Cited by 173Chronic Kidney Disease and DiabetesBlood Pressure and Hypertension StudiesRenin-Angiotensin System Studies

Renal afferent denervation prevents the progression of renal disease in the renal ablation model of chronic renal failure in the rat

Campese, Vito M., Kogosov, Ella, Koss, Michael·1995·American Journal of Kidney Diseases

Abstract

Rats with 5/6 nephrectomy develop hypertension and progressive deterioration in renal function. Several mechanisms may contribute to hypertension and to progressive renal disease in these rats. We have shown that increased activity of the sympathetic nervous system may contribute to hypertension in rats we chronic renal failure. However, the role of the sympathetic nervous system activity in the progression of renal disease has not been investigated. We have evaluated whether neurogenic factors contribute to the progression of renal disease in the renal ablation model of chronic renal failure in the rat. Sprague-Dawley rats underwent 5/6 nephrectomy and dorsal rhizotomy or sham rhizotomy (CRF). Age-matched normal rats were used as controls. Six weeks after surgery, rats with chronic renal failure and dorsal rhizotomy had lower blood pressure and serum creatinine than rats with sham rhizotomy. In addition, kidneys from rats with 5/6 nephrectomy and rhizotomy manifested less severe glomerulosclerosis than kidneys from rats without dorsal rhizotomy. These studies have demonstrated in rats with renal ablation. Although normalization of blood pressure may definitely play a role, the data raise the possibility that neurogenic impulses to the kidneys may contribute to the progression of renal disease.

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Crossref · 10.1016/0272-6386(95)90456-5

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34 of 34 references verified0 citation errors · 0 not checkable

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  • Renal parenchymal nociceptive sensory nerves respond to a renal injury signal by projecting to the hypothalamus to increase central sympathetic outflow.

    “The first, of the renal parenchyma and bearing nociceptive receptors, respond to a renal injury signal by projecting to the hypothalamus to increase central sympathetic outflow95–99.”

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Authors
Campese, V. M., Kogosov, E., & Koss, M.
Affiliations
University of Southern California (US)
Venue
American Journal of Kidney Diseases
Publisher
Elsevier BV
Published
1995-11
Volume
26
Issue
5
Pages
861-865
ISSN
0272-6386 (ISSN-L)
OpenAlex
W2049453613
Cited by
173
References
34
Citations by year
2026: 2 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 11 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 12 · 2014: 18 · 2013: 13 · 2012: 8
FWCI
0.36
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Kidney Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl035629-03, 5r01hl047881-04)
  • National Heart, Lung, and Blood Institute (R01-HL-35629, 1 RO1-HL-47881)
Topics
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
dorsal rhizotomy, chronic kidney disease, 5/6 nephrectomy, glomerulosclerosis, kidney disease progression, neurogenic factors, sympathetic nervous system, hypertension, serum creatinine, renal function
MeSH terms
Animals, Blood Pressure, Denervation, Kidney, Kidney Failure, Chronic, Male, Neurons, Afferent, Sympathetic Nervous System, Rats, Sprague-Dawley, Disease Progression, Rhizotomy, Rats

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