos, C. P., De Angelis, K., Garcia, M. L., Oyama, L. M., Gomes, G. N., Nogueira, F. N., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002304 · Cited by 49 · see citing works
- Authors
- Campese, V. M., Kogosov, E., & Koss, M.
- Affiliations
- University of Southern California (US)
- Venue
- American Journal of Kidney Diseases
- Publisher
- Elsevier BV
- Published
- 1995-11
- Volume
- 26
- Issue
- 5
- Pages
- 861-865
- ISSN
- 0272-6386 (ISSN-L)
- OpenAlex
- W2049453613
- Cited by
- 173
- References
- 34
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 11 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 12 · 2014: 18 · 2013: 13 · 2012: 8
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Kidney Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl035629-03, 5r01hl047881-04)
- National Heart, Lung, and Blood Institute (R01-HL-35629, 1 RO1-HL-47881)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- dorsal rhizotomy, chronic kidney disease, 5/6 nephrectomy, glomerulosclerosis, kidney disease progression, neurogenic factors, sympathetic nervous system, hypertension, serum creatinine, renal function
- MeSH terms
- Animals, Blood Pressure, Denervation, Kidney, Kidney Failure, Chronic, Male, Neurons, Afferent, Sympathetic Nervous System, Rats, Sprague-Dawley, Disease Progression, Rhizotomy, Rats
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